## Loading required package: knitr

1 Prelim

1.1 Preprocessing

Prior to this script, MutationTimeR was run on 2x 2,778 VCF files for subs and indels each. This was done using the script VCF-annotate.R, attached at the end of this vignette.

Input files:

  • VCF files: Folder ../final/final_consensus_12oct_passonly
  • Allele-specific copy number: Folder ../final/consensus.20170119.somatic.cna.annotated
  • Subclone sizes and cell frequencies: ../final/structure_weme_released_consensus_merged.txt, ../final/wcc_consensus_values_9_12.tsv
  • Purity: ../final/consensus.20170218.purity.ploidy.txt

Output:

cat(paste0(system("for d in `find ../final/annotated_014 -maxdepth 1 -type d`
do echo $d; ls $d | head -6;
done", ignore.stderr=TRUE, intern=TRUE), collapse="\n"))
## ../final/annotated_014
## clusters
## cn
## graylist
## indel
## other
## snv_mnv
## ../final/annotated_014/snv_mnv
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20160830.somatic.snv_mnv.complete_annotation.vcf.bgz
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20160830.somatic.snv_mnv.complete_annotation.vcf.RData
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20160830.somatic.snv_mnv.complete_annotation.vcf.bgz
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20160830.somatic.snv_mnv.complete_annotation.vcf.RData
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20160830.somatic.snv_mnv.complete_annotation.vcf.bgz
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20160830.somatic.snv_mnv.complete_annotation.vcf.RData
## ../final/annotated_014/graylist
## clusters
## cn
## indel
## other
## snv_mnv
## ../final/annotated_014/other
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20160830.somatic.snv_mnv.complete_annotation.pdf
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20160830.somatic.snv_mnv.complete_annotation.pdf
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20160830.somatic.snv_mnv.complete_annotation.pdf
## 00493087-9d9d-40ca-86d5-936f1b951c93.consensus.20160830.somatic.snv_mnv.complete_annotation.pdf
## 00508f2b-36bf-44fc-b66b-97e1f3e40bfa.consensus.20160830.somatic.snv_mnv.complete_annotation.pdf
## 005794f1-5a87-45b5-9811-83ddf6924568.consensus.20160830.somatic.snv_mnv.complete_annotation.pdf
## ../final/annotated_014/indel
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20161006.somatic.indel.complete_annotation.vcf.bgz
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20161006.somatic.indel.complete_annotation.vcf.RData
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20161006.somatic.indel.complete_annotation.vcf.bgz
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20161006.somatic.indel.complete_annotation.vcf.RData
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20161006.somatic.indel.complete_annotation.vcf.bgz
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20161006.somatic.indel.complete_annotation.vcf.RData
## ../final/annotated_014/clusters
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20160830.somatic.snv_mnv.complete_annotation.clusters_purity.RData
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20160830.somatic.snv_mnv.complete_annotation.clusters_purity.RData
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20160830.somatic.snv_mnv.complete_annotation.clusters_purity.RData
## 00493087-9d9d-40ca-86d5-936f1b951c93.consensus.20160830.somatic.snv_mnv.complete_annotation.clusters_purity.RData
## 00508f2b-36bf-44fc-b66b-97e1f3e40bfa.consensus.20160830.somatic.snv_mnv.complete_annotation.clusters_purity.RData
## 005794f1-5a87-45b5-9811-83ddf6924568.consensus.20160830.somatic.snv_mnv.complete_annotation.clusters_purity.RData
## ../final/annotated_014/cn
## 0009b464-b376-4fbc-8a56-da538269a02f.consensus.20160830.somatic.snv_mnv.complete_annotation.bb_granges.RData
## 003819bc-c415-4e76-887c-931d60ed39e7.consensus.20160830.somatic.snv_mnv.complete_annotation.bb_granges.RData
## 0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20160830.somatic.snv_mnv.complete_annotation.bb_granges.RData
## 00493087-9d9d-40ca-86d5-936f1b951c93.consensus.20160830.somatic.snv_mnv.complete_annotation.bb_granges.RData
## 00508f2b-36bf-44fc-b66b-97e1f3e40bfa.consensus.20160830.somatic.snv_mnv.complete_annotation.bb_granges.RData
## 005794f1-5a87-45b5-9811-83ddf6924568.consensus.20160830.somatic.snv_mnv.complete_annotation.bb_granges.RData

Annotated VCF files and copy number segments with timing information will be loaded as shown below. This requires about 100G memory.

1.2 Libraries

Load convenience R functions (code shown at the end of this vignette).

source("PCAWG-functions.R")
## Loading required package: GenomeInfoDb
## Loading required package: BiocGenerics
## Loading required package: parallel
## 
## Attaching package: 'BiocGenerics'
## The following objects are masked from 'package:parallel':
## 
##     clusterApply, clusterApplyLB, clusterCall, clusterEvalQ, clusterExport, clusterMap, parApply,
##     parCapply, parLapply, parLapplyLB, parRapply, parSapply, parSapplyLB
## The following objects are masked from 'package:stats':
## 
##     IQR, mad, xtabs
## The following objects are masked from 'package:base':
## 
##     anyDuplicated, append, as.data.frame, cbind, colnames, do.call, duplicated, eval, evalq, Filter, Find,
##     get, grep, grepl, intersect, is.unsorted, lapply, lengths, Map, mapply, match, mget, order, paste,
##     pmax, pmax.int, pmin, pmin.int, Position, rank, rbind, Reduce, rownames, sapply, setdiff, sort, table,
##     tapply, union, unique, unsplit, which, which.max, which.min
## Loading required package: S4Vectors
## Loading required package: stats4
## 
## Attaching package: 'S4Vectors'
## The following objects are masked from 'package:base':
## 
##     colMeans, colSums, expand.grid, rowMeans, rowSums
## Loading required package: IRanges
## Loading required package: GenomicRanges
## Loading required package: Biostrings
## Loading required package: XVector
## Warning in is.na(x[[i]]): is.na() applied to non-(list or vector) of type 'environment'
## 'BiocParallel' did not register default BiocParallelParams:
##   invalid class "MulticoreParam" object: 1: 'cluster', '.clusterargs', '.uid', 'RNGseed' must be length 1
## invalid class "MulticoreParam" object: 2: '.clusterargs', '.controlled', 'logdir', 'resultdir' must be length 1
## Loading required package: SummarizedExperiment
## Loading required package: Biobase
## Welcome to Bioconductor
## 
##     Vignettes contain introductory material; view with 'browseVignettes()'. To cite Bioconductor, see
##     'citation("Biobase")', and for packages 'citation("pkgname")'.
## 
## Attaching package: 'VariantAnnotation'
## The following object is masked from 'package:base':
## 
##     tabulate
## Warning in eval(ei, envir): NAs introduced by coercion
## Loading required package: VGAM
## Loading required package: splines

Prepare spreadsheets for figure data

library(xlsx)
Figure1 <- createWorkbook()
Figure2 <- createWorkbook()
Figure4 <- createWorkbook()
Figure5 <- createWorkbook()
ExtendedDataFigure3 <- createWorkbook()
ExtendedDataFigure6 <- createWorkbook()
ExtendedDataFigure8 <- createWorkbook()
ExtendedDataFigure9 <- createWorkbook()
## Warning in eval(ei, envir): NAs introduced by coercion

2 Load processed data from MutationTimeR

2.1 Whitelist

First 2,703 whitelisted samples

2.1.1 SNV and MNV

Load annotated VCF files for SNVs and MNVs into a list with VariantAnnotation::VCF() objects:

p <- "../final/annotated_014/snv_mnv"
d <- dir(p, pattern="*.vcf.RData", full.names=TRUE)
finalSnv <- unlist(mclapply(split(d, seq_along(d) %/% 100), lapply, function(f) { # read in batches of 100
            e <- new.env()
            load(f, envir=e)
            e$vcf
        }, mc.preschedule=FALSE), recursive=FALSE)
names(finalSnv) <- sub(".conse.+","",dir(p, pattern="*.vcf.RData", full.names=FALSE))

2.1.2 Copy number profiles

Load copynumber profiles as a list of GRanges():

p <- "../final/annotated_014/cn"
finalBB <- list()
for( f in dir(p, pattern="*.bb_granges.RData", full.names=TRUE)){
    load(f)
    colnames(mcols(bb)) <- sub("star.1","time.star",colnames(mcols(bb)) ) # Fix naming problem
    finalBB[[f]] <- bb
}
names(finalBB) <- sub(".conse.+","",dir(p, pattern="*.bb_granges.RData", full.names=FALSE))

2.1.3 Indels

Load annotated VCF files for indels into a list with VariantAnnotation::VCF() objects:

p <- "../final/annotated_014/indel"
d <- dir(p, pattern="*.vcf.RData", full.names=TRUE)
finalIndel <- unlist(mclapply(split(d, seq_along(d) %/% 100), lapply, function(f) { # read in batches of 100
                    e <- new.env()
                    load(f, envir=e)
                    e$vcfIndel
                }, mc.preschedule=FALSE), recursive=FALSE)
names(finalIndel) <- sub(".conse.+","",dir(p, pattern="*.vcf.RData", full.names=FALSE))

2.1.4 Clusters and purity

These were input to MutationTimeR. Loaded as a list() (clusters) and data.frame (purity/ploidy).

finalClusters <- list()
finalPurity <- numeric()
p <- "../final/annotated_014/clusters"
for( f in dir(p, pattern="*.RData", full.names=TRUE)){
    load(f)
    finalClusters[[f]] <- clusters
    finalPurity[f] <- purity
}
names(finalClusters) <- names(finalPurity) <- sub(".conse.+","",dir(p, pattern="*.RData", full.names=FALSE))

2.2 Update drivers

finalDrivers is a VariantAnnotation::VRanges() object with driver point mutations (substitutions and indels), as provided by the PCAWG drivers working group. Here, we match these data with annotation from MutationTimeR. To this end, match samples and positions and copy annotation.

finalDriversAnnotated <- finalDrivers
d <- info(finalSnv[[3]])[seq_along(finalDriversAnnotated),19:32]
#d[,] <- NA
mcols(finalDriversAnnotated)[colnames(d)] <- d
for(i in seq_along(finalDriversAnnotated)){
    if(finalDriversAnnotated$mut_type[i] %in% c("snv","mnv")){
        v <- finalSnv[[as.character(finalDriversAnnotated$sample[i])]]
    }else{
        v <- finalIndel[[as.character(finalDriversAnnotated$sample[i])]]
    }
    j <- findOverlaps(finalDriversAnnotated[i], v, select='first')
    if(!is.na(j)){
        mcols(finalDriversAnnotated)[i,colnames(d)] <- info(v)[j, colnames(d)]
        refDepth(finalDriversAnnotated)[i] <- info(v)[j,"t_ref_count"]
        altDepth(finalDriversAnnotated)[i] <- info(v)[j,"t_alt_count"]
    }
    else
        mcols(finalDriversAnnotated)[i,colnames(d)] <- NA
}

2.3 Graylisted data

75 graylisted samples were processed separately using MutationTimeR. We load these just like the whitelisted samples and concatenate the output.

2.3.1 SNV and MNV

p <- "../final/annotated_014/graylist/snv_mnv"
finalSnvGray <- mclapply(dir(p, pattern="*.vcf.RData", full.names=TRUE), function(f) {
            e <- new.env()
            load(f, envir=e)
            e$vcf
        })
names(finalSnvGray) <- sub(".conse.+","",dir(p, pattern="*.vcf.RData", full.names=FALSE))
finalSnv[names(finalSnvGray)] <- finalSnvGray

2.3.2 Copy number profiles

p <- "../final/annotated_014/graylist/cn"
finalBBGray <- list()
for( f in dir(p, pattern="*.bb_granges.RData", full.names=TRUE)){
    load(f)
    colnames(mcols(bb)) <- sub("star.1","time.star",colnames(mcols(bb)) ) # Fix naming problem
    finalBBGray[[f]] <- bb
}
names(finalBBGray) <- sub(".conse.+","",dir(p, pattern="*.bb_granges.RData", full.names=FALSE))
finalBB[names(finalBBGray)] <- finalBBGray

2.3.3 Indel

p <- "../final/annotated_014/graylist/indel"
finalIndelGray <- mclapply(dir(p, pattern="*.vcf.RData", full.names=TRUE), function(f) {
            e <- new.env()
            load(f, envir=e)
            e$vcfIndel
        })
names(finalIndelGray) <- sub(".conse.+","",dir(p, pattern="*.vcf.RData", full.names=FALSE))
finalIndel[names(finalIndelGray)] <- finalIndelGray

2.3.4 Clusters and purity

finalClustersGray <- list()
finalPurityGray <- numeric()
p <- "../final/annotated_014/graylist/clusters"
for( f in dir(p, pattern="*.RData", full.names=TRUE)){
    load(f)
    finalClustersGray[[f]] <- clusters
    finalPurityGray[f] <- purity
}
names(finalClustersGray) <- names(finalPurityGray) <- sub(".conse.+","",dir(p, pattern="*.RData", full.names=FALSE))
finalClusters[names(finalClustersGray)] <- finalClustersGray
finalPurity <- c(finalPurity, finalPurityGray)

whiteList <- seq_along(finalSnv) %in% 1:2703
grayList <- !whiteList

2.4 Structural variants

Lastly, we load structural variant data. This is only available for a subset. We pad missing samples with NA

finalSv <- mclapply(dir("../final/pcawg_consensus_1.6.161116.somatic_svs", pattern='*.vcf.gz$', full.names=TRUE), function(x) {
            t <- try(readVcf(x))
            return(t)
        })
names(finalSv) <- sub("../final/pcawg_consensus_1.6.161116.somatic_svs/","", sub(".pcawg_consensus_1.6.161116.somatic.sv.vcf.gz","",dir("../final/pcawg_consensus_1.6.161116.somatic_svs", pattern='*.vcf.gz$', full.names=TRUE)))
finalSv <- finalSv[names(finalSnv)]

3 QC

Here we calculate basic QC for MutationTimeR output. info(vcf)$pMutCNTail contains the beta-binomial tail probability pbetabinom for every variant for its most likely clonal state. These should be roughly uniform, hence 1% outside [0.005,0.995] and about 5% outside [0.025,0.975]. Larger deviations indicate that either purity, copy number or clusters were wrong in a given sample.

q1 <- sapply(finalSnv, function(vcf) mean(abs(0.5- info(vcf)$pMutCNTail) > 0.495 , na.rm=TRUE))
q5 <- sapply(finalSnv, function(vcf) mean(abs(0.5- info(vcf)$pMutCNTail) > 0.475 , na.rm=TRUE))

Most samples agree, on average:

par(mfrow=c(1,1))
boxplot(1-q5 ~ donor2type[sample2donor[names(finalSnv)]], las=2, ylab="Fraction of data inside theoretical 95% CI")
abline(h=0.95, lty=3)

QQ-plots show few outliers per sample:

#pdf("QQplots.pdf", 4,4, pointsize=8)
par(mfrow=c(5,5))
for(i in seq_along(finalSnv)[1:25]){
    n <- nrow(finalSnv[[i]])
    qqnorm(qnorm(info(finalSnv[[i]])$pMutCNTail[sample(1:n, min(1e4,n))]), main=paste(substr(names(finalSnv)[i],1,8), "Q5 =", signif(q5[i],2), ", Q1 =", signif(q1[i],2)), xlim=c(-5,5), ylim=c(-5,5), pch=16)
    abline(0,1, col='red')
}

#dev.off()

4 Driver genotypes

Here we tabulate all driver point mutations and their clonal allele status.

4.1 MAP genotypes

These are the maximum a posteriori (MAP) assignments, used for the early/late/clonal/subclonal annotation output of MutationTimeR.

finalGenotypesSnv <- simplify2array(mclapply(finalSnv[whiteList], getGenotype, useNA="always"))
finalGenotypesIndel <- simplify2array(mclapply(finalIndel[whiteList], getGenotype, useNA="always"))
finalGenotypes <- aperm(abind::abind(subs=finalGenotypesSnv,indels=finalGenotypesIndel, along=5), c(1,5,2,3,4))
rm(finalGenotypesSnv,finalGenotypesIndel)

4.2 Probabilistic genotypes

Alternatively to the hard MAP assignments one can calculate the actual probailities per state and assess their overall distribution. This could avoid some biases of the MAP estimates, which are typically biased towards the more populous clonal states.

finalGenotypesSnvP <- simplify2array(mclapply(finalSnv[whiteList], probGenotype))
finalGenotypesIndelP <- simplify2array(mclapply(finalIndel[whiteList], probGenotype))
finalGenotypesP <- aperm(abind::abind(subs=finalGenotypesSnvP,indels=finalGenotypesIndelP, along=4), c(1,4,2,3))
rm(finalGenotypesSnvP,finalGenotypesIndelP)

4.3 Probabilistic genotypes - tail prob (QC)

As QC, we aggregate also the tail probabilities to find out whether there were annotation issues for some driver genes

finalGenotypesSnvQ <- simplify2array(mclapply(finalSnv[whiteList], probGenotypeTail))
finalGenotypesIndelQ <- simplify2array(mclapply(finalIndel[whiteList], probGenotypeTail))
finalGenotypesQ <- aperm(abind::abind(subs=finalGenotypesSnvQ,indels=finalGenotypesIndelQ, along=3), c(1,3,2))
rm(finalGenotypesSnvQ,finalGenotypesIndelQ)

5 Checkpoint

As the previous steps take rather long, introduce a checkpoint here and serialise the data, so it can be loaded later on.

save.image(file=dumpfile, compress=FALSE)
save(finalGenotypes, finalGenotypesP, finalGenotypesQ, file=paste0(Sys.Date(),"-FinalGenotypes.RData"))

6 Timing of point mutations

Here we assess the timing of point mutations, including driver gene mutations.

6.1 Duplicated donors

First, find samples with the same donor to avoid double dipping for some computations.

w <- names(finalSnv)
n <- names(which(table(sample2donor[w]) > 1)) # donors
s <- w[w %in% names(sample2donor[sample2donor %in% n])] # multisamples
d <- setdiff(sample2donor[w], sample2donor[levels(finalDrivers$sample)]) # donors w/o driver
u <- sample2donor[s[sample2donor[s] %in% intersect(d,n)]]
selectedSamples <- !w %in% setdiff(s[!s %in% finalDrivers$sample ], names(u)[!duplicated(u)])
uniqueSamples <- !duplicated(sample2donor[names(finalSnv)])

6.2 Overall distribution

6.2.1 Subs or indels

First assess the overall distributions of early/late/clonal/subclonal variants per sample, separately for subs and indels.

f <- function(x) unlist(sapply(seq_along(x), function(i) rep(i, x[i])))
d <- t(asum(finalGenotypesP[,"subs",,], 1))
o <- order(droplevels(donor2type[sample2donor[rownames(d)]]), -d[,1]/rowSums(d))
I <- t(apply(d/rowSums(d), 1, function(x) f(mg14:::roundProp(x * 100,p=100))))
d <- t(asum(finalGenotypesP[,"indels",,], 1))
J <- t(apply(d/rowSums(d), 1, function(x) if(!any(is.nan(x))) f(mg14:::roundProp(x * 100,p=100)) else rep(NA,100)))
s <- cumsum(table(droplevels(donor2type[sample2donor[rownames(d)]][o])))
col <- RColorBrewer::brewer.pal(9, "Set1")[c(3,4,2,1,9)] ## Colors for early-subclonal
par(fig=c(0,1,0,1),mar=c(1,4,1,1)+.1, mgp=c(2,.5,0), mfrow=c(3,1), bty="n", las=2, xpd=FALSE)
image(z=I[o,], x=1:nrow(I), useRaster=TRUE, col=col, xaxt="n", ylab="SNVs")
abline(v=s, col='white')
image(z=J[o,], x=1:nrow(I),useRaster=TRUE, col=col, xaxt="n", ylab="Indels")
abline(v=s, col='white')
par(bty="n", xpd=NA)
plot(NA,NA, xaxt="n", yaxt="n", xlab="", ylab="", xlim=c(0, nrow(J)), ylim=c(0,1), xaxs="i", yaxs='i')
d0 <- s - diff(c(0,s))/2
d1 <- mg14:::mindist(d0,30)
segments(d0, 1.12, d0, 1.2)
segments(d0, 1.12, d1, 1.08)
segments(d1, 1.08, d1, 1)
mg14::rotatedLabel(x0 = d1, names(s), y0=1)
legend("bottom", fill=col, legend=paste(dimnames(finalGenotypes)[[3]]), bty="n", horiz=TRUE, title="Mutation timing")

The proportions of subs and indels are remarkably similar.

6.2.2 Figure 2a

For the manuscript only plot subs, together with the color code for each tumour type.

f <- function(x) unlist(sapply(seq_along(x), function(i) rep(i, x[i])))
d <- t(sapply(names(finalSnv)[whiteList &  selectedSamples], function(n) table(info(finalSnv[[n]])$CLS, useNA='a') + table(info(finalIndel[[n]])$CLS, useNA='a')))
o <- order(droplevels(donor2type[sample2donor[rownames(d)]]), -d[,1]/rowSums(d))
I <- t(apply(d/rowSums(d), 1, function(x) f(mg14:::roundProp(x * 100,p=100))))
s <- cumsum(table(droplevels(donor2type[sample2donor[rownames(d)]][o])))

col <- RColorBrewer::brewer.pal(9, "Set1")[c(3,4,2,1,9)] ## Colors for early-subclonal
par(fig=c(0,1,0,1),mar=rep(0,4), bty="n", tcl=-0.25)
layout(matrix(1:5,nrow=5), height=c(1,4,1.2,0.8,4))
par(cex=1)
plot(NA,NA, xaxt="n", yaxt="n", xlab="", ylab="", xlim=c(0, nrow(I)), ylim=c(0,1), xaxs="i", yaxs='i')
legend("bottom", fill=col, legend=paste(dimnames(finalGenotypes)[[3]]), bty="n", horiz=TRUE, title="Mutation timing", cex=1)
par(mar=c(0,4,0,0)+.1, mgp=c(2,.5,0), bty="n", las=2, xpd=FALSE, cex=1)
image(z=I[o,], x=1:nrow(I), useRaster=TRUE, col=col, xaxt="n", ylab="Point mutations")
abline(v=s, col='white')
u <- par("usr")
par(bty="o")
barplot(t(t(table(droplevels(donor2type[sample2donor[rownames(d)]][o])))), horiz=TRUE, col=tissueColors[names(s)], border=NA, xlim=u[1:2], yaxs='i', xaxt="n")
par(bty="n", xpd=NA)
plot(NA,NA, xaxt="n", yaxt="n", xlab="", ylab="", xlim=c(0, nrow(I)), ylim=c(0,1), xaxs="i", yaxs='i')
d0 <- s - diff(c(0,s))/2
d1 <- mg14:::mindist(d0,60)
segments(d0, 0.66, d0, 1)
segments(d0, 0.66, d1, 0.33)
segments(d1, 0.33, d1, 0)
mg14::rotatedLabel(x0 = d1, names(s), y0=0)

Also dump the xlsx output.

Figure2a <- createSheet(Figure2, "Figure2a")
addDataFrame(data.frame(d,cancer=droplevels(donor2type[sample2donor[rownames(d)]]))[o,c(6,1:5)], Figure2a)

#t <- 12/8
#dev.copy2pdf(file="finalMutationPropAll.pdf", width=9*t, height=1.8*t, pointsize=8*t)

6.2.3 Barplot drivers

Not turn to driver point mutations. Extract from the large arrays calculated above.

p <- asum(finalGenotypesP[,,,selectedSamples[whiteList]], c(2,4))
g <- asum(finalGenotypes[,,,,selectedSamples[whiteList]], c(2,4:5))
g <- g[order(rowSums(g), decreasing=TRUE),]
colnames(g) <- paste(colnames(g))
rownames(g) <- paste(rownames(g)) 
rownames(p) <- paste(rownames(p))
p <- p[rownames(g),]
w <- rowSums(g) > 0
w[1] <- FALSE

Collapse into unique genes

l <- sapply(strsplit(rownames(p),"::"), function(x) paste(x[2:3], collapse=":"))
pu <- t(sapply(unique(l), function(u) asum(p[l==u,,drop=FALSE], 1)))
gu <- t(sapply(unique(l), function(u) asum(g[l==u,,drop=FALSE], 1)))
gu <- gu[order(rowSums(gu), decreasing=TRUE),]
pu <- pu[rownames(gu),]
wu <- rowSums(gu) > 0
wu[1] <- FALSE

Now plot as a barplot. All drivers, with the top 50 as an inset.

par(fig=c(0,1,0,1),mar=c(1,4,1,1)+.1, mgp=c(3,.5,0))
barplot(t(gu[wu,]), col=col, las=2, legend=TRUE, args.legend=list("topright", bty='n'), ylab="Number of cases", names.arg=rep("",sum(wu)), border=NA)
#mg14::rotatedLabel(x=.Last.value,labels=rownames(g)[62:201], cex=.25)

u <- par("usr")
v <- c(
        grconvertX(u[1:2], "user", "ndc"),
        grconvertY(u[3:4], "user", "ndc")
)
v <- c( (v[1]+v[2])/3.33, v[2], (v[3]+v[4])/3, v[4] )
par( fig=v, new=TRUE, mar=c(0,0,0,0) )
b <- barplot(t(gu[2:51,]), col=col, las=2,  names.arg=rep("",50))
mg14::rotatedLabel(x=b,labels=rownames(gu)[2:51], cex=.5)

#dev.copy2pdf(file="finalDrivers.pdf", width=9, height=5, pointsize=8)

Also generate xlsx output

Figure2a2 <- createSheet(Figure2, "Figure2a2")
addDataFrame(gu[wu,], Figure2a2)

gt <- asum(finalGenotypes[,,,,selectedSamples[whiteList]], c(2:4))
t <- droplevels(donor2type[sample2donor[colnames(gt)]])
rownames(gt) <- paste(rownames(gt))
gt <- gt[rownames(g),] %*% model.matrix(~t-1)
colnames(gt) <- levels(t)
gtu <- t(sapply(unique(l), function(u) asum(gt[l==u,,drop=FALSE], 1)))
gtu <- gtu[rownames(gu),]

Figure2a3 <- createSheet(Figure2, "Figure2a3")
addDataFrame(gtu[wu,], Figure2a3)

Proportions may be more revealing than absolute numbers:

par(fig=c(0,1,0,1),mar=c(3,4,1,1)+.1, mgp=c(3,.5,0))
w <- rowSums(pu) > 0
n <- 50
b <- barplot(t(pu /rowSums(pu))[,w], width=c(rep(2,n+1), rep(0.2,sum(w)-n-1)), space=c(0,2,rep(0.1,n), rep(0,sum(w)-n-2)), col=col, border=NA, ylab="Fraction of mutations", names.arg=rep("",sum(w)))
mg14::rotatedLabel(x=b[1:(n+1)],labels=c("Genome-wide", rownames(pu)[2:(n+1)]), cex=.5)

#s <- 12/8
#dev.copy2pdf(file="finalDriversProp.pdf", width=9*s, height=3*s, pointsize=8*s)

6.2.4 Cumulative distribution of driver mutations

Sort driver mutations by prevalence in each timing class. Clearly the MAP estimate is biased downwards for driver genes not observed in a final cohort size. Hence to this without and with a pseudocount of one (which will overestimate). Report the average of the two as the point estimate.

tt <- abind::abind(pu[-1,], pu[-1,] + 0.5, along=3)

par(mar=c(3,3,1,1), mgp=c(2,.5,0), bty="L")
r <- array(apply(tt/rep(colSums(tt), each=nrow(tt)), 3, function(x) apply(x, 2, function(y) cumsum(sort(y, decreasing=TRUE)))), dim=dim(tt))
plot(cumsum(sort(r[,1,1], decreasing=TRUE)), col=NA, type='s', xlab="Number of different driver genes", ylab="Fraction of driver mutations", log='', ylim=c(0,1), xlim=c(0,664), xaxs='i', yaxs='i')
for(j in 1:4) {
    polygon(c(1:nrow(r), nrow(r):1), c(r[,j,1], rev(r[,j,2])), col=paste0(col[j],"33"), border=NA)
    lines((r[,j,1]+r[,j,2])/2, col=col[j], lwd=2)
    points(y=0,x=which.min((r[,j,1]+r[,j,2])/2 < 0.5), col=col[j], pch="|")
}
legend("bottomright", col=col[1:4], lty=1, paste0(c("clonal [early]", "clonal [late]", "clonal [other]", "subclonal"), ", n=", round(colSums(p[-1,]))[-5]), bty="n")
abline(h=0.5, lty=3)

#dev.copy2pdf(file="finalGenesCumulative.pdf", width=4,height=4)

6.2.5 Figure 2d

Now plot the value where the number of unique genes contributes 50% of all driver mutations.

par(mar=c(4,3,2.5,1), mgp=c(2,.5,0), bty="L")
d50 <- apply((r[,,1]+r[,,2])/2 < 0.5, 2, which.min)[c(1,3,2,4)]
b <- barplot(d50,las=2, col=col[c(1,3,2,4)], border=NA, ylab="Genes contributing 50% of driver mutations")
lo <- apply(r[,,1] < 0.5, 2, which.min)[c(1,3,2,4)]
hi <- apply(r[,,2] < 0.5, 2, which.min)[c(1,3,2,4)]
segments(b,lo,b,hi)
mg14::rotatedLabel(x=b,labels=c("clonal [early]", "clonal [late]", "clonal [other]", "subclonal")[c(1,3,2,4)])

#dev.copy2pdf(file="finalGenes50.pdf", width=3,height=4)

xlxs output

Figure2d <- createSheet(Figure2, "Figure2d")
addDataFrame(data.frame(d50, lo, hi, row.names=c("clonal [early]", "clonal [late]", "clonal [other]", "subclonal")[c(1,3,2,4)]), Figure2d)

7 Whole-genome duplications

Now turn to the timing of copy number alterations. First assess the whole genome duplications (WGD).

7.1 Prelim

Final ploidy, weighted if subclonal CN

finalPloidy <- sapply(finalBB, averagePloidy)
names(finalPloidy) <- names(finalBB)

Final homozygousity, weighted if subclonal CN

finalHom <- sapply(finalBB, averageHom)
names(finalHom) <- names(finalBB)

7.2 WGD classification

WGD is primarily classified by the copy number data. Additionally we assess the concordance of timing.

7.2.1 Based on ploidy and homozygousity

Using the quantities above, we classify WGD samples. This is the official WG output.

isWgd <- .classWgd(finalPloidy, finalHom)
table(isWgd)
## isWgd
## FALSE  TRUE 
##  1960   818
plot(finalHom, finalPloidy, col=.classWgd( finalPloidy, finalHom)+1, xlim=c(0,1))

7.2.2 Based on timing

Further it’s worthwile assessing whether the different copy number segments show the same timing, which would be expected for WGD. We do this for both WGD and near diploid (ND) samples.

fracGenomeWgdComp <- t(sapply(finalBB, function(bb) {
                    fgw <- try(fractionGenomeWgdCompatible(bb)); 
                    if(class(fgw)!='try-error') fgw
                    else rep(NA,10)}))
rownames(fracGenomeWgdComp) <- names(finalBB)

The temporal concordance defines out rating. Some samples are uninformative (especially ND) either due to too little point mutations (large timing CIs), or too few gained segments.

wgdStar <- factor(rep(1,nrow(fracGenomeWgdComp)), levels=0:3, labels=c("unlikely","uninformative","likely","very likely"))
wgdStar[fracGenomeWgdComp[,"avg.ci"]<=0.75 & fracGenomeWgdComp[,"nt.total"]/chrOffset["MT"] >= 0.33 ] <- "likely"
wgdStar[fracGenomeWgdComp[,"nt.wgd"]/fracGenomeWgdComp[,"nt.total"] < 0.66] <- "unlikely"
wgdStar[wgdStar=="likely" & fracGenomeWgdComp[,"nt.wgd"]/fracGenomeWgdComp[,"nt.total"] > 0.8 & fracGenomeWgdComp[,"sd.wgd"] < 0.1 &  fracGenomeWgdComp[,"nt.total"]/chrOffset["MT"] > 0.5] <- "very likely"
names(wgdStar) <-  names(finalBB)
prop.table(table(wgdStar[!isWgd]))
## 
##      unlikely uninformative        likely   very likely 
##   0.203061224   0.775510204   0.019387755   0.002040816
wgdPoss <- !isWgd & 2.5 - 1.5 * finalHom <= finalPloidy

wgdStat <- factor(wgdPoss + 2*isWgd - wgdPoss*isWgd, labels=c("absent","possible","present"))
table(wgdStat, wgdStar)
##           wgdStar
## wgdStat    unlikely uninformative likely very likely
##   absent        384          1492      9           0
##   possible       14            28     29           4
##   present        68             1    573         176

Overall, WGD samples display a high level of temporal concordance, as hoped.

8 Temporal distribution of chromosomal gains

In this section we assess the temporal distribution of large-scale copy number gains.

8.1 Functions

This one aggregates individual segments by chromosome

aggregatePerChromosome <- function(bb, isWgd=FALSE){
    .aggregateSegments <- function(m){
        #m <- mcols(bb)
        t <- weighted.mean(m$time, m$n.snv_mnv, na.rm=TRUE)
        n <- sum(m$n.snv_mnv[!is.na(m$time)], na.rm=TRUE)
        sd <- sd(m$time, na.rm=TRUE)
        ci <- weighted.mean(m$time.up-m$time.lo, m$n.snv_mnv, na.rm=TRUE)
        w <- sum(m$width[!is.na(m$time)], na.rm=TRUE)
        c(time=t, n=n, sd=sd, ci=ci,w=w)
    }
#   if(!isWgd){
    s <- split(as.data.frame(bb)[,c("time","time.up","time.lo","n.snv_mnv","width")], seqnames(bb))
    r <- t(sapply(s, .aggregateSegments))
    r <- r[c(1:22,"X"),]
#   }else{
    w <- .aggregateSegments(as.data.frame(bb))
    r <- rbind(r,WGD=w)
#   }
    return(r)
}

8.2 Aggregated timing per chromosome

This provides an average timing estimate per chromosome, per sample.

allChrAgg <- simplify2array(mclapply(finalBB, aggregatePerChromosome, mc.cores=2))

t <- allChrAgg[1:23,"time",!isWgd]
t[allChrAgg[1:23,"w",!isWgd] < diff(chrOffset)[1:23]*.33] <- NA

s <- split(as.data.frame(t(t)), droplevels(donor2type[sample2donor[names(finalSnv)]])[!isWgd])
n <- 10


at <- function(x, n){
    if(sum(!is.na(x))<3) return(rep(sum(!is.na(x))/n,n))
    bw=if(sum(!is.na(x))< 6) 0.5 else "nrd0"
    d <- density(x, n=n, from=1/n/2, to=1-1/n/2, bw=bw, na.rm=TRUE)
    d$y/sum(d$y)*d$n
}

allChrCancerHist <- sapply(s, apply, 2, at, n=n, simplify="array")
u <- split(data.frame(WGD=allChrAgg["WGD","time",isWgd]), droplevels(donor2type[sample2donor[names(finalSnv)]])[isWgd])
wgdCancerHist <- sapply(u, function(x) if(nrow(x)>0){at(x$WGD,n=n)}else{rep(0,n)}, simplify="array")
allChrCancerHist <- abind::abind(allChrCancerHist, All=sapply(sapply(s, as.matrix), at, n=n, simplify="array")/23*5, WGD=wgdCancerHist, along=2)

8.2.1 Per tumour type

Plot the timing histograms (deciles) per chromosome per cancer type, similar to Figure 1c in the final publication.

prgn <- RColorBrewer::brewer.pal(11,"PRGn")
set1 <- RColorBrewer::brewer.pal(9,"Set1")
col <- colorRampPalette(set1[c(4,9,3)])(n)

p <- 0
v <- table(droplevels(donor2type[sample2donor[names(finalSnv)]]))
h <- (allChrCancerHist + p)  / rep(v + p, each=prod(dim(allChrCancerHist)[1:2]))
h <- aperm(h, c(2,3,1))

a <- colMeans(h[c("All","WGD"),,] * c(23/5,1)) %*% 1:n / asum(h* c(23/5,1), c(1,3))
o <- order(-a)
h <- h[,o,]
w <- v[o]>=15 & apply(h, 2, max) > 0.05*8/n
h <- h[,w,]

m <- 0.02
layout(matrix(1:prod(dim(h)[1:2]+1), ncol=dim(h)[1]+1, byrow=TRUE), height=c(rev(apply(h, 2, max))+m, 0.15), width=c(5, rep(1,dim(h)[1])))
par(mar=c(0.05,0.1,0,0.1), xpd=NA)
for(j in dim(h)[2]:0+1) for(i in 0:dim(h)[1]+1) {
        #if(all(h[i,j,]==0)) 
        if(i==1 & j !=1) {plot(NA,NA,xlab="",ylab="", xaxt="n",yaxt="n",xlim=c(0,1),ylim=c(0,1), bty="n")
            text(1,0,dimnames(h)[[2]][j-1],pos=2)
            next
        }
        if(j ==1 ){
            plot(NA,NA,xlab="",ylab="", xaxt="n",yaxt="n",xlim=c(0,1),ylim=c(0,1), bty="n")
            if(i==1) next
            text(0.5,1,dimnames(h)[[1]][i-1],pos=1)
            next
        }
        r <- c(0,max(h[,j-1,]+m))
        par(bty=if(i==2)"L" else "n")
        barplot(h[i-1,j-1,], ylim=r, width=1/n,space=0, col=rev(col), xaxt="n", yaxt="n", xlab="",ylab="", border=NA,xpd=TRUE, yaxs="i", xaxs="i", xlim=c(-0.5/n,1+0.5/n))
        axis(side=1, at=c(-0.5/n,1+0.5/n), labels=c("",""), tcl=-.1)
        if(i>1)
            abline(v=0, col='lightgrey', lty=3)
        if(i==2){
            abline(h=0.05*8/n, col='lightgrey', lty=1)
            axis(side=2, at=c(0,0.05*8/n), labels=c("",""), tcl=-.1)
        }
    }

#dev.copy2pdf(file="histTiming.pdf",width=6, height=6, pointsize=8)


vv <- v[dimnames(h)[[2]]]
vv <- vv/sum(vv)

hh <- matrix(matrix(aperm(h, c(1,3,2)), ncol=length(vv)) %*% vv, nrow=nrow(h))
rownames(hh) <- rownames(h)

8.2.2 Pan-Can histograms

It can also be instructive to study the timing histograms pan-cancer:

par(mar=c(3,3,1,1), mgp=c(2,.5,0), tcl=-0.5, bty="L", xpd=NA)
barplot(hh["WGD",], space=0, col=rev(col), xlab="Time [mutations]", ylab="Relative frequency", width=0.1, ylim=c(0,.065), yaxs='r', border=NA)
axis(side=1)

barplot(hh["All",], space=0, col=rev(col), xlab="Time [mutations]", ylab="Relative frequency", width=0.1, ylim=c(0,.065), yaxs='r', border=NA)
axis(side=1)

#dev.copy2pdf(file="histTimingPanCan.pdf",width=2, height=2, pointsize=8)

8.3 Glioblastoma

GBMs display very early timing on chromosomes 7, 20 and 21. Plot a few.

w <- which(fracGenomeWgdComp[,"time.wgd"]<0.1 & fracGenomeWgdComp[,"nt.total"]/chrOffset["MT"] > 0.1 &  !isWgd & donor2type[sample2donor[names(finalBB)]]=="CNS-GBM")
plotSample(w[1])

plotSample(w[2])

plotSample(w[3])

8.3.1 Extended Data Figure 3a

Explore the early timing of chromosome 7 a bit more deeply. Find all GBMs with +7

w <- which(donor2type[sample2donor[names(finalSnv)]]=="CNS-GBM") 
w <- w[sapply(finalBB[w], function(bb) sum(width(bb)[as.logical(seqnames(bb)==7) & bb$total_cn >= 3], na.rm=TRUE)/width(refLengths[7])>0.8)]

Plot the first 10

for(ww in w[1:10]){ 
    finalSnv[[ww]] -> v
    v <- v[seqnames(v)==7]
    v <- v[which(info(v)$MajCN <= 4 & info(v)$MajCN > 1)]
    n <- sum(info(v)$MutCN==info(v)$MajCN, na.rm=TRUE)
    plotSample(ww, title=paste0(sample2icgc[names(finalSnv)[ww]], ", n=", n,"/",nrow(v), " SNVs pre +7"))
}

Tabulate the number of point mutations preceding +7

t <- t(sapply(w, function(ww){
                    finalSnv[[ww]] -> v
                    v <- v[seqnames(v)==7]
                    v <- v[which(info(v)$MajCN <= 4 & info(v)$MajCN > 1)]
                    n <- sum(info(v)$MutCN==info(v)$MajCN, na.rm=TRUE)
                    c(pre_7=n, total=nrow(v))
                }))
rownames(t) <- names(finalSnv)[w]

Less than 3 early

table(t[,1]<=3)
## 
## FALSE  TRUE 
##     7    27

8.3.2 Extended Data Figure 3b

Plot the distributions of early and toal point mutations on chr7 across all GBM samples with +7:

.par()
par(bty="n")
beeswarm::beeswarm(as.numeric(pmax(t,0.5)) ~ factor(rep(c("pre +7","total"), each=nrow(t))), method='hex', pch=19, xlab="", ylab="Number of SNVs", cex=0.5, log=TRUE, yaxt='n', col=set1[c(3,9)])
axis(side=2, at=c(1,10,100,1000))
axis(side=2, at=0.5, label=0)
for( i in 0:2) axis(side=2, at=c(2,3,4,5,6,7,8,9)*10^i, labels=rep("",8), tcl=-0.1)

#dev.off()

Generate xlsx output:

ExtendedDataFigure3b <- createSheet(ExtendedDataFigure3, "ExtendedDataFigure3b")
addDataFrame(t, ExtendedDataFigure3b)

8.4 Medulloblastoma

Medulloblastoma showed very frequent and early i17q. Gather them all:

w <- which(donor2type[sample2donor[names(finalSnv)]]=="CNS-Medullo") 
w <- w[sapply(finalBB[w], function(bb) sum(width(bb)[as.logical(seqnames(bb)==17) & bb$total_cn >= 3], na.rm=TRUE)/width(refLengths[17])>0.5)]

8.4.1 Extended Data Figure 3c

Plot first 10 samples

#pdf("Medullo_i17q.pdf",3.2,3.2, pointsize=8)
for(ww in w[1:10]){
    finalSnv[[ww]] -> v
    v <- v[seqnames(v)==17]
    v <- v[which(info(v)$MajCN <= 4 & info(v)$MajCN > 1)]
    n <- sum(info(v)$MutCN==info(v)$MajCN, na.rm=TRUE)
    plotSample(ww, title=paste0(sample2icgc[names(finalSnv)[ww]], ", n=", n,"/",nrow(v), " SNVs pre i17q"))
}

Tabulate early and late substitutions.

t <- t(sapply(w, function(ww){
                    finalSnv[[ww]] -> v
                    v <- v[seqnames(v)==17]
                    v <- v[which(info(v)$MajCN <= 4 & info(v)$MajCN > 1)]
                    n <- sum(info(v)$MutCN==info(v)$MajCN, na.rm=TRUE)
                    c(pre_i17q=n, total=nrow(v))
                }))
rownames(t) <- names(finalSnv)[w]

Less than 1 early

table(t[,1]<=1)
## 
## FALSE  TRUE 
##    21    74

8.4.2 Extended Data Figure 3d

Plot distribution across samples

.par()
par(bty="n")
beeswarm::beeswarm(as.numeric(pmax(t,0.5) + runif(length(t))*0.25 -0.1) ~ factor(rep(c("pre i17q","total"), each=nrow(t))), method='hex', pch=19, xlab="", ylab="Number of SNVs", cex=0.5, log=TRUE, yaxt='n', col=set1[c(3,9)], corral="gutter", corralWidth=1.25)
axis(side=2, at=c(1,10,100,1000))
axis(side=2, at=0.5, label=0)
for( i in 0:2) axis(side=2, at=c(2,3,4,5,6,7,8,9)*10^i, labels=rep("",8), tcl=-0.1)

Dump xlsx output

ExtendedDataFigure3d <- createSheet(ExtendedDataFigure3, "ExtendedDataFigure3d")
addDataFrame(t, ExtendedDataFigure3d)
saveWorkbook(ExtendedDataFigure3,'ExtendedDataFigure3.xlsx')

9 Synchronous gains

One thing observed in the temporal classification of WGD samples was that a surprisingly high fraction of near-diploid samples also display very concordant timings. Here we provide a basic assessment of the phenomenon. The final results were further refined, more accurately considering the exact copy numeber configurations involved.

9.1 Synchronous/asynchronous classification

Note: Final figures have slightly deviated from this earlier version due to more elaborate handling of segments.

d <- fracGenomeWgdComp
i <- d[,"avg.ci"]<=0.5 & d[,"chr.all"] > 2 #&  fracGenomeWgdComp[,"nt.total"]/chrOffset["MT"] >= 0.1
timingClass <- paste(ifelse(isWgd,"WGD","ND"), ifelse(!i, "uninformative",""))
timingClass[i] <- paste0(timingClass[i], ifelse(d[i,"nt.wgd"]/d[i,"nt.total"] > 0.75,"sync","async"))
#timingClass[i] <- paste0(timingClass[i], cut(fracGenomeWgdComp[i,"nt.wgd"]/fracGenomeWgdComp[i,"nt.total"], c(0,0.5,0.8,1), include.lowest=TRUE))
timingClass <- factor(timingClass)

9.1.1 Figure 1f

First the pie chart with the timing classification

#pdf("TimingClass.pdf", 4,4)
colTime <- c("#A0C758","#6B8934","#BEC6AD","#CEB299","#CC6415","#EF7B00")
names(colTime) <- levels(timingClass)[c(4,5,6,3,2,1)]
c <- c(RColorBrewer::brewer.pal(9, "Pastel1"),"#DDDDDD")
t <- table(timingClass)[names(colTime)]
pie(t, init.angle=90, labels=paste0(names(t), ",\nn=", t), col=colTime)
#t <- table(isWgd)
par(new=TRUE)
symbols(x=0,y=0,circles=0.4, inches=FALSE, add=TRUE, bg="white")

#pie(t, labels=c("",""), col=NA, lwd=5, lty=1, init.angle=90)
#dev.off()

xlsx output

Figure1f <- createSheet(Figure1, "Figure1f")
addDataFrame(t, Figure1f)

colnames(d) <- c("ntCoamp","ntAmp","timeCoamp","segCoamp","segAmp","chrCoamp","chrAmp", "sdTimeCoamp","avgCiSeg","sdAllSeg")
timingInfo <- data.frame(avgPloidy=finalPloidy, avgHom=finalHom, isWgd=isWgd, d, informative=i, timingClass=timingClass)
#tab <- rbind(tab, data.frame(WGD_call=otherStat, WGD_timing=NA, ploidy=otherPloidy, hom=otherHom, nt.wgd=NA, nt.total=NA, time.wgd=NA, sd.wgd=NA,avg.ci=NA, sd.all=NA))
write.table(file=paste0(Sys.Date(),"-Timing-info.txt"), timingInfo, quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

9.2 Examples

Show 9 prototypical examples for the different timing classes.

9.2.1 Figure 1e

w <- which(wgdStar=="likely" & !isWgd) # Garden variety near-diploid with concordant timing
plotSample(w[1]) 

plotSample(w[2])

plotSample(w[3])

w <- which(wgdStar=="very likely" & isWgd) # Now a-star WGD with highly concordant timing.
plotSample(w[1])

plotSample(w[2])

plotSample(w[9])

w <- which(wgdStar=="unlikely" & !isWgd & fracGenomeWgdComp[,"nt.total"]/chrOffset["MT"] > 0.25 & fracGenomeWgdComp[,"avg.ci"] < 0.5) # Near diploid with highly discordant timing
plotSample(w[1])

plotSample(w[2])

plotSample(w[3])

9.3 Relationship with mutation rates

As a sanity check for the molecular timing estimates, calculate number of substitutions and timing per tumour type. There shouldn’t be a trend.

n <- nSub <- sapply(finalSnv, nrow)
n[timingInfo$timeCoamp==0] <- NA
q <- unlist(sapply(split(n, donor2type[sample2donor[names(finalSnv)]]), function(x) as.numeric(cut(x, {if(sum(!is.na(x))>1) quantile(x, seq(0,1,0.1), na.rm=TRUE) else 1:10}, include.lowest=TRUE))))
m <- match(names(finalSnv),unlist(split(names(finalSnv), donor2type[sample2donor[names(finalSnv)]])))
t <- timingInfo$timeCoamp
table(decSub=q[m], time=cut(t, seq(0,1,0.1)))
##       time
## decSub (0,0.1] (0.1,0.2] (0.2,0.3] (0.3,0.4] (0.4,0.5] (0.5,0.6] (0.6,0.7] (0.7,0.8] (0.8,0.9] (0.9,1]
##     1       19        14        12        23        27        18        25        28        40      13
##     2       13        11        12        18        18        18        21        32        29      28
##     3       15        11        16        13        15        18        31        34        24      21
##     4       16        13        13        10        22        16        12        28        37      29
##     5        8        13        14        14        15        18        18        36        35      34
##     6       15         8        20        11        12        18        19        21        38      34
##     7        8        13        14        12        16        15        26        26        37      26
##     8       13         5        16        15        16        19        23        29        37      28
##     9       20        18        10        15        20        14        16        31        25      28
##     10      27        17        14        17        13        23        17        25        24      40

Also calculate deciles of timing per tumour type; this is an even stronger indication of independence, as hoped.

t[t==0] <- NA
r <- unlist(sapply(split(t, donor2type[sample2donor[names(finalSnv)]]), function(x) as.numeric(cut(x, {if(sum(!is.na(x))>1 & length(unique(x)) > 2) quantile(jitter(x), seq(0,1,0.1), na.rm=TRUE) else 1:10}, include.lowest=TRUE))))
table(decSub=q[m], decTime=r[m])
##       decTime
## decSub  1  2  3  4  5  6  7  8  9 10
##     1  24 25 30 20 23 17 13 24 16 20
##     2  16 22 18 17 21 21 24 19 18 24
##     3  22 18 16 26 14 21 27 19 19 13
##     4  19 14 22 18 21 23 17 21 19 21
##     5  10 26 16 22 19 12 17 27 30 18
##     6  19 15 18 15 19 19 26 21 22 17
##     7   8 20 23 25 17 25 19 14 21 18
##     8  13 24 21 18 18 21 24 18 23 19
##     9  26 21 17 23 18 15 20 21 15 19
##     10 39 18 14 21 26 14 20 16 19 22

Plot the number of mutations per sample vs the average duplication time.

#pdf("timeNsub.pdf", 3, 2.5, pointsize=8)
par(mar=c(3,4,1,1), bty="n", mgp=c(2,.5,0), las=1, tcl=-.25) 
d <- as.character(donor2type[sample2donor[names(finalSnv)]])
lineCol <- tissueColors
lineCol[grep("Lung", names(lineCol))] <- "black"
plot(t, nSub, log='y', bg=tissueColors[d], pch=21, xlab="Typical amplification time", ylab="", cex=.66, lwd=.5, yaxt="n", ylim=c(100,3e6))
mtext(side=2, "Number of SNVs", line=3, las=3)
u <- round(par("usr")[3:4])
a <- axisTicks(par("usr")[3:4], log=TRUE)
axis(side=2, at=a, labels=prettyNum(a))
b <- sapply(a[-length(a)], function(x) (1:10)*x)
axis(side=2, at=b, labels=rep("", length(b)), tcl=-.1)

#dev.off()

9.4 Secondary gains

We can also time secondary gains for certain configurations. This is always possible as long only one allele is gained, such as 3:1. If two alleles are gained this required additional assumptions. For 3:2 the typical assumption would be 1:1 -> 2:2 -> 3:2. For 4:2 the assumption is 1:1 -> 2:1 -> 4:2. Here we only consider gains of a single allele, which can be uniquely timed. These analyses were conducted by Lara Jerman. Here we load her data.

9.4.1 Load data

Load preprocessed data, aggregated by chromsome

load("two_gain_times.RData")
doubleGains <- as.data.frame(T.i.F)
m <- paste(doubleGains$sample, doubleGains$cnMaj, doubleGains$cnMin, doubleGains$chromosome, sep="_")
s <- split(doubleGains[,c("sample","tumor_type","T1_raw","T2_raw","n_mutations")], m)
doubleGainsAggregated <- Reduce("rbind",sapply(s, function(x) {
                    data.frame(sample=x$sample[1], tumor_type=x$tumor_type[1], T1_raw=weighted.mean(x$T1_raw, x$n_mutations),T2_raw=weighted.mean(x$T2_raw, x$n_mutations), n_mutations=sum(x$n_mutations))
                }, simplify=FALSE))

9.4.2 Timing of primary and secondary gains

First plot all samples and chromosomes, first versus second gain.

x <- doubleGainsAggregated$T1_raw/pmax(1, doubleGainsAggregated$T2_raw)
y <- doubleGainsAggregated$T2_raw/pmax(1, doubleGainsAggregated$T2_raw)
o <- order(doubleGainsAggregated$n_mutations, decreasing=TRUE)
plot(x[o], 
        y[o], 
        bg=tissueColors[as.character(donor2type[sample2donor[names(finalSnv)[doubleGainsAggregated$sample[o]]]])], pch=21,
        col=tissueBorder[as.character(donor2type[sample2donor[names(finalSnv)[doubleGainsAggregated$sample[o]]]])],
        xlab="Time [mutations], first gain",
        ylab="Time [mutations], second gain",
        cex=sqrt(doubleGainsAggregated$n_mutations[o]/500)+0.1,
        lwd=0.5)

t <- table(doubleGainsAggregated$sample)

The distribution is surprisingly independent, as one might have expected multiple copies of the same allele to be gained at the same time.

Now split by timing class - no obvious trend.

names(timingClass) <- names(finalSnv)
par(mfrow=c(2,2))
for(l in grep("uninformative",levels(timingClass), invert=TRUE, value=TRUE)){
    w <- which(timingClass[doubleGains$sample]==l)
    o <- intersect(order(doubleGainsAggregated$n_mutations, decreasing=TRUE),w)
    plot(x[o], 
            y[o], 
            bg=tissueColors[as.character(donor2type[sample2donor[names(finalSnv)[doubleGainsAggregated$sample[o]]]])], pch=21,
            col=tissueBorder[as.character(donor2type[sample2donor[names(finalSnv)[doubleGainsAggregated$sample[o]]]])],
            xlab="Time [mutations], first gain",
            ylab="Time [mutations], second gain",
            cex=sqrt(doubleGainsAggregated$n_mutations[o]/500)+0.1)
    title(main=l, line=0, font.main=1)
}

Clusters are often caused by individual samples:

par(mfrow=c(5,5))
for(i in as.numeric(names(t)[t>5])[1:25]){
    w <- which(doubleGainsAggregated$sample==i)
    plot(x[w],y[w], 
            col=tissueBorder[as.character(donor2type[sample2donor[names(finalSnv)[doubleGainsAggregated$sample[w]]]])], 
            bg=tissueColors[as.character(donor2type[sample2donor[names(finalSnv)[doubleGainsAggregated$sample[w]]]])], 
            type='p', xlim=c(0,1), ylim=c(0,1), 
            xlab="time 1",
            ylab="time 2",
            pch=21,
            cex=sqrt(doubleGainsAggregated$n_mutations[w]/500+0.1))
    
}

9.4.3 Relative latency

To formalise the observation that the second gains occur seemingly uniformly after the first, calculate and plot the relative latency.

w <- y < 1 & x > 0
r <- ((y-x)/(1-x))
h <- hist(r[w], breaks=seq(0,1,0.025), plot=FALSE)
e <- d <- density(r[w], from=-1, to=2, bw="SJ")
i <- which(d$x < 0)
d$y[max(i) + seq_along(i)] <-  d$y[max(i) + seq_along(i)] + d$y[rev(i)]
i <- which(d$x > 1)
d$y[min(i) -  seq_along(i)] <-  d$y[min(i) -  seq_along(i)] + d$y[i]
i <- which(d$x >0 & d$x < 1)
d <- list(x=d$x[i], y=d$y[i])
plot(h$mids,h$counts/sum(h$counts),  pch=19, col='grey',ylim=c(0,max(h$counts/sum(h$counts))), xlab="Latency of second gain", ylab="Relative frequency", type='h')

The majority of secondary gains indeed appear to occur independently after the second. Only about 17% occur in close succession.

plot(d$x,cumsum(d$y * diff(d$x)[1]), xlim=c(0,1), type='l', ylim=c(0,1), xlab="Relative time of second gain", ylab="CDF")

9.4.3.1 Figure 1h

It is perhaps instructive to assess the relative latency by timing class. WGD appears underrepresented in cases with synchronous double gains.

c <- cut(r[w], 20)
t <- table(timingClass[doubleGainsAggregated$sample[w]],c)
barplot(t[names(colTime),]/sum(t), border=NA, col=colTime, width=1/24, space=0.2, names.arg=rep("",20, bty="L", yaxs="s"))
.par()
axis(side=1, line=0.2)

xlxs output

Figure1h <- createSheet(Figure1, "Figure1h")
addDataFrame(t[names(colTime),], Figure1h)

Lastly, simulate higher order gains to cross-check whether the inference is credible.

n <- 100
c <- 40
purity=0.7
bb <- GRanges(seqnames=1, IRanges(1,1e8), major_cn=3, minor_cn=1, clonal_frequency=purity, n.snv_mnv=n)
bb$total_cn <- bb$major_cn+bb$minor_cn
t3 <- 0.8
t2 <- 0.8 # Simultaneous second amplification
d <- data.frame(cluster=1, n_ssms=1, proportion=purity)
cnStates <- defineMcnStates(bb,clusters=d, purity=purity)
pi <- matrix(c(4,2,1,0,1,0,0,0,1), byrow=TRUE, ncol=3) %*% c(1-t2,t2-t3,t3)
pi <- pi/sum(pi)
cnStates[[1]][,"P.m.sX"] <- pi
rho=0.01
cnStates[[1]][,"power.m.s"] <- 1-pbetabinom(2, size=c, prob=cnStates[[1]][,"f"], rho=rho )

bb$timing_param <- cnStates
s <- simplify2array(mclapply(1:50, function(foo){
                    set.seed(foo)
                    v <- simulateMutations(bb, n=40)
                    bb0 <- bb
                    bb0$timing_param <- NULL
                    L <- computeMutCn(v, bb0, clusters=d, purity=purity, rho=rho, n.boot=0)
                    L$P[[1]]
                }))
boxplot(t(s[2:3,"T.m.sX",]), at=3:2, xlab="Simulated time point", names=c("t2","t3"))
points(3:2,c(t2-t3, t3), col='red', pch=19)

l <- s[2,"T.m.sX",]/(1-s[3,"T.m.sX",])
x <- seq(0,1,0.05)
plot(x[-1]+x[2]/2, as.numeric(prop.table(table(cut(l[l<1], x)))), xlab="Latency", ylab="frequency", type='h')
axis(side=1)

9.4.3.2 Figure 1g

We also calculate how often higher order gains occur in each timing class. To this end, to a tally of all copy number gains.

cn <- do.call("rbind", sapply(names(finalBB), function(n){
                    bb <- finalBB[[n]]
                    data.frame(sample=n, chr=seqnames(bb), width=width(bb), M=bb$major_cn, m=bb$minor_cn)}, simplify=FALSE))

How does this relate to the length of the segments?

t <- table(pmin(cn$M,3) ,  pmax(3,round(log10(cn$width),1)), timingClass[cn$sample])
x <- as.numeric(colnames(t))
plot(NA,NA, type='p', col=colTime[1], pch=16, ylim=c(0,0.8), xlim=range(10^x), xlab="Length of segment", ylab="Proportion >2 allelic copies", log='x')
for(n in dimnames(t)[[3]]) {
    y <- as.numeric(t[4,,n]/colSums(t[3:4,,n]))
    lines(10^x,y, type='p', col=paste0(colTime[n],"44"), pch=16, cex=1)#sqrt(colSums(t[3:4,,i]/1000)))
    lines(10^x, predict(loess(y ~x)), col=colTime[n], lwd=2)
}

Plot the fraction of samples with double gains for each timing class. Asynchronous samples appear overrepresented.

tt <- mg14:::asum(t[,x>=7,],2)
o <- names(colTime)
p <- tt[4,o]/colSums(tt[3:4,o])
ci <- sapply(c(0.025, 0.975), qbeta, 0.025, shape1=tt[4,o]+1, shape2=tt[3,o]+1)
barplot(p, col=colTime, border=NA, las=2, ylab="Proportion >2 allelic copies", names=sub("ormative","",sub("near-diploid", "ND", names(colTime))), ylim=c(0,0.4)) -> b
segments(b, ci[,1], b, ci[,2])

Produce xlsx output

Figure1g <- createSheet(Figure1, "Figure1g")
addDataFrame(t(tt[3:4,o]), Figure1g)

10 Chronological WGD & MRCA

Here we calculate approximate real time estimates of WGD and MRCA using only CpG>TpG mutations, which are found in every tumoyr type and vary relatively little between samples.

10.1 CpG>TpG branch lengths and mutation rates

The approximate chronological timing is basd only CpG>TpG mutations, which universally occur in all tissues, are used as a precautionary measure. We first study the burden of CpG>TpG mutations (RpCpG>RpTpG in Melanoma) in each sample across tissues and as a function of age. This enables us to remove some hypermutant samples and derive a range of possible mutation rate increase.

Branch lengths need to be adjusted for time-dependent copy number as well as the structure of the subclonal phyllogeny.

10.1.1 Prelim

Get the age of every donor.

age <- clinicalData$donor_age_at_diagnosis
names(age) <- clinicalData$icgc_donor_id

Exclude these cancer types:

typeNa <- gsub("\t","",strsplit("Bone-Cart
                        Breast-LobularCa
                        Breast-DCIS
                        Lymph-NOS
                        Myeloid-MDS
                        Cervix-AdenoCa", "\n")[[1]])

10.1.1.1 Effective (time-averaged) genome size

Calculate effective genome size, i.e. time-averaged ploidy from mutation copy numbers. This is useful to convert mutation counts into approximate rates.

effGenome <- unlist(mclapply(finalSnv, function(vcf) {
                    w <- info(vcf)$CLS!="subclonal"
                    if(donor2type[sample2donor[meta(header(vcf))$META["ID",]]]=="Skin-Melanoma")
                        w <- w & isDeaminationNoUV(vcf)
                    else
                        w <- w & isDeamination(vcf)
                    2/avgWeights(vcf[na.omit(w)])
                }))
names(effGenome) <- names(finalSnv)

10.1.1.2 Power per (sub)clone

Also calculate the power to detect variants for different subclones to extrapolate their true branch length.

finalPower <- sapply(names(finalBB), function(n) {
            x <- finalBB[[n]]
            f <- finalClusters[[n]]$proportion
            for(i in 1:length(x)){
                t <- x$timing_param[[i]]
                p <- t[match(f, t[,"cfi"]), "power.s"]
                if(!is.null(p)) if(all(!is.na(p))) break
            }
            if(is.null(p)) return(rep(NA, length(f)))
            return(p)
        })
#plot(unlist(lapply(wccClusters[names(finalSnv)], `[[`, "n_ssms")),unlist(lapply(finalClusters[names(finalSnv)], `[[`, "n_ssms"))/ unlist(finalPower), log='xy',
#       xlab="Cluster size WCC (consensus)", ylab="Cluster size MutationTime.R") 

10.1.1.3 Branch lengths

The following calculates the length of the trunk (clonal mutations) and the depth of the MRCA, scaled by power and using a densitly branching subclonal phylogeny. Scaling branches by 1/f assumes the densest possible branching topology and this the shortest latency.

branchDeam <- t(simplify2array(mclapply(finalSnv, function(vcf) {
                            n <- meta(header(vcf))$META["ID",]
                            if(donor2type[sample2donor[n]]=="Skin-Melanoma")
                                w <- isDeaminationNoUV(vcf)
                            else
                                w <- isDeamination(vcf)
                            if(sum(w)==0) return(c(0,0))
                            p <- info(vcf)$pSub[w]; 
                            n.subclonal <- aggregate(p, list(info(vcf)$CNF[w]), sum, na.rm=TRUE)
                            m <- apply(abs(outer(n.subclonal$Group.1, finalClusters[[n]]$proportion, `-`)),1,which.min) # Match to subclones
                            p.subclonal <- finalPower[[n]][m] # Power of subclones
                            b.subclonal <- n.subclonal$x %*% (n.subclonal$Group.1 / p.subclonal) / max(n.subclonal$Group.1) # Subclonal branch, power adjusted & 1/f-scaled
                            b.clonal <- sum(1-p, na.rm=TRUE)/finalPower[[n]][1] # Clonal branch (trunk), power adjusted & 1/f-scaled
                            c(b.subclonal, b.clonal)})))

d <- droplevels(donor2type[sample2donor[names(finalSnv)]])
typesSubclones <- setdiff(levels(d), c(typeNa, names(which(table(d)<5))))

nClones <- sapply(finalClusters, nrow)

Comparison to linear branching in which the branch lengths of all subclonal populations is added. This constitutes the other extreme, corresponding to the maximal latency.

branchDeamLinear <- t(simplify2array(mclapply(finalSnv, function(vcf) {
                            if(donor2type[sample2donor[meta(header(vcf))$META["ID",]]]=="Skin-Melanoma")
                                w <- isDeaminationNoUV(vcf)
                            else
                                w <- isDeamination(vcf)
                            if(sum(w)==0) return(c(0,0))
                            n <- meta(header(vcf))$META["ID",]
                            if(donor2type[sample2donor[n]]=="Skin-Melanoma")
                                w <- isDeaminationNoUV(vcf)
                            else
                                w <- isDeamination(vcf)
                            if(sum(w)==0) return(c(0,0))
                            p <- info(vcf)$pSub[w]; 
                            n.subclonal <- aggregate(p, list(info(vcf)$CNF[w]), sum, na.rm=TRUE)
                            m <- apply(abs(outer(n.subclonal$Group.1, finalClusters[[n]]$proportion, `-`)),1,which.min) # Match to subclones
                            p.subclonal <- finalPower[[n]][m] # Power of subclones
                            b.subclonal <- n.subclonal$x %*% (1 / p.subclonal)  # Subclonal branch, power adjusted 
                            b.clonal <- sum(1-p, na.rm=TRUE)/finalPower[[n]][1] # Clonal branch (trunk), power adjusted
                            c(b.subclonal, b.clonal)})))

Compare branching and linear topologies:

f <- (branchDeam[,1] / finalPloidy) / rowSums(branchDeam / cbind(finalPloidy, effGenome))
l <- (branchDeamLinear[,1]/ finalPloidy)/rowSums(branchDeamLinear / cbind(finalPloidy, effGenome))
t <- donor2type[sample2donor[names(finalSnv)]]
plot(f, l, xlab="Subclonal branch length (branching)", ylab="Subclonal branch length (linear)", pch=21, bg=tissueColors[t], col=tissueBorder[t], cex=tissueCex[t])
abline(0,1, lty=2)

quantile(l/f, na.rm=TRUE)
##        0%       25%       50%       75%      100% 
##  1.000000  1.230433  1.787160  2.324245 18.979107
quantile(l, na.rm=TRUE)
##         0%        25%        50%        75%       100% 
## 0.00000000 0.01893107 0.09696972 0.27966436 0.98292792
quantile(f, na.rm=TRUE)
##          0%         25%         50%         75%        100% 
## 0.000000000 0.009730081 0.045141939 0.135827609 0.955712890

10.1.2 Average mutation rates

Here we convert branch lengths into average mutation rates (assuming no change, ie avgmu=n/age). First study relation of mutation burden to age, then calculate average mutation rates, exclude hypermutators and also samples with tumour in normal 1% for further analyses.

Plot a large overview:

rateDeam <- cc <- list()
remove <- "8454fe53-869d-41c8-b0c8-a7929d00eec3" # a cell line, add more samples in the following
par(mfrow=c(6,6), mar=c(3,3,2,1),mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="L", xpd=FALSE, las=1, xpd=FALSE)
for(n in typesSubclones){
    i <- d==n
    tt0 <- branchDeam[i,]/cbind(finalPloidy[i], effGenome[i]) / 3#cbind(nClones[i]-1, 1)/3 # 3Gb Haploid genome
    tt0[is.infinite(tt0)|is.nan(tt0)] <- 0
    yy <- rowSums(tt0)
    a <- age[sample2donor[names(finalSnv)[i]]]
    xx <- a
    r <- yy/xx 
    m <- median(r[TiN[names(xx)] <= 0.01 & ! is.na(TiN[names(xx)])],na.rm=TRUE)
    rateDeam[[n]] <- r
    try({
                w <- (r-m)^2/m^2 <= 2^2 & TiN[names(xx)] <= 0.01 & ! is.na(TiN[names(xx)])
                remove <- c(remove, names(which(!w)))
                plot(xx, yy, bg=tissueColors[n], col=tissueBorder[n], pch=NA, log='', xlab="Age at diagnosis", ylab="SNVs/Gb", main=n, ylim=c(0,pmin(1000,max(yy, na.rm=TRUE))), xlim=c(0,max(age, na.rm=TRUE)),  cex.main=1)
                #par(xpd=NA)
                #segments(x0=0,y0=0, xx, yy, col=tissueLines[n], lty=tissueLty[n])
                points(xx, yy, bg=tissueColors[n], col=ifelse(w,tissueBorder[n], tissueColors[n]), pch=ifelse(w,21,4))
                abline(0, m, lty=3)
                #lines(c(x0,2*x0), c(0,1))
                #print(paste(n,cor(xx[w],yy[w],use='c'), cor(xx[w],tt0[w,] %*% c(0.2,1), use='c'), sep=": "))
                l <- lm(yy~xx, data=data.frame(yy=yy[w],xx=xx[w], row.names=as.character(seq_along(yy[w]))))
                f <- (summary(l))
                p <- predict(l,newdata=data.frame(xx=seq(0,100,1)), se=TRUE)
                polygon(c(seq(0,100,1),rev(seq(0,100,1))), c(p$fit - 2*p$se.fit, rev(p$fit+2*p$se.fit)), border=tissueBorder[n], col=paste0(tissueColors[n],"44"))
                v <- which(!is.na(xx[w]*yy[w]))
                cc[[n]] <- cbind(f$coefficients, f$cov.unscaled * f$sigma^2, coef(nnls::nnls(cbind(1,xx[w][v]), yy[w][v])))
            })
}
## Warning in predict.lm(l, newdata = data.frame(xx = seq(0, 100, 1)), se = TRUE): prediction from a rank-deficient fit may
## be misleading
## Warning in cbind(...): number of rows of result is not a multiple of vector length (arg 3)
n <- names(rateDeam)
qRateDeam <- sapply(rateDeam, function(r){
            m <- median(r[TiN[sample2donor[names(r)]] <= 0.01 & ! is.na(TiN[sample2donor[names(r)]])],na.rm=TRUE)
            w <- (r-m)^2/m^2 <= 2^2 & TiN[sample2donor[names(r)]] <= 0.01 & ! is.na(TiN[sample2donor[names(r)]])
            quantile(r[w], na.rm=TRUE)})
plot(sapply(rateDeam, median, na.rm=TRUE), pch=NA , ylab="SNVs/Gb/yr", main="CpG>TpG rate", ylim=c(0, max(qRateDeam)), cex.main=1, xaxt='n', xlab="Tumour type")
segments(seq_along(rateDeam),qRateDeam["0%",],seq_along(rateDeam), qRateDeam["100%",], col=tissueLines[n], lty=1)
points(sapply(rateDeam, median, na.rm=TRUE), pch=21, col=tissueBorder[n], bg=tissueColors[n])

length(remove)
## [1] 743

Plot the average rates as barplot across tissues. Relatively little variation.

par(mar=c(6,3,1,1))
o <- order(qRateDeam["50%",])
barplot(qRateDeam["50%",][o], col=tissueColors[colnames(qRateDeam)][o], border=tissueLines[colnames(qRateDeam)][o], las=2,names.arg=rep("",ncol(qRateDeam)) , ylab="CpG>TpG rate [SNVs/Gb/yr]", ylim=c(0, max(qRateDeam))) -> b
mg14::rotatedLabel(b, labels=colnames(qRateDeam)[o])
segments(b, qRateDeam["50%",][o], b, qRateDeam["100%",][o], col=tissueLines[colnames(qRateDeam)][o], lwd=2)
segments(b, qRateDeam["0%",][o], b, qRateDeam["50%",][o], col=tissueBorder[colnames(qRateDeam)][o], lwd=2)

10.1.2.1 Extended Data Figure 8a

Plot the copynumber and ITH-adjusted mutation burden versus age and add a loess fit.

tt0 <- branchDeam/cbind(finalPloidy, effGenome) / cbind(nClones-1, 1)/3 # 3Gb Haploid genome
tt0[is.infinite(tt0)|is.nan(tt0)] <- 0
m <- sapply(rateDeam, function(r){m <- median(r[TiN[sample2donor[names(r)]] <= 0.01 & ! is.na(TiN[sample2donor[names(r)]])],na.rm=TRUE)})
s <- rowSums(tt0)#/m[as.character(donor2type[sample2donor[names(finalSnv)]])] 
s[remove] <- NA
t <- donor2type[sample2donor[names(finalSnv)]]
x <- age[sample2donor[names(finalSnv)]]
plot(x,s, bg=tissueColors[t], pch=21, ylim=c(0,1000), col=tissueBorder[t], cex=tissueCex[t]*2/3, lwd=0.25, xlab="Age", ylab="SNVs/Gb")
p <- predict(loess(s~x), newdata=sort(x, na.last=NA), se=TRUE)
r <- function(x) c(x, rev(x))
polygon(r(sort(x, na.last=NA)), c(p$fit+2*p$se, rev(p$fit-2*p$se)), col="#00000044", border=NA)
lines(sort(x, na.last=NA),p$fit)

#s <- 12/8; dev.copy2pdf(file="timeSubcloneAgePancan.pdf", width=2*s, height=2*s, pointsize=8*s)

xlsx

ExtendedDataFigure8a <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8a")
tab <- data.frame(age=x, `CpG>TpG/Gb`=s, tumour_type=t)
addDataFrame(tab, ExtendedDataFigure8a)

Is there a positive intercept in a linear mutation v age fit?

a <- simplify2array(cc[!names(cc) %in% c("Myeloid-AML","Bone-Epith")])
all(a[1,1,] + 2*a[1,2,]>0 )
## [1] TRUE

Positive slope?

all(na.omit(a[2,1,] + 2*a[2,2,]>0))
## [1] TRUE
plot(a[1,1,], a[2,1,], col=tissueColors[dimnames(a)[[3]]], pch=NA, xlab="Offset", ylab="SNVs/Gb/yr")
segments(a[1,1,], a[2,1,] - a[2,2,],a[1,1,], a[2,1,]+a[2,2,], col=tissueLines[dimnames(a)[[3]]], pch=19)
segments(a[1,1,]-a[1,2,], a[2,1,], a[1,1,]+a[1,2,], a[2,1,], col=tissueLines[dimnames(a)[[3]]], pch=19)
points(a[1,1,], a[2,1,], pch=21, bg=tissueColors[dimnames(a)[[3]]], col=tissueLines[dimnames(a)[[3]]])
abline(h=0, lty=3)
abline(v=0, lty=3)

The two quantities above can be used to calculate a fraction of mutations due to linear accumulation

par(mar=c(6,3,1,1))
ma <- sapply(split(age, donor2type[names(age)]), median, na.rm=TRUE)
fm <- pmax(a[2,7,],0)*ma[dimnames(a)[[3]]]/(pmax(0,a[2,7,])*ma[dimnames(a)[[3]]] + pmax(0,a[1,7,]))*100
o <- order(fm)
fmq <- sapply(names(fm), function(n){
            aa <- mvtnorm::rmvnorm(10000, mean=a[,1,n], sigma=a[,5:6,n] )
            aa <- aa[aa[,1]>=0 & aa[,2]>=0,]
            quantile(pmax(aa[,2],0)*ma[n]/(pmax(0,aa[,2])*ma[n] + pmax(0,aa[,1])), c(0.025, 0.975))
        }) *100
barplot(fm[o], col=tissueColors[dimnames(a)[[3]]][o], border=tissueLines[dimnames(a)[[3]]][o], las=2,names.arg=rep("",length(fm)) , ylab="Age-attributed mutations [%]") -> b
mg14::rotatedLabel(b, labels=names(fm[o]))
segments(b, fm[o], b, fmq[2,o], col=tissueLines[dimnames(a)[[3]]][o], lwd=2)
segments(b, fmq[1,o], b, fm[o], col=tissueBorder[dimnames(a)[[3]]][o], lwd=2)
abline(h=min(fmq[2,]))
abline(h=max(fmq[1,]))

10.1.3 Hierarchical Bayesian models of deamination rates

As the OLS fits per cancer type suggest a robust linear trend with small positive offsets, we repeat the analysis using a hierarchical Bayesian model. This enables us to share some information across cancer types, implicitly encode the positivity constraints and also propagate uncertainty into functions of the inferred parameters, such as the fraction of mutations due to linear accumulation.

Prepare data for rstan

library(rstan)
## Loading required package: ggplot2
## Loading required package: StanHeaders
## rstan (Version 2.17.2, GitRev: 2e1f913d3ca3)
## For execution on a local, multicore CPU with excess RAM we recommend calling
## options(mc.cores = parallel::detectCores()).
## To avoid recompilation of unchanged Stan programs, we recommend calling
## rstan_options(auto_write = TRUE)
y <- Reduce("c",rateDeam)
y <- y[!names(y) %in% remove]
x <- age[sample2donor[names(y)]]
y <- y*x
t <- donor2type[sample2donor[names(y)]]
d <- data.frame(x,y,t)
df <- d
df <- df[rowSums(is.na(df))==0,]
tt <- model.matrix(~droplevels(t)-1, data=df)

data <- list(n = nrow(df),
        p = ncol(tt),
        y = df$y,
        x = tt * df$x,
        t = tt
)

The actual stan model definition is defined in ./PCAWG-rates.stan:

data {
  int<lower=0> n;       // numbr of observations
  int<lower=0> p;          // number of types
  vector<lower=0>[n] y;    // mutations
  matrix[n,p] x;        // age
  matrix[n,p] t;        // tumour type
}

parameters {
  real<lower=0> sigma; // const. variance 
  real<lower=0> tau; // time-dep variance
  real<lower=0> alpha;      // alpha for slope
  real<lower=0> beta;  // beta for slope
  real<lower=0> gamma;
  real<lower=0> delta;
  vector<lower=0>[p] offset;
  vector<lower=0>[p] slope;
}

transformed parameters {
  vector[n] mu;
  vector[n] nu;
  vector[p] ones;
  ones = rep_vector(1, p);
  mu = x * slope + t * offset;
  nu = sqrt( square(x * ones)  * tau^2 + sigma^2);
}

model {
 slope ~ gamma(alpha, beta);
 offset ~ gamma(gamma, delta);
 y ~ normal(mu, nu); 
}

Now fit the model using Hamiltonian Monte Carlo

fit <- stan(
        file = "PCAWG-rates.stan",  # Stan program
        data = data,            # named list of data
        chains = 1,             # number of Markov chains
        warmup = 1000,          # number of warmup iterations per chain
        iter = 2000,            # total number of iterations per chain
        cores = 1,              # number of cores 
        refresh = 1000,         # show progress every 'refresh' iterations
        open_progress=FALSE,
        seed=42
)
## In file included from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/config.hpp:39:0,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/math/tools/config.hpp:13,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/core/var.hpp:7,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/core/gevv_vvv_vari.hpp:5,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/core.hpp:12,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/mat.hpp:4,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math.hpp:4,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/src/stan/model/model_header.hpp:4,
##                  from file171073724d95a.cpp:8:
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/config/compiler/gcc.hpp:186:0: warning: "BOOST_NO_CXX11_RVALUE_REFERENCES" redefined [enabled by default]
##  #  define BOOST_NO_CXX11_RVALUE_REFERENCES
##  ^
## <command-line>:0:0: note: this is the location of the previous definition
## In file included from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/base.hpp:28:0,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array.hpp:21,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/numeric/odeint/util/multi_array_adaption.hpp:29,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/numeric/odeint.hpp:61,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/prim/arr/functor/integrate_ode_rk45.hpp:17,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/prim/arr.hpp:38,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/prim/mat.hpp:298,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/mat.hpp:12,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math.hpp:4,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/src/stan/model/model_header.hpp:4,
##                  from file171073724d95a.cpp:8:
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/concept_checks.hpp: In static member function ‘static void boost::multi_array_concepts::detail::idgen_helper<N>::call(Array&, const IdxGen&, Call_Type)’:
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/concept_checks.hpp:42:43: warning: typedef ‘index_range’ locally defined but not used [-Wunused-local-typedefs]
##        typedef typename Array::index_range index_range;
##                                            ^
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/concept_checks.hpp:43:37: warning: typedef ‘index’ locally defined but not used [-Wunused-local-typedefs]
##        typedef typename Array::index index;
##                                      ^
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/concept_checks.hpp: In static member function ‘static void boost::multi_array_concepts::detail::idgen_helper<0ul>::call(Array&, const IdxGen&, Call_Type)’:
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/concept_checks.hpp:53:43: warning: typedef ‘index_range’ locally defined but not used [-Wunused-local-typedefs]
##        typedef typename Array::index_range index_range;
##                                            ^
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/BH/include/boost/multi_array/concept_checks.hpp:54:37: warning: typedef ‘index’ locally defined but not used [-Wunused-local-typedefs]
##        typedef typename Array::index index;
##                                      ^
## In file included from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/core.hpp:44:0,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/mat.hpp:4,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math.hpp:4,
##                  from /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/src/stan/model/model_header.hpp:4,
##                  from file171073724d95a.cpp:8:
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/core/set_zero_all_adjoints.hpp: At global scope:
## /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5/StanHeaders/include/stan/math/rev/core/set_zero_all_adjoints.hpp:14:17: warning: ‘void stan::math::set_zero_all_adjoints()’ defined but not used [-Wunused-function]
##      static void set_zero_all_adjoints() {
##                  ^
## 
## SAMPLING FOR MODEL 'PCAWG-rates' NOW (CHAIN 1).
## 
## Gradient evaluation took 0.01 seconds
## 1000 transitions using 10 leapfrog steps per transition would take 100 seconds.
## Adjust your expectations accordingly!
## 
## 
## Iteration:    1 / 2000 [  0%]  (Warmup)
## Iteration: 1000 / 2000 [ 50%]  (Warmup)
## Iteration: 1001 / 2000 [ 50%]  (Sampling)
## Iteration: 2000 / 2000 [100%]  (Sampling)
## 
##  Elapsed Time: 269.94 seconds (Warm-up)
##                290.9 seconds (Sampling)
##                560.84 seconds (Total)

Collect parameters

s <- summary(fit, pars=c("offset","slope"))$summary
ab <- array(s, dim=c(ncol(tt),2,10), dimnames=list(levels(droplevels(t)), c("a","b"), colnames(s)))

Summary plot

plot(x,y, bg=tissueColors[t], pch=21, ylim=c(0,1000), col=tissueBorder[t], cex=tissueCex[t]*2/3, lwd=0.25, xlab="Age", ylab="SNVs/Gb")
for(i in 1:nrow(ab))
    abline(ab[i,1,"50%"], ab[i,2,"50%"], col=tissueLines[levels(droplevels(t))[i]], lty=tissueLty[levels(droplevels(t))[i]])

10.1.3.1 Extended Data Figure 8c

Plot inferred rates and offsets with 95% credible intervals.

plot(ab[,1,"50%"], ab[,2,"50%"], col=tissueColors[dimnames(ab)[[1]]], pch=NA, xlab="Offset", ylab="SNVs/Gb/yr", xlim=range(ab[,1,c("2.5%","97.5%")]), ylim=range(ab[,2,c("2.5%","97.5%")]))
segments(ab[,1,"50%"], ab[,2,"2.5%"],ab[,1,"50%"], ab[,2,"97.5%"], col=tissueLines[dimnames(ab)[[1]]], pch=19)
segments(ab[,1,"2.5%"], ab[,2,"50%"],ab[,1,"97.5%"], ab[,2,"50%"], col=tissueLines[dimnames(ab)[[1]]], pch=19)
points(ab[,1,"50%"], ab[,2,"50%"], pch=21, bg=tissueColors[dimnames(ab)[[1]]], col=tissueLines[dimnames(ab)[[1]]])
abline(h=0, lty=3)
abline(v=0, lty=3)

a <- extract(fit, pars="offset")$offset
b <- extract(fit, pars="slope")$slope
colnames(a) <- colnames(b) <- levels(droplevels(t))

xlsx ouput

ExtendedDataFigure8c <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8c")
addDataFrame(ab, ExtendedDataFigure8c)

10.1.3.2 Extended Data Figure 8b

Create a large overview panel with all data points used and the Bayesian linear fits with 95% CIs.

par(mfrow=c(6,6), mar=c(3,3,2,1),mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="L", xpd=FALSE, las=1, xpd=FALSE)
d <- droplevels(t)
for(n in levels(d)){
    i <- d==n
    yy <- y[i]
    xx <- x[i]
    m <- median(yy/xx, na.rm=TRUE)
    try({
                plot(xx, yy, bg=tissueColors[n], col=tissueBorder[n], pch=21, log='', xlab="Age at diagnosis", ylab="SNVs/Gb", main=n, ylim=c(0,pmin(1000,max(yy, na.rm=TRUE))), xlim=c(0,max(x, na.rm=TRUE)),  cex.main=1)
                #points(xx, yy, bg=tissueColors[n], col=ifelse(w,tissueBorder[n], tissueColors[n]), pch=ifelse(w,21,4))
                abline(0, m, lty=3)
                x0 <- seq(0,100,1)
                p <- apply(sapply(x0, function(x) a[,n] + b[,n]*x), 2, quantile, c(0.025,0.975), na.rm=TRUE)
                polygon(c(x0,rev(x0)), c(p["2.5%",], rev(p["97.5%",])), border=tissueBorder[n], col=paste0(tissueColors[n],"44"))
            })
}

xlsx outputs.

ExtendedDataFigure8b <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8b")
tab <- data.frame(age=x, `CpG>TpG/Gb`=y, tumour_type=d)
addDataFrame(tab, ExtendedDataFigure8b)

Calculate the fraction of mutations due to linear accumulation using the inferred parameters and propagate the error from the HMC samples.

q <- sapply(colnames(a), function(n){
            w <- which(t==n & !is.na(y))
            f <- sapply(w, function(j) x[j] * b[,n] / (a[,n] + x[j] * b[,n]))
            quantile(rowMeans(f), c(0.025, 0.25, .5,.75,.975))
        })*100

qPanCan=quantile(rowMeans(do.call("cbind",sapply(colnames(a), function(n){
                                    w <- which(d==n & !is.na(y))
                                    f <- sapply(w, function(j) x[j] * b[,n] / (a[,n] + x[j] * b[,n]))
                                }))),
        c(0.025, 0.25, .5,.75,.975))*100

10.1.3.3 Extended Data Figure 8e

Plot the fraction of mutations due to linear accumulation using bar plots with 95% CIs, sorted.

par(mar=c(6,3,1,1))
o <- order(q["50%",])
barplot(q["50%",o], col=tissueColors[colnames(q)][o], border=tissueLines[colnames(q)][o], las=2,names.arg=rep("",length(q["50%",])) , ylab="Age-attributed mutations [%]", ylim=c(0,100)) -> b
mg14::rotatedLabel(b, labels=names(q["50%",o]))
segments(b, q["50%",][o], b, q["97.5%",o], col=tissueLines[colnames(q)][o], lwd=2)
segments(b, q["2.5%",o], b, q["50%",][o], col=tissueBorder[colnames(q)][o], lwd=2)
abline(h=min(q["97.5%",]), lty=3)
abline(h=max(q["2.5%",]), lty=3)

#abline(h=qPanCan["50%"], lty=4)

xlsx output

ExtendedDataFigure8e <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8e")
addDataFrame(t(q), ExtendedDataFigure8e)

Quickly assess whether this fraction qualitative agrees with simulations using a 5x range increase occuring between 0-15yrs prior to sampling.

set.seed(42)
x <- df$x
a <-  runif(length(x), pmax(0.5, 1-15/x), 1) #
r <- rgamma(length(x), 10, 10)
y <- rpois(length(x), (a + (1-a)*5) * r * x * 6 * 0.2)/6
y[x < 40] <- NA
plot(x,y, ylim=c(0,max(y, na.rm=TRUE)), xlab="Age", ylab="SNVs/Gb", pch=21, bg="grey", lwd=0.5)
f <- lm(y~x)
summary(f)
## 
## Call:
## lm(formula = y ~ x)
## 
## Residuals:
##     Min      1Q  Median      3Q     Max 
## -16.580  -5.146  -0.878   4.171  31.728 
## 
## Coefficients:
##             Estimate Std. Error t value Pr(>|t|)    
## (Intercept)  5.31347    1.01438   5.238 1.82e-07 ***
## x            0.21375    0.01583  13.504  < 2e-16 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## Residual standard error: 7.311 on 1696 degrees of freedom
##   (280 observations deleted due to missingness)
## Multiple R-squared:  0.09708,    Adjusted R-squared:  0.09655 
## F-statistic: 182.4 on 1 and 1696 DF,  p-value: < 2.2e-16
c <- coef(f)
abline(c)

mean(c[1] / (c[1]+ x*c[2]), na.rm=TRUE)
## [1] 0.3297523

10.2 CpG>TpG acceleration in relapse samples

Load a table with data from cancer relapse samples in 8 tissues. This data was collected from 8 separate studies and compiled by Santiago Gonzalez.

relapse <- read.table("../data/2018_05_acceleration.txt", header=TRUE, sep="\t")
head(relapse)
##        ID   Ttype  Acc_CpG  Acc_max  Acc_min Primary.purity Relapse.purity Primary_CpG_muts Relapse_CpG_muts    shared
## 1 DO46329 Ovarian 5.843684 7.304605 5.478454             NA             NA              405              604 0.8765432
## 2 DO46344 Ovarian 7.977252 8.863613 7.977252             NA             NA              341              409 0.8416422
## 3 DO46366 Ovarian 7.165330 8.429799 7.165330             NA             NA              442              710 0.9162896
## 4 DO46368 Ovarian 6.705564 7.058488 5.646791             NA             NA              332              622 0.8674699
## 5 DO46374 Ovarian 5.217451 5.217451 2.820244             NA             NA              751              964 0.8788282
## 6 DO46380 Ovarian 3.469097 3.854552 3.276369             NA             NA              444              540 0.6666667
##   Primary_age Relapse_time Primary_ploidy Relapse_ploidy Primary_effGenome
## 1          52     4.372348            1.6             NA          1.527314
## 2          46     1.149897            1.8             NA          1.793000
## 3          65     5.500342            1.7             NA          1.788664
## 4          57     7.425051            1.9             NA          1.663099
## 5          69     3.750856            3.7             NA          3.212753
## 6          51     3.178645            1.8             NA          1.693212

10.2.1 Branch lengths

Now caculate branch lengths to visualise these data, adjusted for (time-dependent) ploidy. To this end first the ploidy in the primary branch.

p <- relapse$Primary_ploidy
p[is.na(p)] <- 2

And for the MRCA. Impute effective genome if timing is missing using typical scale factor for effective genome (this is just for graphical purposes).

m <- p
m[m>2.8 & is.na(relapse$Primary_effGenome)] <- m[m>2.8 & is.na(relapse$Primary_effGenome)] * 0.7 
m[m>2.8 & !is.na(relapse$Primary_effGenome)] <- relapse$Primary_effGenome[m>2.8 & !is.na(relapse$Primary_effGenome)]

Ploidy in the relapse branch

r <- relapse$Relapse_ploidy
r[is.na(r)] <- relapse$Primary_ploidy[is.na(r)]
r[is.na(r)] <- 2

Branch lengths, adjusted for ploidy

b_mrca <- relapse$Primary_CpG_muts * relapse$shared / 3 /m
b_relapse <- (relapse$Relapse_CpG_muts - relapse$Primary_CpG_muts * relapse$shared)/ 3/ r
b_primary <- (relapse$Primary_CpG_muts - relapse$Primary_CpG_muts * relapse$shared) / 3 /p

Corresponding time points

t_primary <- relapse$Primary_age
t_relapse <- t_primary + relapse$Relapse_time
t_mrca <- 0.5 * (t_primary * b_mrca/(b_mrca + b_primary) + pmin(t_primary, t_relapse * b_mrca/(b_mrca + b_primary) ))

10.2.1.1 Extended Data Figure 8f,g

#pdf("relapse_accel_branch.pdf", pointsize=8, width=4, height=2)
.par()
par(mfrow=c(1,2))
for(t in c("Ovarian", "Breast")){
    w <- which(relapse$Ttype==t)
    r <- relapse[w,]
    plot(r$Primary_age+r$Relapse_time, r$Relapse_CpG_muts, ylim=c(0,150), xlim=c(0,80), pch=NA, xlab="Age", ylab="CpG>TpG/Gb")
    tt <- c(Ovarian="Ovary-AdenoCa",Breast="Breast-AdenoCa")[t]
    title(main=tt, line=0)
    c <- tissueColors[tt]
    #mrca <- r$Primary_CpG_muts*r$shared
#points(mrca_time, mrca)
    segments(0,0, t_mrca[w],b_mrca[w], col=c)
    segments(t_mrca[w], b_mrca[w], t_primary[w], (b_mrca+b_primary)[w], col=c)
    segments(t_mrca[w], b_mrca[w], t_relapse[w], (b_mrca+b_relapse)[w], col=c)
    points(t_primary[w], b_mrca[w]+b_primary[w], pch=21, bg=c, col="white")
    points(t_relapse[w], (b_mrca+b_relapse)[w], pch=21, bg=c, col="white")
}

#dev.off()

ExtendedDataFigure8f <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8f")
tab <- data.frame(t_mrca, t_primary, t_relapse, b_mrca, b_primary, b_relapse, type=relapse$Ttype, ID=relapse$ID)
addDataFrame(tab[which(relapse$Ttype=="Ovarian"),], ExtendedDataFigure8f)
ExtendedDataFigure8g <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8g")
addDataFrame(tab[which(relapse$Ttype=="Breast"),], ExtendedDataFigure8g)

10.2.2 Mutation rate increase

The acceleration - or mutation rate increase - is effectively the ratio of the ploidy adjusted CpG>TpG branch-length in the relase sample versus the MRCA. See Supplementary Methods for details.

10.2.2.1 Extended Data Figure 8h

Plot the acceleration values inferred from CpG>TpG mutations in each branch

#pdf('foo.pdf', 2,2, pointsize=8)
.par()
par(mar=c(5,3,1,1))
x <- relapse$Ttype
levels(x) <- c("Myeloid-AML","Breast-AdenoCa","CNS-LGG","Liver-HCC","Lung-AdenoCa","CNS-Medullo","Lymph-BNHL","Ovary-AdenoCa")
x <- as.character(x)
c <- tissueColors; c["CNS-LGG"] <- "black"
b <- tissueBorder; b["CNS-LGG"] <- "white"
t <- tissueCex; t["CNS-LGG"] <- 1
j <- jitter(as.numeric(factor(x)))
plot(NA,NA, xlim=c(.5,8), xaxt="n", xlab="", ylab="Acceleration", ylim=c(0,15))
segments(j, relapse$Acc_min, j, relapse$Acc_max, col=c[x])
points(Acc_CpG ~ j, data=relapse, bg=c[x], col=b[x], pch=21, cex=t[x])
abline(h=1, lty=3)
mg14::rotatedLabel(labels=levels(factor(x)))

#dev.off()

ExtendedDataFigure8h <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8h")
addDataFrame(relapse, ExtendedDataFigure8h)

The surplus of mutations in relapse samples (after adjusting for the depth of branching) shows a very good correlation with the time difference between primary and relapse sample

#pdf("relapse_time.pdf", pointsize=8, width=2, height=2)
.par()
plot(t_relapse - t_primary, b_relapse-b_primary, xlim=c(0,13), xlab="Time to relapse", ylab="Surplus in relapse, CpG>TpG/Gb", pch=16)
w <- t_relapse - t_primary < 10
abline(lm((b_relapse - b_primary)[w] ~ (t_relapse-t_primary)[w]))
legend("topright", c(paste("rho =",round(cor(t_relapse - t_primary, b_relapse-b_primary, method='s'),2)),
                paste("p =",signif(cor.test(t_relapse - t_primary, b_relapse-b_primary, method='s')$p.value,1))), bty="n")
## Warning in cor.test.default(t_relapse - t_primary, b_relapse - b_primary, : Cannot compute exact p-value with ties

#dev.off()

10.3 Normal tissue mutation rates

Here we compare the infereed CpG>TpG baseline rates to data from four different studies on normal tissues.

10.3.1 Normal blood CSC

Data of blood colonies from a 59yr-old individual. Taken from Lee-Six et al. Nature 2018

hsc_data <- read.table(gzfile("../data/Shearwater_calls_FDR0.95_all_muts.txt.gz"), header=TRUE, sep="\t")
ct <- which((hsc_data$REF=="C" & hsc_data$ALT=="T") | (hsc_data$REF=="G" & hsc_data$ALT=="A" ))
v <- VRanges(seqnames = hsc_data$X.CHROM, ref=hsc_data$REF, alt=hsc_data$ALT, ranges=IRanges(hsc_data$POS, width=1))
tnc=scanFa(file=refFile, resize(granges(v), 3,fix="center"))
cpgtpg <- grepl("(A.CG)|(T..CG)", paste(alt(v),tnc))
n_cpgtpg <- colSums(hsc_data[cpgtpg,5:144], na.rm=TRUE)
normal_hsc_cpgtpg <- quantile(n_cpgtpg/59/6, c( 0.5, 0.025,0.975))

10.3.2 Normal colon

Colonic crypts of several individuals. Data taken from Lee-Six et al. bioRxiv 2018, https://www.biorxiv.org/content/10.1101/416800v1.

colon_sbs <- read.table("../data/model_input_with_CtoTatCpG.txt", header=TRUE, sep="\t")
foo <- as.data.frame(summary(lm(CtoTatCpG/6 ~ age-1, data=colon_sbs))$coef)
normal_colon_cpgtpg <- quantile(colon_sbs$CtoTatCpG/colon_sbs$age/6, c( 0.5, 0.025,0.975))#c(foo$Estimate, foo$Estimate - 2*foo$`Std. Error`, foo$Estimate + 2*foo$`Std. Error`)
plot(colon_sbs$age, colon_sbs$CtoTatCpG/6, xlab="Age", ylab="CpG>TpG/Gb", pch=16)

10.3.3 Endometrium

Normal endometrial glands. Data from Moore et al., bioRxiv 2018, https://www.biorxiv.org/content/10.1101/505685v1.

tab <- read.table("../data/endom_subs.txt", sep="\t", header=TRUE)
quantile(tab$C.T.at.CpG/tab$Age, c(0.5, 0.025, 0.975))/6
##       50%      2.5%     97.5% 
## 1.1830286 0.5780461 2.1285985
normal_endometrium_cpgtpg <- quantile(tab$C.T.at.CpG/tab$Age, c(0.5, 0.025, 0.975))/6
plot(tab$Age, tab$C.T.at.CpG/6, xlab="Age", ylab="CpG>TpG/Gb", pch=16)

10.3.4 Normal skin

Data for a single normal skin biopsy from Martincorena et al., Science 2015

foo <- read.table("../ref/PD20399be_wg_caveman_annotated_with_dinucs_for_mg14.txt", header=TRUE, sep="\t")
is_cpgtpg <-  grepl("(A.CG[C,T])|(T.[A,G]CG)", paste(foo$mut,foo$trinuc_Ref))
normal_skin_cpgtpg <- sum(is_cpgtpg * foo$VAF)/0.375/55/6 # Adjust for YCG fraction, age and genome

normal_cpgtpg <- rbind(`Myeloid-MPN`=normal_hsc_cpgtpg,
        `Skin-Melanoma`=c(normal_skin_cpgtpg,NA,NA) ,
        `Uterus-AdenoCa`=normal_endometrium_cpgtpg,
        `ColoRect-AdenoCa`=normal_colon_cpgtpg)

x <- abind::abind(cancer=ab[rownames(normal_cpgtpg), "b",colnames(normal_cpgtpg)], normal=normal_cpgtpg[,], along=3)
x["Skin-Melanoma",,] <-x["Skin-Melanoma",,]

10.3.5 Extended Data Figure 8d

Side-by-side comparison of the median rates of normal tissues with linear (ie presumed baseline) rates from cancer samples with 95% CI.

#pdf("cancer_normal_cpgtpg.pdf", 2.5,2.5, pointsize=8)
par(mar=c(3,3,1,1), bty="L", mgp=c(2,.5,0), tcl=-0.25, las=1)
t(barplot(t(x[,"50%",]), beside=TRUE, col=rep(tissueColors[rownames(normal_cpgtpg)], each=2), density=rep(c(NA,36), nrow(normal_cpgtpg)), ylim=c(0,max(x, na.rm=TRUE)),
                ylab="Mutation rate [CpG>TpG/Gb/yr]", names.arg=c("Blood","Skin","Uterus","Colon"))) -> b
legend("topleft", c("Cancer","Normal"), fill="black", density=c(NA,36), bty="n")
#foo <- do.call("rbind", list(
#               data.frame(cpgtpg=n_cpgtpg/59/6, x=b[1,2]), 
#               data.frame(cpgtpg=normal_skin_cpgtpg, x=b[2,2]),
#               data.frame(cpgtpg=tab$C.T.at.CpG/tab$Age/6, x=b[3,2]),
#               data.frame(cpgtpg=colon_sbs$CtoTatCpG/colon_sbs$age/6, x=b[4,2])))
#points(cpgtpg ~ jitter(x,.5), data=foo, cex=.5, pch=16, col="#00000044")
segments(b,x[,"2.5%",],b,x[,"97.5%",])

#dev.off()

xlsx output

ExtendedDataFigure8d <- createSheet(ExtendedDataFigure8, "ExtendedDataFigure8d")
addDataFrame(x, ExtendedDataFigure8d)

10.4 MRCA

Now we time the latency of the most recent common ancestor (MRCA), or more accurately we compute the time between MRCA and the last observable subclone. An implicit assumption is that that the latency between the emergence of the last detectable subclone and diagnosis is short with respect to the time between fertilisation and diagnosis.

10.4.1 Functions

Acceleration values to simulate

accel <- c(1,2.5,5,7.5,10,20)
names(accel) <- paste0(accel, "x")

The actual timing using the age of each individual. This assumes that the branch length of the subclonal period is to be devided by the acceleration (ie mutation rate increase). We propagate Poisson error to obtain CIs.

set.seed(42)
d <- droplevels(donor2type[sample2donor[names(finalSnv)]])

computeSubclonesTimeAbs <- function(l, b) {
    i <- d==l
    tt0 <- b[i,]/cbind(finalPloidy[i], effGenome[i]) #/ cbind(nClones[i]-1, 1)
    resB <- sapply(1:1000, function(foo){ ## Assess the impact of Poisson fluctuations on numbers
                tt <- matrix(rpois(length(tt0), lambda=tt0), ncol=ncol(tt0))
                res <- sapply(accel, function(a)  tt[,1]/a/rowSums(tt/rep(c(a,1), each=nrow(tt)))) * age[sample2donor[names(finalSnv)[i]]]
                colnames(res) <- paste0(accel, "x")
                #res[res==0] <- NA
                res}, simplify='array')
    res <- sapply(accel, function(a)  tt0[,1]/a/rowSums(tt0/rep(c(a,1), each=nrow(tt0)))) * age[sample2donor[names(finalSnv)[i]]]
    colnames(res) <- paste0(accel, "x") 
    resCI <- apply(resB,1:2, quantile, c(0.1,0.9), na.rm=TRUE)
    arr <- abind::abind(res, resCI, along=1)
    rownames(arr)[1] <- "hat"
    arr <- aperm(arr, c(2,1,3))
    tt0[is.infinite(tt0)|is.nan(tt0)] <- 0
    r <- which(rowSums(b[i,]) < 50 ) ## Exclude samples with less than 50 subs 
    arr[r,,] <- NA
    return(arr)
}

10.4.2 Timing

Calculate for linear and branching topologies

subclonesTimeAbs <- mclapply(typesSubclones, computeSubclonesTimeAbs, b=branchDeam)
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## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced
subclonesTimeAbsLinear <- mclapply(typesSubclones, computeSubclonesTimeAbs, b=branchDeamLinear)
## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

## Warning in rpois(length(tt0), lambda = tt0): NAs produced

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names(subclonesTimeAbsLinear) <- names(subclonesTimeAbs) <- typesSubclones

Buest guess acceleration values (usually 5x, except Ovarian and CNS).

guessAccel <- sapply(subclonesTimeAbs, function(x) "5x")
guessAccel["Ovary-AdenoCa"] <- guessAccel["Liver-HCC"] <- "7.5x"
guessAccel[grep('CNS', names(guessAccel))] <- "2.5x"

10.4.2.1 Extended Data Figure 9f

Plot the inferred latencies per sample with overlaid boxplots.

u <- setdiff(names(finalSnv)[uniqueSamples], remove)
par( mar=c(7,3,1,1), mgp=c(2,.5,0), tcl=0.25,cex=1, bty="L", xpd=FALSE, las=1)
qSubclone <- sapply(subclonesTimeAbs, function(x) apply(x[,"hat",][rownames(x)%in%u,,drop=FALSE], 2, quantile, c(0.05,0.25,0.5,0.75,0.95), na.rm=TRUE), simplify='array')
a <- "5x"
subclonesTimeAbsType <- sapply(names(subclonesTimeAbs), function(n) {x <- subclonesTimeAbs[[n]]; x[,,guessAccel[n]][setdiff(rownames(x),remove), 1:3, drop=FALSE]})
m <- diag(qSubclone["50%",guessAccel[dimnames(qSubclone)[[3]]],])#t[1,3,]
names(m) <- dimnames(qSubclone)[[3]]
nSubclones <- sapply(subclonesTimeAbsType, function(x) sum(!is.na(x[,1])))
m[nSubclones < 5] <- NA
o <- order(m, na.last=NA)
plot(NA,NA, xlim=c(0.5,length(m[o])), ylab="Years before diagnosis", xlab="", xaxt="n", yaxs="i", ylim=c(0,30))
abline(h=seq(10,20,10), col="#DDDDDD", lty=3)
x <- seq_along(m[o])
mg14::rotatedLabel(x, labels=names(sort(m)))
for(i in seq_along(o))try({
                n <- names(m)[o[i]]
                f <- function(x) x/max(abs(x))
                a <- guessAccel[n]
                bwd <- 0.8/2
                j <- if(length(na.omit(subclonesTimeAbsType[[o[i]]][,"hat"]))>1) f(mg14::violinJitter(na.omit(subclonesTimeAbsType[[o[i]]][,"hat"]))$y)/4 + i else i
                tpy <- 2
                segments(j, na.omit(subclonesTimeAbsType[[o[i]]][,"90%"]), j, na.omit(subclonesTimeAbsType[[o[i]]][,"10%"]), col=mg14::colTrans(tissueLines[n],tpy))
                points(j, na.omit(subclonesTimeAbsType[[o[i]]][,"hat"]), pch=21, col=mg14::colTrans(tissueBorder[n], tpy), bg=mg14::colTrans(tissueColors[n],tpy), 
                        cex=tissueCex[n]*2/3, lwd=1)
                rect(i-bwd,qSubclone["25%",a,n],i+bwd,qSubclone["75%",a,n], border=tissueLines[n],  col=paste(tissueColors[n],"44", sep=""))
                segments(i-bwd,qSubclone["50%",a,n],i+bwd,qSubclone["50%",a,n],col=tissueLines[n], lwd=2)
                segments(i,qSubclone["75%",a,n],i,qSubclone["95%",a,n],col=tissueLines[n], lwd=1.5)
                segments(i,qSubclone["5%",a,n],i,qSubclone["25%",a,n],col=tissueLines[n], lwd=1.5)
                f <- function(x) x/max(abs(x))
            })

#par(xpd=TRUE)
#s <- 12/8
#dev.copy2pdf(file="realTimeSubclone.pdf", width=6*s, height=3.5*3/5*s, pointsize=8*s)#' xlsx

xlsx output

ExtendedDataFigure9f <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9f")
tab <- data.frame(do.call("rbind", subclonesTimeAbsType))
tab$tumour_type <- donor2type[sample2donor[rownames(tab)]]
addDataFrame(tab, ExtendedDataFigure9f)

10.4.2.2 Figure 5c

Alternative representation of median acceleration across the range of simulated rate increases, per cancer type:

#pdf("realTimeSubcloneMed.pdf", width=6, height=2.225, pointsize=8)
u <- setdiff(names(finalSnv)[uniqueSamples], remove)
m <- qSubclone["50%","5x",]#t[1,3,]
names(m) <- dimnames(qSubclone)[[3]]
m[nSubclones < 5] <- NA
o <- order(m, na.last=NA)
n <- dimnames(qSubclone)[[3]]
par( mar=c(7,3,1,1), mgp=c(2,.5,0), tcl=0.25,cex=1, bty="L", xpd=FALSE, las=1)
plot(NA,NA, xlim=c(0.5,length(m[o])), ylab="Latency [yr]", xlab="", xaxt="n", yaxs="i", ylim=c(0,15))
abline(h=seq(10,20,10), col="#DDDDDD", lty=3)
x <- seq_along(m[o])
mg14::rotatedLabel(x, labels=names(sort(m)))
b <- .3
rect(seq_along(o)-b,qSubclone["50%","1x",o],seq_along(o)+b,qSubclone["50%","10x",o], col=paste(tissueColors[n[o]],"88", sep=""), border=1)
rect(seq_along(o)-b,qSubclone["50%","2.5x",o],seq_along(o)+b,qSubclone["50%","7.5x",o], col=paste(tissueColors[n[o]],"FF", sep=""), border=1)
rect(seq_along(o)-b,qSubclone["50%","20x",o],seq_along(o)+b,qSubclone["50%","10x",o], col=paste(tissueColors[n[o]],"22", sep=""), border=1)
segments(seq_along(o)-b,qSubclone["50%","5x",o],seq_along(o)+b,qSubclone["50%","5x",o])

#par(xpd=TRUE)
#s <- 12/8
#dev.copy2pdf(file="realTimeSubclone.pdf", width=6*s, height=3.5*3/5*s, pointsize=8*s)

sapply(subclonesTimeAbs, nrow)
##     Biliary-AdenoCa         Bladder-TCC         Bone-Benign          Bone-Epith      Bone-Osteosarc      Breast-AdenoCa 
##                  35                  23                  16                  10                  38                 198 
##          Cervix-SCC             CNS-GBM         CNS-Medullo           CNS-Oligo       CNS-PiloAstro    ColoRect-AdenoCa 
##                  18                  41                 146                  18                  89                  60 
##         Eso-AdenoCa            Head-SCC        Kidney-CCRCC        Kidney-ChRCC       Kidney-PapRCC           Liver-HCC 
##                  98                  57                 111                  45                  33                 326 
##        Lung-AdenoCa            Lung-SCC          Lymph-BNHL           Lymph-CLL         Myeloid-AML         Myeloid-MPN 
##                  38                  48                 107                  95                  11                  55 
##       Ovary-AdenoCa        Panc-AdenoCa      Panc-Endocrine       Prost-AdenoCa       Skin-Melanoma  SoftTissue-Leiomyo 
##                 113                 241                  85                 286                 107                  15 
## SoftTissue-Liposarc     Stomach-AdenoCa         Thy-AdenoCa      Uterus-AdenoCa 
##                  19                  75                  48                  51

xlsx output

Figure5c <- createSheet(Figure5, "Figure5c")
addDataFrame(aperm(qSubclone, c(3,1,2)), Figure5c)

10.4.2.3 Extended Data Figure 9g

Comparison of branching v linear

subclonesTimeAbsTypeLinear <- sapply(names(subclonesTimeAbsLinear), function(n) {x <- subclonesTimeAbsLinear[[n]]; x[,,guessAccel[n]][setdiff(rownames(x),remove), 1:3, drop=FALSE]})
qSubcloneLinear <- sapply(subclonesTimeAbsLinear, function(x) apply(x[,"hat",][rownames(x)%in%u,,drop=FALSE], 2, quantile, c(0.05,0.25,0.5,0.75,0.95), na.rm=TRUE), simplify='array')
n <- diag(qSubcloneLinear["50%",guessAccel[dimnames(qSubcloneLinear)[[3]]],])#t[1,3,]
names(n) <- dimnames(qSubcloneLinear)[[3]]
par( mar=c(5,3,3,10), mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="n", xpd=FALSE, las=1)
plot(c(rep(1, length(m)), rep(2, each=length(n))), c(m,n), bg=tissueColors[c(names(m), names(n))], pch=21, cex=1, xaxt="n", ylab="Years after MRCA", xlab="", xlim=c(0.5,2.5), ylim=c(0, max(n, na.rm=TRUE)))
segments(rep(1, each=length(m)), m, rep(2, each=length(n)), n,col=tissueLines[names(m)], lty= ifelse(sapply(subclonesTimeAbsType, nrow) <= 5, 3, tissueLty[names(m)]))
o <- order(n, na.last=NA)
y0 <- n[o]
y1 <- mg14:::mindist(n[o], diff(par('usr')[3:4])/30)
par(xpd=NA)
mtext(names(m)[o], at=y1, side=4 )
segments(2.1,y0,2.2,y0)
segments(2.2,y0,2.3,y1)
segments(2.3,y1,2.4,y1)
mg14::rotatedLabel(1:2, labels=c("Branching","Linear"))

xlsx output

ExtendedDataFigure9g <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9g")
addDataFrame(data.frame(branching=m, linear=n), ExtendedDataFigure9g)

Numbers per decade

yy <- do.call("rbind",subclonesTimeAbsType)
yy <- yy[setdiff(rownames(yy), remove),"hat"]
table(cut(yy, seq(0,60,10)))
## 
##  (0,10] (10,20] (20,30] (30,40] (40,50] (50,60] 
##    1863      27       4       2       1       0

10.5 WGD

The other landmark event that can be timed in approximately 30% of samples are whole-genome doublings.

10.5.1 Functions

Calculate relative timing estimates based on deaminations. The following function calculates molecular timing estimates by only evaluating CpG>TpG mutations, separately for aggreagated 2:0, 2:1, and 2:2 regions in each sample.

computeWgdParamDeam <- function(vcf, bb, clusters, purity){
    # 1. Find segments compatible with WGD
    min.dist <- 0.05
    m <- findMainCluster(bb)
    l <- pmin(bb$time.lo, bb$time - min.dist)
    u <- pmax(bb$time.up, bb$time + min.dist)
    o <- which(l <= m & u >= m)
    
    # 2. Find deaminations in compatible segments
    w <- which(info(vcf)$MajCN==2 & sapply(info(vcf)$CNID, length)==1 & isDeamination(vcf) & vcf %over% bb[o])
    if(donor2type[sample2donor[meta(header(vcf))$META["ID",]]]=="Skin-Melanoma")
        w <- intersect(w, which(isDeaminationNoUV(vcf)))
    v <- vcf[w]
    if(nrow(v)<=100) return(NULL) # At least 100 SNVs
    seqnames(rowRanges(v)) <- factor(3-info(v)$MinCN, levels=seqlevels(v))
    v <- sort(v)
    
    # 3. Merged CN segments
    b <- GRanges(1:3, IRanges(rep(1,3),rep(max(end(v)),3)), copy_number=4:2, major_cn=2, minor_cn=2:0, clonal_frequency=as.numeric(purity))
    
    # 4. Calculate times
    l <- computeMutCn(v, b, clusters, purity, isWgd=TRUE, n.boot=200, rho=0.01, xmin=3)
    b$n.snv_mnv <- l$n <- table(factor(info(v)$MinCN, levels=2:0))
    l$time <- bbToTime(b, l$P)
    return(l)
}

10.5.2 Timing

10.5.2.1 Molecular timing estimates

Takes ~1h.

wgdParamDeam <- mclapply(names(finalSnv)[isWgd], function(ID){
            try(computeWgdParamDeam(finalSnv[[ID]], finalBB[[ID]], clusters=finalClusters[[ID]], purity=finalPurity[ID]))
        })
names(wgdParamDeam) <- names(finalSnv)[isWgd]

Samples with insufficient data

void <- sapply(wgdParamDeam, function(x) is.null(x) | class(x)=="try-error")

Some checks

t <- sapply(wgdParamDeam[!void], function(x) {r <- as.matrix(x$time[,2:4]); rownames(r) <- x$time[,1];r}, simplify='array')
pairs(t(t[,"time",]))

10.5.2.2 Adjust for mutation rate increase

Now transform the molecular timing estimates (effectively branch lengths, scaled to 1) accounting for possinle late mutation rate increase of up to 20x. This returns a large array.

wgdTimeDeamAcc <- simplify2array(mclapply(names(wgdParamDeam[!void]), function(n) {
                    x <- wgdParamDeam[!void][[n]]
                    
                    T.clonal <- as.matrix(x$time[,2:4]) # Time of WGD as fraction of clonal                 
                    
                    n.subclonal <- aggregate(x$D[,"pSub"], list(x$D[,"CNF"]), sum)
                    m <- match(n.subclonal$Group.1, finalClusters[[n]]$proportion)
                    p.subclonal <- x$power.c[m] # Power of subclones
                    b.subclonal <- n.subclonal$x %*% (n.subclonal$Group.1 / p.subclonal) / max(n.subclonal$Group.1) # Subclonal branch, power adjusted & 1/f-scaled
                    b.clonal <- sum(1-x$D[,"pSub"])/p.subclonal['1'] # Clonal branch (trunk), power adjusted & 1/f-scaled
                    f.subclonal <- b.subclonal / (b.subclonal + b.clonal)
                    G.clonal <- sum (1-x$D$pSub)/sum((1-x$D$pSub)*x$D$MutCN/(x$D$MajCN + x$D$MinCN)) # Effective ploidy clonal, adjusted for timing
                    G.subclonal <- sum(x$D$pSub*(x$D$MajCN + x$D$MinCN))/ sum (x$D$pSub) # Final ploidy
                    if(is.nan(G.subclonal)) G.subclonal <- mean(x$D$MajCN + x$D$MinCN)
                    
                    ag <- age[sample2donor[names(finalBB)[isWgd][!void][j]]]
                    tmin <- max(0.5, 1-15/ag) # 15yrs or 50%, whatever smaller (median ~ 0.75 mutation time)
                    if(is.na(tmin)) tmin <- 0.8
                    ta=seq(tmin,1,l=20)
                    
                    .correctAccel <- function(T.clonal, f.subclonal, G.clonal, G.subclonal, ta, a){ # Helper function to correct accel a at clonal time ta
                        t1 <- T.clonal + (1-T.clonal) *(a-1)/a*ta #acc before dup
                        t2 <- T.clonal * (ta + a*(1-ta)) ## after
                        T.clonal.adj <- pmin(t1, t2) # as fraction of clonal
                        a.clonal <- ta + (1-ta)*a # effective rate, avg over clonal
                        T.subclonal.abs <- f.subclonal / G.subclonal / a
                        T.clonal.abs <- (1-f.subclonal) / G.clonal/ a.clonal
                        T.clonal.abs <- T.clonal.abs / (T.clonal.abs + T.subclonal.abs) # as fraction of all mutations
                        return(c(T.WGD=T.clonal.adj * T.clonal.abs, T.MRCA=T.clonal.abs))
                    }
                    
                    .correctAccelRand <- function(T.clonal, f.subclonal, G.clonal, G.subclonal, ta=seq(0.8,1,0.01), a=seq(1,10,1)){ # Helper to calculate range of accel a and times
                        sapply(ta, function(taa) sapply(a, function(aa) .correctAccel(T.clonal, f.subclonal, G.clonal, G.subclonal, taa, aa)), simplify='array')
                    }
                    
                    res <- apply(T.clonal, 1:2, .correctAccelRand, f.subclonal, G.clonal, G.subclonal, a=accel, ta=seq(tmin,1,l=20))
                    dim(res) <- c(2, length(accel), length(ta), dim(res)[-1])
                    return(res)
                    
                }))
dimnames(wgdTimeDeamAcc)[1:2] <- list(c("T.WGD","T.MRCA"), names(accel))
dimnames(wgdTimeDeamAcc)[[5]] <- colnames(wgdParamDeam[[1]]$time)[2:4] 
dimnames(wgdTimeDeamAcc)[[4]] <- levels(finalBB[[1]]$type)[c(3,1,2)]
dimnames(wgdTimeDeamAcc)[[6]] <- names(wgdParamDeam[!void])

n <- dimnames(wgdTimeDeamAcc)[[6]]
d <- droplevels(donor2type[sample2donor[n]])
s <- setdiff(levels(d), c(typeNa, names(which(table(d)<3))))

10.5.2.3 Convert to chronological time

Lastly calculate the corresponding real time by scaling with age at diagnosis

f <- function(n, mu, a, b){ ## asymmetric normal to interpolate CIs of the timing estimates
    r <- rnorm(n, sd=a)
    w <- which(r>0)
    r[w] <- r[w]*(b/a)[w]
    return(r + mu)
}
wgdTimeAbs <- sapply(s, function(l) {
            set.seed(42)
            i <- d==l & ! n %in% c(rownames(purityPloidy)[purityPloidy$wgd_uncertain])
            
            ## absolute time by multiplying with age at diagnosis
            absTimeSeg <- aperm((1-wgdTimeDeamAcc["T.WGD",,,,,i]) * rep(age[sample2donor[n]][i], each = prod(dim(wgdTimeDeamAcc)[c(2,3,4,5)])))
            w <- t(sapply(wgdParamDeam[n[i]], `[[`, "n")) #number of SNV as weights
            
            ## remove NA due to zero mutations
            for(c in 1:3)
                absTimeSeg[,,c,,][is.na(absTimeSeg[,,c,,]) & w[,c]==0] <- 0
            
            ## weighted average over 2+0, 2+1 and 2+2 segments
            absTime <- (absTimeSeg[,,1,,] * w[,1] + absTimeSeg[,,2,,] * w[,2] + absTimeSeg[,,3,,] * w[,3]) / rowSums(w) 
            rownames(absTime) <- n[i]
            
            ## Median over acceleration onset
            absTimeMed <- apply(absTime, c(1,2,4), median, na.rm=TRUE) 
            colnames(absTimeMed) <- c("hat","up","lo")
            
            ## Simulate distribution sampling from timing onset and mutation time CI 
            ts <- sapply(1:1000, function(foo) {ax <- sample(1:20,1); matrix(f(length(absTime[,"time",ax,]),a=abs(absTime[,"time",ax,] - absTime[,"time.up",ax,])/2, b=abs(absTime[,"time.lo",ax,]-absTime[,"time",ax,])/2, mu=absTime[,"time",ax,]), nrow=dim(absTime)[1])}, simplify='array')
            me <- apply(ts, 1:2, quantile, c(0.1, 0.8), na.rm=TRUE) # 80% CIs
            absTimeMed[,"lo",] <- (me[1,,])
            absTimeMed[,"up",] <- (me[2,,])
            absTimeMed[,c(1,3,2),]
        }, simplify=FALSE)

10.5.2.4 Extended Data Figure 9a

First plot the inferred latency of WGD for each sample, per cancer type, overlaid by boxplots, using buest-guess acceleration.

par( mar=c(7,3,1,1), mgp=c(2,.5,0), tcl=0.25,cex=1, bty="L", xpd=FALSE, las=1)
u <- setdiff(names(finalSnv)[uniqueSamples], remove)
qWgd <- sapply(wgdTimeAbs, function(x) apply(x[rownames(x) %in% u,"hat",], 2, quantile, c(0.05,0.25,0.5,0.75,0.95), na.rm=TRUE), simplify='array')
nWgd <- sapply(wgdTimeAbs, function(x) sum(x[rownames(x) %in% u,"hat","1x"]!=0, na.rm=TRUE))
wgdTimeAbsType <- sapply(names(wgdTimeAbs), function(n) {x <- wgdTimeAbs[[n]]; x[,,guessAccel[n]][setdiff(rownames(x),remove), 1:3, drop=FALSE]})
m <- diag(qWgd["75%",guessAccel[dimnames(qWgd)[[3]]],])#t[1,3,]
names(m) <- dimnames(qWgd)[[3]]
o <- order(m, na.last=NA)
x <- seq_along(m[o])
plot(NA,NA, xlim=c(0.5,length(m[o])), ylim=c(0,max(do.call('rbind',wgdTimeAbsType)[,1], na.rm=TRUE)+5), ylab="Years before diagnosis", xlab="", xaxt="n", yaxs="i")
abline(h=seq(10,60,10), col="#DDDDDD", lty=3)
mg14::rotatedLabel(x, labels=names(sort(m)))
for(i in seq_along(o)){
    n <- names(m)[o[i]]
    f <- function(x) x/max(abs(x))
    a <- guessAccel[n]
    j <- f(mg14::violinJitter(na.omit(wgdTimeAbsType[[o[i]]][,"hat"]))$y)/4 + i #rank(na.omit(tWgdByType[[o[i]]][,"hat"]))/2/length(na.omit(tWgdByType[[o[i]]][,"hat"]))-0.25+i #
    tpy <- if(grepl("Skin|Lung", n)) 4 else 2
    segments(j, na.omit(wgdTimeAbsType[[o[i]]][,"up"]), j, na.omit(wgdTimeAbsType[[o[i]]][,"lo"]), col=mg14::colTrans(tissueLines[n],tpy), lty=tissueLty[n])
    points(j, na.omit(wgdTimeAbsType[[o[i]]][,"hat"]), pch=21, col=mg14::colTrans(tissueBorder[n], tpy), bg=mg14::colTrans(tissueColors[n],tpy), 
            cex=tissueCex[n]*2/3, lwd=1)
    bwd <- 0.8/2
    rect(i-bwd,qWgd["25%",a,n],i+bwd,qWgd["75%",a,n], border=tissueLines[n],  col=paste0(tissueColors[n],"44"))
    segments(i-bwd,qWgd["50%",a,n],i+bwd,qWgd["50%",a,n],col=tissueLines[n], lwd=2)
    segments(i,qWgd["75%",a,n],i,qWgd["95%",a,n],col=tissueLines[n], lwd=1.5)
    segments(i,qWgd["5%",a,n],i,qWgd["25%",a,n],col=tissueLines[n], lwd=1.5)
}

par(xpd=TRUE)
#s <- 12/8
#dev.copy2pdf(file="realTimeWgd.pdf", width=4*s, height=3.5*s, pointsize=8*s)

xlsx output

ExtendedDataFigure9a <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9a")
tab <- data.frame(do.call("rbind", wgdTimeAbsType))
tab$tumour_type <- donor2type[sample2donor[rownames(tab)]]
addDataFrame(tab, ExtendedDataFigure9a)

10.5.2.5 Figure 5b

Plot the median timing value for WGD, as a function of the unknown rate increase.

#pdf("realTimeWgdMed.pdf", width=4.5, height=3, pointsize=8)
u <- setdiff(names(finalSnv)[uniqueSamples], remove)
m <- qWgd["50%","5x",]#t[1,3,]
names(m) <- dimnames(qWgd)[[3]]
m[nWgd < 5] <- NA
o <- order(m, na.last=NA)
n <- dimnames(qWgd)[[3]]
par( mar=c(7,3,1,1), mgp=c(2,.5,0), tcl=0.25,cex=1, bty="L", xpd=FALSE, las=1)
plot(NA,NA, xlim=c(0.5,length(m[o])), ylab="Latency [yr]", xlab="", xaxt="n", yaxs="i", ylim=c(0,40))
abline(h=seq(10,20,10), col="#DDDDDD", lty=3)
x <- seq_along(m[o])
mg14::rotatedLabel(x, labels=names(sort(m)))
b <- .3
rect(seq_along(o)-b,qWgd["50%","1x",o],seq_along(o)+b,qWgd["50%","10x",o], col=paste(tissueColors[n[o]],"88", sep=""), border=1)
rect(seq_along(o)-b,qWgd["50%","2.5x",o],seq_along(o)+b,qWgd["50%","7.5x",o], col=paste(tissueColors[n[o]],"FF", sep=""), border=1)
rect(seq_along(o)-b,qWgd["50%","20x",o],seq_along(o)+b,qWgd["50%","10x",o], col=paste(tissueColors[n[o]],"22", sep=""), border=1)
segments(seq_along(o)-b,qWgd["50%","5x",o],seq_along(o)+b,qWgd["50%","5x",o])

xlsx output

Figure5b <- createSheet(Figure5, "Figure5b")
addDataFrame(aperm(qWgd, c(3,1,2)), Figure5b)

As a quality control, plot a range of extremely early samples

t <- do.call("rbind", wgdTimeAbsType)
o <- order(t[,"hat"], na.last=NA)
for(n in rownames(t)[tail(o, 20)])
    plotSample(n, title=paste0(sub("-.+","",n),", ", donor2type[sample2donor[n]], ", ",round(t[n,"hat"]),"yr"))

Numbers per decade

yy <- do.call("rbind",wgdTimeAbsType)
yy <- yy[setdiff(rownames(yy), remove),"hat"]
table(cut(yy, seq(0,60,10)))
## 
##  (0,10] (10,20] (20,30] (30,40] (40,50] (50,60] 
##     389      86      47      20      11       9

10.5.2.6 Extended Data Figure 9b

A panel of scatter plots showing WGD time as a function of age at diagnosis.

par(mfrow=c(6,6), mar=c(3,3,2,1),mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="L", xpd=FALSE, las=1)
for(i in seq_along(wgdTimeAbsType)){
    n <- names(wgdTimeAbsType)[i]
    y <- wgdTimeAbsType[[n]][,"hat"]
    x <- age[sample2donor[names(y)]]
    plot(x,x-y, pch=NA, bg=tissueColors[n], col=tissueBorder[n], xlab="Age [yr]", ylab="WGD [yr]", cex=tissueCex[n], xlim=c(0,90), ylim=c(0,90))
    segments(x, y0=x-wgdTimeAbsType[[n]][,"up"],y1=x-wgdTimeAbsType[[n]][,"lo"],col=tissueLines[n])
    points(x,x-y, pch=21, bg=tissueColors[n], col=tissueBorder[n], cex=tissueCex[n])
#   d <- density(na.omit(x), bw="SJ", from=0)
#   lines(d$x,d$y*100,col=tissueLines[n], lty=tissueLty[n])
#   d <- density(na.omit(x-y), bw="SJ", from=0)
#   lines(d$y*100, d$x,col=tissueLines[n], lty=tissueLty[n])
    rug(x, col=tissueLines[n],)
    rug(x-y, side=2, col=tissueLines[n])
    title(main=n, line=0, font.main=1, cex.main=1)
    abline(0,1, lty=3)
}

xlsx output

ExtendedDataFigure9b <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9b")
tab <- data.frame(do.call("rbind", wgdTimeAbsType))
tab$age <- age[sample2donor[rownames(tab)]]
tab$tumour_type <- donor2type[sample2donor[rownames(tab)]]
addDataFrame(tab, ExtendedDataFigure9b)

10.5.3 Deaminations v all mutations

For a rough comparison take the average co-amplification molecular time estimate calculated above against the estimate based on CpG>TpG mutations.

t <- sapply(wgdParamDeam[!void], function(x) x$time$time)
plot(timingInfo[colnames(t),'timeCoamp'], 
        colMeans(t), 
        cex=sqrt(nSub[colnames(t)]/10000), 
        pch=21,bg=tissueColors[donor2type[sample2donor[colnames(t)]]], 
        col=tissueBorder[donor2type[sample2donor[colnames(t)]]],
        xlab="time [all mutations]",
        ylab="time [CpG>TpG]")
abline(0,1, lty=3)

Plot difference as boxplots:

par(mar=c(6,4,1,1), xaxs='i')
boxplot(timingInfo[colnames(t),'timeCoamp'] - colMeans(t) ~ droplevels(donor2type[sample2donor[colnames(t)]]), 
        col=tissueColors[levels(droplevels(donor2type[sample2donor[colnames(t)]]))],
        na.rm=TRUE, las=2,
        lty=1,
        staplewex=0,
        pch=16,
        cex=0.8,
        ylab='time [all] - time [CpG>TpG]',
        names=NA
)
mg14::rotatedLabel(labels=levels(droplevels(donor2type[sample2donor[colnames(t)]])))
abline(h=0, lty=3)

10.5.4 Assessment of absolute mutation counts

To gain further insighe assess the distribution of the actual mutation numbers used for WGD timing across (2:0, 2:1, 2:2) regions

nDeam <- sapply(wgdParamDeam[!void], function(x) if(!is.null(x$n)) sum(x$n, na.rm=TRUE) else NA)

Number of deaminations only in 2:2 regions

nDeam22 <- sapply(wgdParamDeam[!void], function(x) if(!is.null(x$n)) as.numeric(x$n[1]) else NA)
w22 <- sapply(finalBB[isWgd][!void], function(bb) {
            w <- bb$major_cn==2 & bb$minor_cn==2 & !duplicated(bb)
            sum(as.numeric(width(bb)[w]), na.rm=TRUE)})
nDeam22 <- nDeam22/w22*1e9

Fraction of deam on 1 and 2 copies

d <- nDeam22 *  t(sapply(wgdParamDeam[!void], function(x) if(!is.null(x$P)) x$P[[1]][1:2,"P.m.sX"] else c(NA,NA)))
d[rownames(d) %in% remove] <- NA

Unadjusted time (inc. of subclonal mutations)

t0 <- colMeans(wgdTimeDeamAcc["T.WGD","1x",1,,"time",],na.rm=TRUE) # WGD
names(t0) <- dimnames(wgdTimeDeamAcc)[[6]]
m0 <- colMeans(wgdTimeDeamAcc["T.MRCA","1x",1,,"time",],na.rm=TRUE) # MRCA
names(m0) <- dimnames(wgdTimeDeamAcc)[[6]]

10.5.4.1 Figure 5a

Conceptual plot

#pdf("chronRateIncrease.pdf",2,2,pointsize=8)
.par()
a <- c(1,2.5,5,7.5,10, 20)
x <-  age[sample2donor["052665d1-ab75-4f40-be5a-b88154c8beed"]]
y <- nDeam["052665d1-ab75-4f40-be5a-b88154c8beed"]
t <- seq(0,x, by=0.1)
f <- function(t, ta, a){y <- t; y[t>ta] <- y[t>ta] + (y[t>ta] - min(y[t>ta]))*(a-1); y <- y/max(y)}
r <- sapply(a, function(aa){
            apply(sapply(x - seq(15,0,l=100), function(ta) f(t, ta, aa)),1,mean)
        })
## Warning in min(y[t > ta]): no non-missing arguments to min; returning Inf

## Warning in min(y[t > ta]): no non-missing arguments to min; returning Inf

## Warning in min(y[t > ta]): no non-missing arguments to min; returning Inf

## Warning in min(y[t > ta]): no non-missing arguments to min; returning Inf

## Warning in min(y[t > ta]): no non-missing arguments to min; returning Inf

## Warning in min(y[t > ta]): no non-missing arguments to min; returning Inf
plot(NA, NA, xlim=c(0,x), ylim=c(0,y), xlab="Age", ylab="CpG>TpG mutations")
for(i in seq_along(a)) lines(t, r[,i]*y)
w <- t0["052665d1-ab75-4f40-be5a-b88154c8beed"]
v <- m0["052665d1-ab75-4f40-be5a-b88154c8beed"]
segments(0,0, 0,w*y, col=set1[3]) 
text(10, w*y, "WGD", pos=3)
segments(0,w*y, 0, v*y, col=set1[4], lwd=2) # (WGD, MRCA)
text(0, v*y, "MRCA", pos=4)
segments(0,v*y, 0, y, col=set1[1], lwd=3) # (MRCA, diag)
for(i in seq_along(a)){
    x0 = t[which.min(abs(w - r[,i]))]
    segments(x0,0,x0,w*y, lty=3)
}
segments(0,w*y, x0, w*y, lty=3)

#dev.off()

10.5.4.2 Extended Data Figure 9c&d

Plot time v early and total number of mutations

y <- d[names(t0),]/6
x <- t0
t <- donor2type[sample2donor[names(t0)]]
plot(x,y[,2], bg=tissueColors[t], pch=21,  col=tissueBorder[t], cex=tissueCex[t]*1, lwd=0.5, xlab="Time", ylab="Early SNVs/Gb", log='')
p <- predict(loess(y[,2]~x, span=1), newdata=sort(x, na.last=NA), se=TRUE)
r <- function(x) c(x, rev(x))
polygon(r(sort(x, na.last=NA)), c(p$fit+2*p$se, rev(p$fit-2*p$se)), col="#00000044", border=NA)
lines(sort(x, na.last=NA),p$fit)

plot(x,y[,1]+y[,2], bg=tissueColors[t], pch=21,  col=tissueBorder[t], cex=tissueCex[t]*1, lwd=0.5, xlab="Time", ylab="Total SNVs/Gb", log='')
p <- predict(loess(rowSums(y)~x, span=1), newdata=sort(x, na.last=NA), se=TRUE)
r <- function(x) c(x, rev(x))
polygon(r(sort(x, na.last=NA)), c(p$fit+2*p$se, rev(p$fit-2*p$se)), col="#00000044", border=NA)
lines(sort(x, na.last=NA),p$fit)

#s <- 12/8; dev.copy2pdf(file="nDeam22Time.pdf", width=2*s, height=2*s, pointsize=8*s)

Reassuringly, the molecular timing estimate appears independent of the total mutation count and largely driven by a depletion of early variants (rather than an excess of late variants).

xlsx outputs

ExtendedDataFigure9c <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9c")
tab <- data.frame(`Molecular Time`=x, `Early CpG>TpG/Gb`=y[,2])
addDataFrame(tab, ExtendedDataFigure9c)
ExtendedDataFigure9d <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9d")
tab <- data.frame(`Molecular Time`=x, `Total CpG>TpG/Gb`=rowSums(y))
addDataFrame(tab, ExtendedDataFigure9d)

10.5.5 Acceleration adjustment relative to lowest quintile.

So far we used a fixed rate increase across samples. If some samples experienced a higher increase, this should manifest as a relative excess of mutations. Hence, calculate timing estimates using greater rate increase for samples with a higher CpG>TpG burden (per cancer type).

accelRelWgd <- sapply(names(wgdTimeAbs), function(n) {
            r <- rateDeam[[n]]
            x <- wgdTimeAbs[[n]]
            r0 <- quantile(r[!names(r) %in% remove], 0.20, na.rm=TRUE)
            a <- cut(pmin(pmax(1,(r/r0-0.9)/0.1),10), c(0,1.5,3.75,6.25,8.75,20), labels=c("1x","2.5x","5x","7.5x","10x"))
            print(table(a))
            names(a) <- names(r)
            ta <- sapply(rownames(x), function(ss) x[ss, "hat",a[ss]])
            ta
        })
## a
##   1x 2.5x   5x 7.5x  10x 
##   10    5    3    1   16 
## a
##   1x 2.5x   5x 7.5x  10x 
##    7    4    0    5    7 
## a
##   1x 2.5x   5x 7.5x  10x 
##    8    5    3    2   19 
## a
##   1x 2.5x   5x 7.5x  10x 
##   39   27   52   26   40 
## a
##   1x 2.5x   5x 7.5x  10x 
##    5    5    3    4    1 
## a
##   1x 2.5x   5x 7.5x  10x 
##   10    9   10    2   10 
## a
##   1x 2.5x   5x 7.5x  10x 
##   35   17   21    9   54 
## a
##   1x 2.5x   5x 7.5x  10x 
##   12   10   10    5   23 
## a
##   1x 2.5x   5x 7.5x  10x 
##   26   18   10   13   30 
## a
##   1x 2.5x   5x 7.5x  10x 
##   17    4    9    5   22 
## a
##   1x 2.5x   5x 7.5x  10x 
##   30   26   24   15   16 
## a
##   1x 2.5x   5x 7.5x  10x 
##    9    3    4    5   24 
## a
##   1x 2.5x   5x 7.5x  10x 
##   10    4    7    4    8 
## a
##   1x 2.5x   5x 7.5x  10x 
##   87  117   75   23   24 
## a
##   1x 2.5x   5x 7.5x  10x 
##    8    3    2    3   19 
## a
##   1x 2.5x   5x 7.5x  10x 
##   11    9   15    7    6 
## a
##   1x 2.5x   5x 7.5x  10x 
##   25   14   13   11   44 
## a
##   1x 2.5x   5x 7.5x  10x 
##   28   38   29   11    7 
## a
##   1x 2.5x   5x 7.5x  10x 
##   55   55   50   28   50 
## a
##   1x 2.5x   5x 7.5x  10x 
##   22    3    3    8   49 
## a
##   1x 2.5x   5x 7.5x  10x 
##   78   40   39   38   89 
## a
##   1x 2.5x   5x 7.5x  10x 
##   24   16   21    9   37 
## a
##   1x 2.5x   5x 7.5x  10x 
##    4    4    2    2    3 
## a
##   1x 2.5x   5x 7.5x  10x 
##    5    6    4    1    3 
## a
##   1x 2.5x   5x 7.5x  10x 
##   23    5    7    5   34 
## a
##   1x 2.5x   5x 7.5x  10x 
##   12   13    7    5   14
par(mar=c(3,3,1,1),mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="L", xpd=FALSE, las=1)
x <- Reduce("c",accelRelWgd)
y <- Reduce("c",sapply(wgdTimeAbs, function(x) x[,"hat","5x"]))

t <- donor2type[sample2donor[names(x)]]
plot(y+runif(length(y)),x+runif(length(y)), pch=21, bg=tissueColors[t], col=tissueBorder[t], cex=tissueCex[t]*1, lwd=0.5, xlab="Time (constant acceleration)", ylab="Time (sample-specific accel.)", log='')

#s <- 12/8; dev.copy2pdf(file="accelRelWgd.pdf", width=2*s, height=2*s, pointsize=8*s)

10.5.5.1 Extended Data Figure 9e

Compare quartiles of fixed and sample-specific timing approaches:

par(mar=c(3,3,1,1),mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="L", xpd=FALSE, las=1)
u <- setdiff(names(finalSnv)[uniqueSamples], remove)
qAccelRelWgd <- sapply(accelRelWgd, function(x){
            quantile(x[names(x) %in% u], na.rm=TRUE)
        })
t <- colnames(qAccelRelWgd)
plot(qWgd["50%","5x",], qAccelRelWgd["50%",], pch=NA,  xlab="Time [years], constant acceleration", ylab="Time [years], sample-specific accel.", xlim=c(0,30), ylim=c(0,30))
abline(0,1, lty=3)
segments(qWgd["25%","5x",], qAccelRelWgd["50%",],qWgd["75%","5x",], qAccelRelWgd["50%",], lty=tissueLty[t], col=tissueLines[t])
segments(qWgd["50%","5x",], qAccelRelWgd["25%",],qWgd["50%","5x",], qAccelRelWgd["75%",], lty=tissueLty[t], col=tissueLines[t])
points(qWgd["50%","5x",], qAccelRelWgd["50%",], bg=tissueColors[t], pch=21,  col=tissueBorder[t], cex=tissueCex[t], lwd=0.5)

#s <- 12/8; dev.copy2pdf(file="qAccelRelWgd.pdf", width=2*s, height=2*s, pointsize=8*s)

xlsx output

ExtendedDataFigure9e <- createSheet(ExtendedDataFigure9, "ExtendedDataFigure9e")
tab <- data.frame(fixed_acc=t(qWgd[2:4,"5x",]),sample_acc=t(qAccelRelWgd[2:4,]))
addDataFrame(tab, ExtendedDataFigure9e)

10.5.6 Average rate v time

Mutations per year vs time. If the mutation rate was constant, there should be a proportional increase due to the double opportunity to mutate after WGD.

par(mfrow=c(6,6), mar=c(3,3,2,1),mgp=c(2,.5,0), tcl=0.25,cex=1, bty="L", xpd=FALSE, las=1)
for(n in names(wgdTimeAbsType)){
    a <- age[sample2donor[rownames(wgdTimeAbsType[[n]])]]
    yy <- nDeam22[rownames(wgdTimeAbsType[[n]])]/a
    xx <- 1-t0[rownames(wgdTimeAbsType[[n]])]#y[[n]][,"hat"]/a
    try({
                l <- lm(yy ~ xx)
                x0 <- -l$coef[2]/l$coef[1]
                #print(x0)
                plot(xx, yy, bg=tissueColors[n], col=tissueBorder[n],, pch=21, log='', xlab="1-time [mutations]", ylab="SNVs/Gb/yr", main=n, ylim=c(0,max(yy, na.rm=TRUE)), xlim=c(0,max(xx, na.rm=TRUE)), cex.main=1)
                #abline(l, lty=3)
                #abline(l$coef[1], l$coef[1])
                m <- median(yy/(1+xx),na.rm=TRUE)
                abline(m, m, lty=3)
                #lines(c(x0,2*x0), c(0,1))
            })
}

10.6 MRCA v WGD

Compare timing estimates of MRCA and WGD. First, scatter of median

par( mar=c(4,3,1,1), mgp=c(2,.5,0), tcl=0.25,cex=1, bty="L", xpd=FALSE, las=1)
a <- "5x"
plot(qSubclone["50%",a,dimnames(qWgd)[[3]]], qWgd["50%",a,], col=tissueColors[dimnames(qWgd)[[3]]], pch=16, cex=2, xlab="Median time subclones", ylab="Median time WGD", xlim=c(0,5), ylim=c(0,10))

A dotplot may be more informative

par( mar=c(3,3,3,10), mgp=c(2,.5,0), tcl=-0.25,cex=1, bty="n", xpd=FALSE, las=1)
w <- "50%"

x <- diag(qSubclone[w,guessAccel[dimnames(qSubclone)[[3]]],])#t[1,3,]
names(x) <- dimnames(qSubclone)[[3]]
y <- diag(qWgd[w,guessAccel[dimnames(qWgd)[[3]]],])#t[1,3,]
names(y) <- dimnames(qWgd)[[3]]

plot(c(rep(1, dim(qSubclone)[3]), rep(2, each=dim(qWgd)[3])), c(x,y), bg=tissueColors[c(dimnames(qSubclone)[[3]], dimnames(qWgd)[[3]])], pch=21, cex=1, xaxt="n", ylab="Years before diagnosis", xlab="", xlim=c(0.5,2.5), ylim=c(0, max(y, na.rm=TRUE)))
segments(rep(1, each=dim(qWgd)[3]), x[dimnames(qWgd)[[3]]], rep(2, each=dim(qWgd)[3]), y,col=tissueLines[dimnames(qWgd)[[3]]], lty= ifelse(nWgd <= 5, 3, tissueLty[dimnames(qWgd)[[3]]]))
o <- order(y, na.last=NA)
y0 <- y[o]
y1 <- mg14:::mindist(y[o], diff(par('usr')[3:4])/30)
par(xpd=NA)
mtext(dimnames(qWgd)[[3]][o], at=y1, side=4 )
segments(2.1,y0,2.2,y0)
segments(2.2,y0,2.3,y1)
segments(2.3,y1,2.4,y1)
mg14::rotatedLabel(1:2, labels=c("Subclones","WGD"))

#segments(2.1,y0,2.3,y1)

#par(xpd=TRUE)
#s <- 12/8
#dev.copy2pdf(file="realTimeSubcloneWgd.pdf", width=2.5*s, height=3.5*s, pointsize=8*s)

10.7 Multi-sample cases

Lastly demonstrate concordance of our timing inferences based on multi-sample cases.

donor2sample <- split(names(finalBB),sample2donor[names(finalBB)])
donor2sample <- donor2sample[sapply(donor2sample, length)>1]

10.7.1 WGD

WGD - samples with * removed

par(mfrow=c(2,3), mar=c(4,3,2,1), cex=1)
for(n in names(donor2sample)){
    t <- as.character(donor2type[n])
    try({
                s <- wgdTimeAbs[[t]][,,guessAccel[t]]
                s <- s[rownames(s) %in% donor2sample[[n]],,drop=FALSE]
                if(length(s) ==0  ) next 
                if(nrow(s) ==1) next
                plot(s[,"hat"], ylim=c(0, 30), main = paste(n, t), ylab="Time WGD [yr]", xlab="", xaxt="n", xlim=c(0,nrow(s)+1), pch=NA)
                mg14::rotatedLabel(labels=paste0(sample2icgc[rownames(s)],ifelse(rownames(s) %in% remove, "*","")))
                segments(x0=1:nrow(s),y0=s[,'lo'], y1=s[,'up'], col=tissueLines[t],lty=tissueLty[t])
                points(s[,"hat"], pch=21, bg=tissueColors[t], cex=tissueCex[t], col=tissueBorder[t])
                abline(h= mean(s[,'hat']), col=tissueLines[t], lty=3)
            })
}

10.7.2 MRCA

MRCA - samples with * removed

par(mfrow=c(8,8), mar=c(4,3,2,1), cex=1)
for(n in names(donor2sample)){
    t <- as.character(donor2type[n])
    try({
                s <- subclonesTimeAbs[[t]][,,guessAccel[t]]
                s <- s[rownames(s) %in% donor2sample[[n]],,drop=FALSE]
                if(length(s) ==0  ) next 
                if(nrow(s) ==1) next
                plot(s[,"hat"], ylim=c(0, 20), main = paste(n, t), ylab="Time WGD [yr]", xlab="", xaxt="n", xlim=c(0,nrow(s)+1), pch=NA)
                mg14::rotatedLabel(labels=paste0(sample2icgc[rownames(s)],ifelse(rownames(s) %in% remove, "*","")))
                par(xpd=NA)
                segments(x0=1:nrow(s),y0=s[,'10%'], y1=s[,'90%'], col=tissueLines[t],lty=tissueLty[t])
                points(s[,"hat"], pch=21, bg=tissueColors[t], cex=tissueCex[t], col=tissueBorder[t])
                par(xpd=TRUE)
                abline(h= mean(s[,'hat']), col=tissueLines[t], lty=3)
            })
}

11 Mutation spectra

In this section we analyse changes of mutation spectra across the clonal timing categories.

11.1 Timed mutation spectra

Caclulate trinucleotide substitution spectra across all samples and all timing categories.

tncTime <- simplify2array(mclapply(finalSnv, function(vcf) table(tncToPyrimidine(vcf), info(vcf)$CLS)))

11.2 Early to late clonal changes

11.2.1 Distance-based

Calculate cosine distance between clonal and subclonal, plot 10 samples with strongest change and 1000 SNVs each

w <- which(apply(mg14:::asum(tncTime[,c(1,2),], 1)>1000, 2, all))
dEarlyLate <- sapply(w, function(i) {x <- tncTime[,,i]; 1-cosineDist(x[,1,drop=FALSE],x[,2,drop=FALSE])})

makeTitle <- function(n){
    d <- sample2donor[n]
    paste0(sample2icgc[n], ", ", donor2type[d], ", ", age[d], "yr")
}

11.2.2 Figure 4a and Extended Data Figure 6a

As examples show the 10 samples with the most striking changes.

n <- names(tail(sort(dEarlyLate),10))
sigCol <- sapply(c("#2196F3","#212121","#f44336","#BDBDBD","#8BC34A","#FFAB91"), rep,16)
ttl <- function(){
    l <- gsub("\\[|\\]||>.","", dimnames(tncTime)[[1]])
    mtext(text=l, at=b, las=2, cex=0.25, side=1)
    mtext(at=b[8+16*(0:5)], side=1,text=c("C>A","C>G","C>T","T>A","T>C","T>G"), las=1, line=1)
}
for(s in n){
    .par()
    par(mfrow=c(2,1), las=2, mar=c(2,3,2,1))    
    b <- barplot(as.numeric(tncTime[,1,s]), ylab="SNVs", main=makeTitle(s),col=sigCol,border=NA, font.main=1, las=2, cex.main=1)
    text(x=b[1],y=par("usr")[4], labels="early clonal", xpd=TRUE, adj=c(0,1))
    ttl()
    barplot(as.numeric(tncTime[,2,s]), ylab="SNVs", col=sigCol, border=NA,las=2)
    text(x=b[1],y=par("usr")[4], labels="late clonal", xpd=TRUE, adj=c(0,1))
    ttl()
}

xlsx output

Figure4a <- createSheet(Figure4, "Figure4a")
addDataFrame(as.data.frame(tncTime[,1:2,names(which(sample2icgc[n]=="SA434348"))]), Figure4a)
ExtendedDataFigure6a <- createSheet(ExtendedDataFigure6, "ExtendedDataFigure6a")
x <- tncTime[,1:2,n]
dimnames(x)[[3]] <- sample2icgc[n]
addDataFrame(as.data.frame(x), ExtendedDataFigure6a)

11.2.3 Test for spectral changes

To formatlise what constitutes a measureable change, calculate an LRT

tncLrt <- function(x){
    l1 <- dmultinom(x=x[,1], prob=x[,1], log=TRUE) + dmultinom(x=x[,2], prob=x[,2], log=TRUE)
    l0 <- dmultinom(x=x[,1], prob=x[,1]+x[,2], log=TRUE) + dmultinom(x=x[,2], prob=x[,1]+x[,2], log=TRUE)
    chisq <- 2*(l1-l0)
    df <- nrow(x)-1
    return(c(chisq=chisq, df=df, p=pchisq(chisq, df=df, lower.tail=FALSE)))
}

w <- which(colSums(tncTime[,1,])>0 & colSums(tncTime[,2,])>0) # Samples with at mutations in both categories
pEarlyLate <- apply(tncTime[,1:2,w],3, tncLrt)
table(p.adjust(pEarlyLate["p",], "bonf")<0.05)
## 
## FALSE  TRUE 
##  1327   525

Refit some mutational signatures, which have apparently been missed in the time-agnostic signature attribution

sbs <- read.csv("../ref/sigProfiler_SBS_signatures_2018_03_28.csv") # Official table

n <- names(which(sample2icgc=="SA434348"))
e <- nmSolve(tncTime[,,n], P = as.matrix(sbs[,grep("(SBS7[a-d])|SBS38|SBS40", colnames(sbs))]), maxIter=10000, tol=1e-6)
## 3333333333333456
a <- rbind(UV=colSums(e[1:4,]),e[5:6,])[,1:3]
apply(t(t(a)/colSums(a))*100,2,mg14:::roundProp)
##       clonal [early] clonal [late] clonal [NA]
## UV                89            23          72
## SBS38              2            37          11
## SBS40              9            40          17
n <- names(which(sample2icgc=="SA309724"))
e <- nmSolve(tncTime[,,n], P = as.matrix(sbs[,grep("SBS(2|13|4|5)$", colnames(sbs))]), maxIter=10000)
a <- rbind(APOBEC=colSums(e[c(1,4),]), e[2:3,])
apply(t(t(a)/colSums(a))*100,2,mg14:::roundProp)
##        clonal [early] clonal [late] clonal [NA] subclonal
## APOBEC             10            71          29        76
## SBS4               55             7          39         9
## SBS5               35            22          32        15
n <- names(which(sample2icgc=="SA100712"))
e <- nmSolve(tncTime[,,n], P = as.matrix(sbs[,grep("SBS(1|17.|18|5|40)$", colnames(sbs))]), maxIter=10000)
a <- rbind(`17`=colSums(e[c(3:4),]), e[-(3:4),])
apply(t(t(a)/colSums(a))*100,2,mg14:::roundProp)
##       clonal [early] clonal [late] clonal [NA] subclonal
## 17                 1            32          26        29
## SBS1              26             7          11         3
## SBS5              24            12          13         1
## SBS18             35            10          14        17
## SBS40             14            39          36        50

11.3 Clonal to subclonal changes

11.3.1 Distance

Calculate cosine distance between clonal and subclonal, plot 10 samples with strongest change and 1000 SNVs each

w <- which(mg14:::asum(tncTime[,1:3,], c(1,2))>1000 & mg14:::asum(tncTime[,4,], 1)>1000)
dClonalSubclonal <- sapply(w, function(i) {x <- tncTime[,,i]; 1-cosineDist(x[,1:3] %*% rep(1,3),x[,4,drop=FALSE])})

11.3.1.1 Figure 4b and Extended Data Figure 6b

n <- names(tail(sort(dClonalSubclonal),10))
for(s in n){
    .par()
    par(mfrow=c(2,1), las=2, mar=c(2,3,2,1))    
    b <- barplot(as.numeric(rowSums(tncTime[,1:3,s])), ylab="SNVs", main=makeTitle(s),col=sigCol,border=NA, font.main=1, las=2, cex.main=1)
    text(x=b[1],y=par("usr")[4], labels="clonal", xpd=TRUE, adj=c(0,1))
    ttl()
    barplot(as.numeric(tncTime[,4,s]), ylab="SNVs", col=sigCol, border=NA,las=2)
    text(x=b[1],y=par("usr")[4], labels="subclonal", xpd=TRUE, adj=c(0,1))
    ttl()
}

xlsx output

x <- tncTime[,c(1,4),n]
x[,1,] <- mg14:::asum(tncTime[,1:3,n], 2)
dimnames(x)[[3]] <- sample2icgc[n]
dimnames(x)[[2]][1] <- "clonal [early/late/NA]"
Figure4b <- createSheet(Figure4, "Figure4b")
addDataFrame(as.data.frame(x[,1:2,"SA557034"]), Figure4b)
ExtendedDataFigure6b <- createSheet(ExtendedDataFigure6, "ExtendedDataFigure6b")
addDataFrame(as.data.frame(x), ExtendedDataFigure6b)

11.3.2 Test

TNC LRT

w <- which(mg14:::asum(tncTime[,1:3,], c(1,2))>0 & mg14:::asum(tncTime[,4,], 1)>0)
pClonalSubclonal <- apply(tncTime[,,w],3, function(x) tncLrt(x %*% matrix(c(1,1,1,0,0,0,0,1), ncol=2)))
table(p.adjust(pClonalSubclonal["p",], "bonf")<0.05)
## 
## FALSE  TRUE 
##  1677   710

Mean absolute differences

n <- names(which(p.adjust(pEarlyLate["p",], "bonf")<0.05))
madEarlyLate <- rowSums(abs(t(tncTime[,1,n])/colSums(tncTime[,1,n]) - t(tncTime[,2,n])/colSums(tncTime[,2,n])))/2
n <- names(which(p.adjust(pClonalSubclonal["p",], "bonf")<0.05))
madClonalSubclonal <- rowSums(abs(t(mg14:::asum(tncTime[,1:3,n],2))/colSums(mg14:::asum(tncTime[,1:3,n],2)) - t(tncTime[,4,n])/colSums(tncTime[,4,n])))/2

More signature changes

n <- names(which(sample2icgc=="SA557034"))
e <- nmSolve(tncTime[,,n], P = as.matrix(sbs[,grep("SBS(1|2|13|3|5)$", colnames(sbs))]), maxIter=10000)
e <- cbind(clonal=rowSums(e[,1:3]), subclonal=e[,4])
a <- rbind(`APOBEC`=colSums(e[c(2,5),]), e[-c(2,5),])
apply(t(t(a)/colSums(a))*100,2,mg14:::roundProp)
##        clonal subclonal
## APOBEC     64         7
## SBS1        1         2
## SBS3       31        85
## SBS5        4         6

11.4 Signature analysis

Now assess how the signature attribution changes in samples with measurable spectral shifts. These data were calculated by Clemency Jolly.

sfc <- read.table("../ref/2019-01-03-allSignatureChanges.txt", header=TRUE, sep="\t")

v <- sfc$samplename %in% names(which(p.adjust(pEarlyLate["p",])<0.05))
#mg14:::ggPlot(pmin(100,pmax(0.01,exp(sfc$log2fc_earlyLate[v]*log(2)))),sfc$signature[v], log='y')

11.4.1 Early to late clonal change

11.4.1.1 Figure 4c

#cairo_pdf("sigFcEarlyLate.pdf", 6, 3, pointsize=8)
.par()
par(mar=c(9,3,1,1), bty="n")
s <- names(sort(sapply(split(sfc$log2fc_earlyLate[v]*log(2)/log(10), sfc$signature[v]), median, na.rm=TRUE)))
s <- setdiff(s, c(names(which(table(sfc$signature[v])<10)),"n_unassigned"))
t <- donor2type[sample2donor[as.character(sfc$samplename)[v]]]
f <- function(x) pmax(-2,pmin(2,x*log(2)/log(10)))
x <- jitter(as.numeric(factor(as.character(sfc$signature[v]), levels=s)))
plot(f(sfc$log2fc_earlyLate[v]) ~ x, pch=NA, xaxt='n', xlab="", ylab="fold change", ylim=c(-2.2,2.2), xaxt="n", yaxt="n", lwd=0.5)
#segments(x, y0=f(sfc$lCI_earlyLate[v]), y1=f(sfc$uCI_earlyLate[v]), col='grey')
points(f(sfc$log2fc_earlyLate[v]) ~ x, bg=tissueColors[t], pch=21, col=tissueBorder[t], cex=tissueCex[t])
boxplot(sfc$log2fc_earlyLate[v]*log(2)/log(10) ~factor(as.character(sfc$signature[v]), levels=s), pch=NA, staplewex=0, lty=1, add=TRUE, col=NA, xaxt="n", yaxt="n")
mg14::rotatedLabel(x0=seq_along(s), labels=s)
axis(side=2, at=-2:2, labels=paste0(c("\u2265","","","","\u2264"),10^(-2:2)))
## Warning in axis(side = 2, at = -2:2, labels = paste0(c("≥", "", "", "", : conversion failure on '≥0.01' in 'mbcsToSbcs':
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m <- log10(2:9 %o% 10^(-2:1))
axis(side=2, at=m, tcl=-0.1, labels=rep("", length(m)))
axis(side=1, at=seq_along(s), labels=rep("", length(lengths(s))))
text(0,2.2, "late", pos=4)
text(0,-2.2, "early", pos=4)
abline(h=0, lty=3)

#dev.off()

xlsx output

Figure4c <- createSheet(Figure4, "Figure4c")
addDataFrame(data.frame(sfc[v,c("samplename","signature","log2fc_earlyLate")], tumour_type=t), Figure4c)

Some numbers

t(signif(2^sapply(split(sfc$log2fc_earlyLate[v] , sfc$signature[v])[s], quantile, na.rm=TRUE),2))
##                            0%   25%  50%   75%  100%
## SBS7                   0.0096 0.088 0.16  0.43   2.7
## SBS12                  0.0017 0.058 0.22  0.41   1.6
## SBS4                   0.0610 0.310 0.43  0.72   2.5
## SBS1                   0.0100 0.430 0.73  1.60  54.0
## SBS5                   0.0026 0.490 0.86  1.50 940.0
## SBS17                  0.0082 0.250 0.93  3.50 510.0
## DBS8                   0.6500 0.800 0.96  1.20   3.4
## DBS3                   0.3700 0.810 0.98  1.30   1.5
## DBS2                   0.0750 0.720 1.00  1.30  15.0
## ID1                    0.0450 0.620 1.00  1.90  22.0
## ID13                   0.3100 0.800 1.10  1.50   4.6
## DBS11                  0.0780 0.780 1.10  1.70   9.1
## ID2                    0.0610 0.700 1.10  2.00  22.0
## DBS7                   0.4000 0.820 1.10  1.60   7.0
## SBS18                  0.0074 0.770 1.10  2.10   5.8
## DBS6                   0.3000 0.880 1.20  1.70   5.4
## DBS1                   0.1800 0.790 1.20  1.90   3.7
## DBS9                   0.2700 0.800 1.20  1.80  12.0
## DBS4                   0.1600 0.820 1.20  1.70  11.0
## ID8                    0.2100 0.850 1.20  2.10  32.0
## SBS37                  0.6700 0.810 1.30  4.00 170.0
## SBS6.14.15.20.21.26.44 0.4300 1.000 1.30  1.80   4.5
## SBS40                  0.1600 0.880 1.40  2.20  44.0
## SBS3                   0.3500 0.960 1.50  2.00  26.0
## SBS29                  0.4100 0.840 1.50  1.80   4.9
## DBS5                   0.3900 0.890 1.50  3.70  33.0
## SBS41                  0.0100 0.930 1.80  1.90  11.0
## SBS2.13                0.0190 0.820 2.00  3.60  86.0
## SBS38                  0.6300 1.800 3.60 11.00  31.0

11.4.2 Clonal to subclonal changes

11.4.2.1 Figure 4d

w <- sfc$samplename %in% names(which(p.adjust(pClonalSubclonal["p",])<0.05))
#cairo_pdf("sigFcClonalSubclonal.pdf", 6, 3, pointsize=8)
.par()
par(mar=c(9,3,1,1), bty="n")
s <- names(sort(sapply(split(sfc$log2fc_clonalSubclonal[w]*log(2)/log(10), sfc$signature[w]), median, na.rm=TRUE)))
s <- setdiff(s, c(names(which(table(sfc$signature[w])<10)),"n_unassigned"))
t <- donor2type[sample2donor[as.character(sfc$samplename)[w]]]
f <- function(x) pmax(-2,pmin(2,x*log(2)/log(10)))
x <- jitter(as.numeric(factor(as.character(sfc$signature[w]), levels=s)))
plot(f(sfc$log2fc_clonalSubclonal[w]) ~ x, pch=NA, xaxt='n', xlab="", ylab="fold change", ylim=c(-2.2,2.2), xaxt="n", yaxt="n", lwd=0.5)
#segments(x, y0=f(sfc$lCI_clonalSubclonal[v]), y1=f(sfc$uCI_clonalSubclonal[v]), col='grey')
points(f(sfc$log2fc_clonalSubclonal[w]) ~ x, bg=tissueColors[t], pch=21, col=tissueBorder[t], cex=tissueCex[t])
boxplot(f(sfc$log2fc_clonalSubclonal[w]) ~factor(as.character(sfc$signature[w]), levels=s), pch=NA, staplewex=0, lty=1, add=TRUE, col=NA, xaxt="n", yaxt="n")
mg14::rotatedLabel(x0=seq_along(s), labels=s)
axis(side=2, at=-2:2, labels=paste0(c("\u2265","","","","\u2264"),10^(-2:2)))
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m <- log10(2:9 %o% 10^(-2:1))
axis(side=2, at=m, tcl=-0.1, labels=rep("", length(m)))
axis(side=1, at=seq_along(s), labels=rep("", length(lengths(s))))
text(0,2.2, "subclonal", pos=4)
text(0,-2.2, "clonal", pos=4)
abline(h=0, lty=3)

#dev.off()

xlsx output

Figure4d <- createSheet(Figure4, "Figure4d")
addDataFrame(data.frame(sfc[w,c("samplename","signature","log2fc_clonalSubclonal")], tumour_type=t), Figure4d)

Some numbers

t(signif(2^sapply(split(sfc$log2fc_clonalSubclonal[w] , sfc$signature[w])[s], quantile, na.rm=TRUE),2))
##                             0%   25%    50%    75%   100%
## SBS9                   0.00083 0.019  0.053   0.43   2.20
## SBS7                   0.00660 0.090  0.180   0.24   0.65
## SBS12                  0.00190 0.090  0.270   0.44   1.60
## ID2                    0.00069 0.200  0.480   1.30 120.00
## ID1                    0.00830 0.220  0.550   1.50 240.00
## SBS17                  0.00500 0.270  0.570   1.80  59.00
## SBS4                   0.00110 0.410  0.580   0.95   4.90
## SBS1                   0.00410 0.380  0.640   1.20  57.00
## SBS16                  0.00190 0.013  0.730   1.10   8.80
## DBS8                   0.34000 0.740  0.850   1.10   4.10
## SBS5                   0.00200 0.400  0.860   1.50 370.00
## DBS10                  0.73000 0.930  0.950   0.99   2.50
## SBS30                  0.18000 0.510  0.960   2.80 380.00
## ID13                   0.38000 0.760  0.990   1.50  12.00
## SBS3                   0.03900 0.650  1.000   1.60   8.70
## DBS2                   0.20000 0.730  1.000   1.60   8.70
## SBS41                  0.00280 0.220  1.100   1.40  17.00
## SBS28                  0.22000 0.660  1.100   1.50   4.60
## DBS4                   0.20000 0.720  1.100   1.80  11.00
## DBS6                   0.26000 0.780  1.100   1.80   9.10
## DBS11                  0.25000 0.790  1.100   1.90  10.00
## SBS22                  0.12000 0.500  1.200   2.10  18.00
## DBS9                   0.19000 0.820  1.200   1.70  11.00
## DBS7                   0.33000 0.930  1.200   2.00   9.20
## DBS3                   0.15000 0.960  1.200   1.60   6.20
## SBS18                  0.00470 0.740  1.200   2.00  15.00
## ID8                    0.04700 0.630  1.300   2.50  16.00
## SBS40                  0.07900 0.750  1.400   2.20  24.00
## SBS29                  0.01300 1.000  1.400   2.40   7.50
## DBS5                   0.28000 0.700  1.600   2.50  14.00
## SBS2.13                0.03400 0.790  1.600   2.60 170.00
## DBS1                   0.36000 0.930  1.600   2.50   8.20
## SBS6.14.15.20.21.26.44 0.23000 1.200  1.800   3.00  72.00
## SBS37                  0.21000 1.600 29.000 350.00 540.00

Legend for figure

#pdf("legend.pdf", 2,4)
.par()
par(mar=c(0,0,0,0), bty="n")
plot(NA,NA, xlim=c(-1,1), ylim=c(-1,1), xaxt="n",yaxt="n", xlab='', ylab="")
l <- as.character(sort(unique(donor2type[sample2donor[as.character(sfc$samplename)[w | v]]])))
n <- unique(c(names(which(p.adjust(pClonalSubclonal["p",])<0.05)),names(which(p.adjust(pEarlyLate["p",])<0.05))))
m <- unique(c(names(pClonalSubclonal["p",]),names(pEarlyLate["p",])))
s <- table(donor2type[sample2donor[n]])[l]
t <- table(donor2type[sample2donor[m]])[l]
#l <- l[order(-s/t)]
legend("top", legend=paste0(l, " (",s[l],"/",t[l],")"), pt.bg=tissueColors[l], pch=21, col=tissueBorder[l], pt.cex=tissueCex[l], bty="n")

dev.off()
## null device 
##           1

12 Outputs

12.1 Figure data

Save output underlying figures.

saveWorkbook(Figure1,'Figure1.xlsx')
saveWorkbook(Figure2,'Figure2.xlsx')
saveWorkbook(Figure4,'Figure4.xlsx')
saveWorkbook(Figure5,'Figure5.xlsx')
saveWorkbook(ExtendedDataFigure3,'ExtendedDataFigure3.xlsx')
saveWorkbook(ExtendedDataFigure6,'ExtendedDataFigure6.xlsx')
saveWorkbook(ExtendedDataFigure8,'ExtendedDataFigure8.xlsx')
saveWorkbook(ExtendedDataFigure9,'ExtendedDataFigure9.xlsx')

12.2 Real time WGD & MRCA

Other working group output, to be released on synapse https://www.synapse.org/#!Synapse:syn14193595. These data may be more useful than the specific subsets underlying each published figure.

n <- names(finalSnv)
wgdMrcaTimingData <- data.frame(
        uuid=n,
        icgc_sample_id=sample2icgc[n], 
        icgc_donor_id=sample2donor[n], 
        tissue=donor2type[sample2donor[n]], 
        WGD=isWgd, 
        ploidy=finalPloidy,
        eff_ploidy=effGenome,
        purity=finalPurity,
        age=round(age[sample2donor[n]]),
        n_snv_mnv=sapply(finalSnv, nrow),
        CpG_TpG_trunk_pwradj=round(branchDeam[,2],2),
        CpG_TpG_subclonal_branch_pwradj=round(branchDeam[,1],2),
        CpG_TpG_subclonal_linear_pwradj=round(branchDeamLinear[,1],2),
        TiN = TiN[sample2donor[n]],
        remove = n %in% remove,
        accel = ifelse(n %in% remove,NA,guessAccel[as.character(donor2type[sample2donor[n]])]), 
        row.names=n)

t <- as.data.frame(round(Reduce("rbind", wgdTimeAbsType),2))
colnames(t) <- c("time", "time.lo","time.up")
w <- data.frame(row.names=rownames(t), t, `CpG_TpG_total`=nDeam[rownames(t)])
colnames(w) <- sub("lo", "10%", sub("up","90%", colnames(w)))

t <- cbind(branching=as.data.frame(round(Reduce("rbind", subclonesTimeAbsType),2)), linear=as.data.frame(round(Reduce("rbind", subclonesTimeAbsTypeLinear),2)))
colnames(t) <- sub("\\.hat","", colnames(t))

wgdMrcaTimingData <- cbind(wgdMrcaTimingData, 
        WGD=w[rownames(wgdMrcaTimingData),],
        MRCA.time=t[rownames(wgdMrcaTimingData),]
)

write.table(wgdMrcaTimingData, file=paste0(Sys.Date(),"-wgdMrcaTiming.txt"), sep="\t", quote=FALSE, row.names=FALSE)

12.3 All segments, MutationTime.R raw values

t <- do.call("rbind", mclapply(finalBB, function(bb) as.data.frame(bb[,c(1:6,38:47)])))
n <- rownames(t) 
t <- as.data.frame(lapply(t, function(x) if(class(x)=="numeric") round(x,3) else x)) 
t$sample <- sub("\\..+","",n)
write.table(t, file=paste0(Sys.Date(),"-allSegmentsTimeRaw.txt"), quote=FALSE, sep="\t")

12.4 Drivers

t <- as.data.frame(finalDriversAnnotated)[c(1,2,6,7,9,10,11,12,13,14,31:44)]
t <- as.data.frame(lapply(t, function(x) if(class(x)=="numeric") round(x,3) else x));
write.table(t, file=paste0(Sys.Date(),"-driversTiming.txt"), quote=FALSE, sep="\t")

13 Session

13.1 Commit

cat(system("git log -n1", intern=TRUE), sep="\n")
## commit 612fdd0d37a629e5cdc4a9b6686f30a0984a6202
## Author: Moritz Gerstung <moritz.gerstung@ebi.ac.uk>
## Date:   Tue Jan 7 09:54:59 2020 +0000
## 
##     Another bug fix

13.2 Objects

l <- ls()
data.frame(variable=l, Reduce("rbind",lapply(l, function(x) data.frame(class=class(get(x)), size=format(object.size(get(x)), units="auto")))))
##                        variable        class      size
## 1                             a       matrix 944 bytes
## 2                            ab        array    9.1 Kb
## 3                         accel      numeric 640 bytes
## 4                   accelRelWgd         list     83 Kb
## 5                 addAssignment     function   12.1 Kb
## 6                     addDriver     function   27.1 Kb
## 7                addFinalDriver     function   16.7 Kb
## 8                      addMutCn     function   12.5 Kb
## 9                        addTNC     function   18.8 Kb
## 10                          age      numeric  202.2 Kb
## 11       aggregatePerChromosome     function   32.4 Kb
## 12                    allChrAgg        array    2.8 Mb
## 13             allChrCancerHist        array     79 Kb
## 14                    allGender   data.frame    1.3 Mb
## 15              applyPigeonHole     function   16.8 Kb
## 16                         asum     function   18.4 Kb
## 17                           at     function   59.7 Kb
## 18            averageEvenPloidy     function    8.8 Kb
## 19                   averageHom     function   24.2 Kb
## 20                averagePloidy     function   28.9 Kb
## 21                   avgWeights     function   31.5 Kb
## 22                            b       matrix 984 bytes
## 23                       b_mrca      numeric 288 bytes
## 24                    b_primary      numeric 288 bytes
## 25                    b_relapse      numeric 288 bytes
## 26                     basePath    character 168 bytes
## 27                           bb      GRanges   12.6 Kb
## 28                      bbFiles    character  48 bytes
## 29                       bbPath    character 232 bytes
## 30                     bbToTime     function   72.8 Kb
## 31                   betaFromCi     function  123.9 Kb
## 32                   branchDeam       matrix    326 Kb
## 33             branchDeamLinear       matrix    326 Kb
## 34                branchLengths     function     19 Kb
## 35                          bwd      numeric  56 bytes
## 36                            c    character    5.3 Kb
## 37                  CANCERGENES    character   52.4 Kb
## 38                           cc         list   43.9 Kb
## 39                    chrOffset      numeric    6.8 Kb
## 40                           ci       matrix      1 Kb
## 41            classifyMutations     function   58.8 Kb
## 42                     classWgd     function    1.7 Kb
## 43                 clinicalData   data.frame  949.7 Kb
## 44                     clusters   data.frame      1 Kb
## 45               clustersFromBB     function   12.8 Kb
## 46                           cn   data.frame  132.3 Mb
## 47                       cnPath    character 232 bytes
## 48                     cnStates         list    2.9 Kb
## 49                    cnWeights     function     27 Kb
## 50                          col    character 736 bytes
## 51                    colon_sbs   data.frame  105.1 Kb
## 52                      colTime    character      1 Kb
## 53                 computeMutCn     function    2.7 Mb
## 54      computeSubclonesTimeAbs     function  284.4 Kb
## 55          computeWgdParamDeam     function   41.1 Kb
## 56       consensusClustersToOld     function    5.6 Kb
## 57                   cosineDist     function   24.6 Kb
## 58                       cpgtpg      logical  511.4 Kb
## 59                           ct      integer  250.8 Kb
## 60                            d       matrix     88 Kb
## 61                           d0      numeric    3.2 Kb
## 62                           d1      numeric    3.2 Kb
## 63                          d50      integer  64 bytes
## 64                         data         list    1.4 Mb
## 65                   dbetabinom     function     29 Kb
## 66             dClonalSubclonal      numeric   70.9 Kb
## 67                   dEarlyLate      numeric   64.8 Kb
## 68              defineMcnStates     function    1.3 Mb
## 69                           df   data.frame  243.6 Kb
## 70                  distAsRange     function   17.2 Kb
## 71                 donor2sample         list   26.1 Kb
## 72                   donor2type       factor    211 Kb
## 73                  doubleGains   data.frame  295.4 Kb
## 74        doubleGainsAggregated   data.frame   41.8 Kb
## 75                      dpFiles    character  325.6 Kb
## 76                       dpPath    character 168 bytes
## 77                 dtrbetabinom     function   42.2 Kb
## 78                     dtrbinom     function    3.1 Kb
## 79                     dumpfile    character 136 bytes
## 80                            e       matrix    1.1 Kb
## 81                    effGenome      numeric    304 Kb
## 82          ExtendedDataFigure3      jobjRef 944 bytes
## 83         ExtendedDataFigure3b      jobjRef 944 bytes
## 84         ExtendedDataFigure3d      jobjRef 944 bytes
## 85          ExtendedDataFigure6      jobjRef 944 bytes
## 86         ExtendedDataFigure6a      jobjRef 944 bytes
## 87         ExtendedDataFigure6b      jobjRef 944 bytes
## 88          ExtendedDataFigure8      jobjRef 944 bytes
## 89         ExtendedDataFigure8a      jobjRef 944 bytes
## 90         ExtendedDataFigure8b      jobjRef 944 bytes
## 91         ExtendedDataFigure8c      jobjRef 944 bytes
## 92         ExtendedDataFigure8d      jobjRef 944 bytes
## 93         ExtendedDataFigure8e      jobjRef 944 bytes
## 94         ExtendedDataFigure8f      jobjRef 944 bytes
## 95         ExtendedDataFigure8g      jobjRef 944 bytes
## 96         ExtendedDataFigure8h      jobjRef 944 bytes
## 97          ExtendedDataFigure9      jobjRef 944 bytes
## 98         ExtendedDataFigure9a      jobjRef 944 bytes
## 99         ExtendedDataFigure9b      jobjRef 944 bytes
## 100        ExtendedDataFigure9c      jobjRef 944 bytes
## 101        ExtendedDataFigure9d      jobjRef 944 bytes
## 102        ExtendedDataFigure9e      jobjRef 944 bytes
## 103        ExtendedDataFigure9f      jobjRef 944 bytes
## 104        ExtendedDataFigure9g      jobjRef 944 bytes
## 105                           f     function   15.1 Kb
## 106                     Figure1      jobjRef 944 bytes
## 107                    Figure1f      jobjRef 944 bytes
## 108                    Figure1g      jobjRef 944 bytes
## 109                    Figure1h      jobjRef 944 bytes
## 110                     Figure2      jobjRef 944 bytes
## 111                    Figure2a      jobjRef 944 bytes
## 112                   Figure2a2      jobjRef 944 bytes
## 113                   Figure2a3      jobjRef 944 bytes
## 114                    Figure2d      jobjRef 944 bytes
## 115                     Figure4      jobjRef 944 bytes
## 116                    Figure4a      jobjRef 944 bytes
## 117                    Figure4b      jobjRef 944 bytes
## 118                    Figure4c      jobjRef 944 bytes
## 119                    Figure4d      jobjRef 944 bytes
## 120                     Figure5      jobjRef 944 bytes
## 121                    Figure5b      jobjRef 944 bytes
## 122                    Figure5c      jobjRef 944 bytes
## 123                     finalBB         list    3.8 Gb
## 124                 finalBBGray         list   73.5 Mb
## 125               finalClusters         list      3 Mb
## 126           finalClustersGray         list   84.7 Kb
## 127                   finalData   data.frame     11 Mb
## 128                finalDrivers      VRanges    1.5 Mb
## 129       finalDriversAnnotated      VRanges    2.2 Mb
## 130              finalGenotypes        array  156.2 Mb
## 131             finalGenotypesP        array  104.3 Mb
## 132             finalGenotypesQ        array   21.1 Mb
## 133                    finalHom      numeric    304 Kb
## 134                  finalIndel         list      2 Gb
## 135              finalIndelGray         list  673.6 Mb
## 136                 finalPloidy      numeric    304 Kb
## 137                  finalPower         list  622.3 Kb
## 138                 finalPurity      numeric    304 Kb
## 139             finalPurityGray      numeric    8.4 Kb
## 140                    finalSnv         list   21.8 Gb
## 141                finalSnvGray         list    1.7 Gb
## 142                     finalSv         list    3.2 Gb
## 143             findMainCluster     function  117.5 Kb
## 144                  first_time      logical  56 bytes
## 145                         fit      stanfit     63 Mb
## 146                   flattenBB     function   23.5 Kb
## 147                          fm      numeric    2.7 Kb
## 148                         fmq       matrix    3.4 Kb
## 149                         foo   data.frame    3.1 Mb
## 150           fracGenomeWgdComp       matrix  500.3 Kb
## 151 fractionGenomeWgdCompatible     function  185.5 Kb
## 152                           g       matrix   63.1 Kb
## 153                 getAltCount     function  168.4 Kb
## 154                 getGenotype     function   18.6 Kb
## 155          getMutationCluster     function    7.2 Kb
## 156              getTumorCounts     function    7.4 Kb
## 157               getTumorDepth     function   81.1 Kb
## 158                    grayList      logical   10.9 Kb
## 159                          gt       matrix  205.2 Kb
## 160                         gtu       matrix    151 Kb
## 161                          gu       matrix   37.1 Kb
## 162                  guessAccel    character    3.1 Kb
## 163                           h    histogram    2.3 Kb
## 164                          hh       matrix    3.9 Kb
## 165                          hi      integer  64 bytes
## 166                    histBeta     function  166.9 Kb
## 167                    hsc_data   data.frame   72.4 Mb
## 168                           i      integer  56 bytes
## 169                           I       matrix    1.2 Mb
## 170                   is_cpgtpg      logical  288.7 Kb
## 171               isDeamination     function     17 Kb
## 172           isDeaminationNoUV     function   17.1 Kb
## 173                       isWgd      logical  293.2 Kb
## 174                           j      numeric 544 bytes
## 175                           J       matrix    1.3 Mb
## 176                           l    character   23.8 Kb
## 177                     lineCol    character    5.2 Kb
## 178                          lo      integer  64 bytes
## 179              loadAssignment     function    6.9 Kb
## 180                      loadBB     function    8.5 Kb
## 181                loadClusters     function    9.2 Kb
## 182                      loadCn     function    5.3 Kb
## 183       loadConsensusClusters     function    9.2 Kb
## 184            loadConsensusCNA     function   55.7 Kb
## 185               loadPositions     function    9.5 Kb
## 186                     loadVcf     function   27.6 Kb
## 187                           m    character    273 Kb
## 188                          m0      numeric   81.9 Kb
## 189                          ma      numeric    3.3 Kb
## 190          madClonalSubclonal      numeric   77.9 Kb
## 191                madEarlyLate      numeric   57.6 Kb
## 192                   makeTitle     function   19.8 Kb
## 193                matchDrivers     function   16.5 Kb
## 194                   mcnHeader     function   13.3 Kb
## 195               mergeClusters     function   23.4 Kb
## 196  mergeClustersByMutreadDiff     function   71.1 Kb
## 197                      my_png     function   26.9 Kb
## 198                           n    character  282.2 Kb
## 199                    n_cpgtpg      numeric   10.1 Kb
## 200                       na.rm     function    1.7 Kb
## 201                     nClones      integer  293.2 Kb
## 202                       nDeam      integer     79 Kb
## 203                     nDeam22      numeric   81.9 Kb
## 204                     nmSolve     function  136.8 Kb
## 205         normal_colon_cpgtpg      numeric 440 bytes
## 206               normal_cpgtpg       matrix    1.1 Kb
## 207   normal_endometrium_cpgtpg      numeric 440 bytes
## 208           normal_hsc_cpgtpg      numeric 440 bytes
## 209          normal_skin_cpgtpg      numeric  56 bytes
## 210                        nSub      integer  293.2 Kb
## 211                  nSubclones      integer    2.8 Kb
## 212                        nWgd      integer    2.2 Kb
## 213                           o      integer 176 bytes
## 214                           p         list  164.4 Kb
## 215                 parseRegion     function   10.8 Kb
## 216                  pbetabinom     function     29 Kb
## 217            pClonalSubclonal       matrix  299.3 Kb
## 218                  pEarlyLate       matrix  232.4 Kb
## 219                 pGainToTime     function   26.3 Kb
## 220                          pi       matrix 248 bytes
## 221                    piToTime     function   97.1 Kb
## 222                      plotBB     function    553 Kb
## 223                   plotPoset     function    9.2 Kb
## 224                  plotSample     function  609.1 Kb
## 225                      plotSv     function  354.9 Kb
## 226                  plotTiming     function  517.8 Kb
## 227                     plotVcf     function    342 Kb
## 228                   posetDist     function   14.9 Kb
## 229              posteriorMutCN     function   18.1 Kb
## 230                       power     function    6.7 Kb
## 231             predictRealTime     function    8.4 Kb
## 232                        prgn    character 792 bytes
## 233                probGenotype     function   17.8 Kb
## 234            probGenotypeTail     function   16.6 Kb
## 235                ptrbetabinom     function   39.3 Kb
## 236                          pu       matrix   44.9 Kb
## 237                      purity      numeric  56 bytes
## 238                purityPloidy   data.frame  370.7 Kb
## 239                           q       matrix    4.6 Kb
## 240                          q1      numeric    304 Kb
## 241                          q5      numeric    304 Kb
## 242                qAccelRelWgd       matrix    3.7 Kb
## 243                     qPanCan      numeric 584 bytes
## 244                   qRateDeam       matrix    4.6 Kb
## 245                   qSubclone        array   11.6 Kb
## 246             qSubcloneLinear        array   11.6 Kb
## 247                        qWgd        array    9.2 Kb
## 248                           r     function    1.6 Kb
## 249                    rateDeam         list  311.4 Kb
## 250                    reduceBB     function   30.1 Kb
## 251      reduceToCoverRelations     function     43 Kb
## 252                     refFile    character 136 bytes
## 253                  refLengths      GRanges   23.1 Kb
## 254                     relapse   data.frame    8.8 Kb
## 255                      remove    character   75.5 Kb
## 256           removeSuperclones     function   24.2 Kb
## 257                         rho      numeric  56 bytes
## 258                           s        table    3.4 Kb
## 259                sample2donor    character  481.1 Kb
## 260                 sample2icgc    character  506.8 Kb
## 261                         sbs   data.frame   61.1 Kb
## 262             selectedSamples      logical   10.9 Kb
## 263                        set1    character 680 bytes
## 264                         sfc   data.frame    2.8 Mb
## 265                      sigCol       matrix    1.9 Kb
## 266           simulateMutations     function  407.3 Kb
## 267                specimenData   data.frame    2.6 Mb
## 268                   stackTime     function     31 Kb
## 269            subclonesTimeAbs         list  708.4 Kb
## 270      subclonesTimeAbsLinear         list  708.4 Kb
## 271        subclonesTimeAbsType         list  277.5 Kb
## 272  subclonesTimeAbsTypeLinear         list  277.5 Kb
## 273                           t   data.frame    1.9 Mb
## 274                      t_mrca      numeric 288 bytes
## 275                   t_primary      numeric 288 bytes
## 276                   t_relapse      numeric 288 bytes
## 277                       T.i.F       matrix  294.3 Kb
## 278                          t0      numeric   81.9 Kb
## 279                          t2      numeric  56 bytes
## 280                          t3      numeric  56 bytes
## 281                         tab   data.frame    4.4 Kb
## 282                  testDriver     function    5.4 Kb
## 283                   testIndel     function    5.4 Kb
## 284                  timeToBeta     function   17.9 Kb
## 285                 timing_data       matrix    3.3 Mb
## 286                 timingClass       factor    294 Kb
## 287                  timingInfo   data.frame  578.4 Kb
## 288                         TiN      numeric  202.2 Kb
## 289                tissueBorder    character    3.4 Kb
## 290                   tissueCex      numeric    3.3 Kb
## 291                tissueColors    character    5.2 Kb
## 292                 tissueLines    character    5.2 Kb
## 293                   tissueLty      numeric    3.3 Kb
## 294                         tnc DNAStringSet    2.9 Mb
## 295                      tncLrt     function   80.8 Kb
## 296                     tncTime        array    4.4 Mb
## 297             tncToPyrimidine     function  124.9 Kb
## 298                     toGraph     function   11.4 Kb
## 299                         tpy      numeric  56 bytes
## 300               tryExceptNull     function    2.1 Kb
## 301                          tt    character 344 bytes
## 302                         tt0       matrix    326 Kb
## 303                         ttl     function   38.5 Kb
## 304                      typeNa    character 496 bytes
## 305              typesSubclones    character    2.5 Kb
## 306                           u    character  204.3 Kb
## 307               uniqueSamples      logical   10.9 Kb
## 308                           v      logical   99.3 Kb
## 309                         vcf CollapsedVCF   52.8 Mb
## 310                    vcfIndel CollapsedVCF   45.5 Mb
## 311                     vcfPath    character 152 bytes
## 312                        void      logical   86.5 Kb
## 313                          vv        table    2.9 Kb
## 314                           w   data.frame   75.8 Kb
## 315                         w22      numeric   81.9 Kb
## 316                 wccClusters         list      3 Mb
## 317                   wccPurity      numeric   21.8 Kb
## 318                    wccTable   data.frame  592.8 Kb
## 319          wemeClustersMerged         list    3.4 Mb
## 320               wgdCancerHist       matrix    6.1 Kb
## 321           wgdMrcaTimingData   data.frame    1.4 Mb
## 322                wgdParamDeam         list   50.8 Mb
## 323                     wgdPoss      logical  293.2 Kb
## 324                     wgdStar       factor  293.8 Kb
## 325                     wgdStat       factor  293.8 Kb
## 326                     wgdTest     function   14.9 Kb
## 327                  wgdTimeAbs         list  197.5 Kb
## 328              wgdTimeAbsType         list   92.6 Kb
## 329              wgdTimeDeamAcc        array   12.4 Mb
## 330                   whiteList      logical   10.9 Kb
## 331                    wnmSolve     function   41.6 Kb
## 332                          wu      logical   30.2 Kb
## 333                          ww      integer  56 bytes
## 334                           x    character 112 bytes
## 335                          x0      numeric 280 bytes
## 336                          xx      numeric    1.8 Kb
## 337                           y      numeric    2.3 Kb
## 338                          y0      numeric    2.3 Kb
## 339                          y1      numeric    2.3 Kb
## 340                          yy      numeric    1.8 Kb

13.3 Packages

sessionInfo()
## R version 3.5.1 (2018-07-02)
## Platform: x86_64-redhat-linux-gnu (64-bit)
## Running under: Red Hat Enterprise Linux
## 
## Matrix products: default
## BLAS/LAPACK: /usr/lib64/R/lib/libRblas.so
## 
## locale:
##  [1] LC_CTYPE=en_GB.UTF-8          LC_NUMERIC=C                  LC_TIME=en_GB.UTF-8          
##  [4] LC_COLLATE=en_GB.UTF-8        LC_MONETARY=en_GB.UTF-8       LC_MESSAGES=en_GB.UTF-8      
##  [7] LC_PAPER=en_GB.UTF-8          LC_NAME=en_GB.UTF-8           LC_ADDRESS=en_GB.UTF-8       
## [10] LC_TELEPHONE=en_GB.UTF-8      LC_MEASUREMENT=en_GB.UTF-8    LC_IDENTIFICATION=en_GB.UTF-8
## 
## attached base packages:
##  [1] splines   stats4    parallel  stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] rstan_2.17.2               StanHeaders_2.17.2         ggplot2_3.2.1              xlsx_0.6.1                
##  [5] VGAM_1.1-1                 VariantAnnotation_1.20.3   SummarizedExperiment_1.4.0 Biobase_2.34.0            
##  [9] Rsamtools_1.26.2           Biostrings_2.42.1          XVector_0.14.1             GenomicRanges_1.26.4      
## [13] GenomeInfoDb_1.10.3        IRanges_2.8.2              S4Vectors_0.12.2           BiocGenerics_0.20.0       
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## [13] digest_0.6.20            RColorBrewer_1.1-2       colorspace_1.4-1         htmltools_0.3.6         
## [17] Matrix_1.2-14            XML_3.98-1.20            pkgconfig_2.0.2          biomaRt_2.30.0          
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## [25] openxlsx_4.1.0.1         rio_0.5.16               BiocParallel_1.8.2       tibble_2.1.3            
## [29] car_3.0-3                withr_2.1.2              GenomicFeatures_1.26.4   lazyeval_0.2.2          
## [33] readxl_1.3.1             magrittr_1.5             crayon_1.3.4             memoise_1.1.0           
## [37] evaluate_0.14            forcats_0.4.0            foreign_0.8-70           beeswarm_0.2.3          
## [41] tools_3.5.1              data.table_1.12.2        hms_0.5.0                stringr_1.4.0           
## [45] munsell_0.5.0            zip_2.0.3                AnnotationDbi_1.36.2     compiler_3.5.1          
## [49] mg14_0.0.5               rlang_0.4.0              grid_3.5.1               RCurl_1.95-4.12         
## [53] bitops_1.0-6             rmarkdown_1.14           gtable_0.3.0             codetools_0.2-15        
## [57] inline_0.3.15            abind_1.4-5              DBI_1.0.0                curl_4.0                
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## [69] Rcpp_1.0.2               vctrs_0.2.0              xfun_0.8
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## ─ Session info ───────────────────────────────────────────────────────────────────────────────────────────────────────
##  setting  value                       
##  version  R version 3.5.1 (2018-07-02)
##  os       Red Hat Enterprise Linux    
##  system   x86_64, linux-gnu           
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##  date     2020-01-07                  
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## [1] /homes/mg14/R/x86_64-redhat-linux-gnu-library/3.5
## [2] /usr/lib64/R/library
## [3] /usr/share/R/library

14 Other code

All code is available at github.com/gerstung-lab/PCAWG-11

14.1 MutationTime.R

See https://github.com/gerstung-lab/MutationTime.R

#' # Calculation of mutation copy numbers and timing parameters
#' Minimal example
#' source("/Users/mg14/Projects/PCAWG-11/code/MutationTime.R")
#' vcf <- readVcf("final/final_consensus_12oct_passonly/snv_mnv/0040b1b6-b07a-4b6e-90ef-133523eaf412.consensus.20160830.somatic.snv_mnv.vcf.gz",genome="GRCh37")
#' bb <- loadBB("dp/20161213_vanloo_wedge_consSNV_prelimConsCNAallStar/4_copynumber/0040b1b6-b07a-4b6e-90ef-133523eaf412_segments.txt.gz")
#' clusters = read.table("dp/20161213_vanloo_wedge_consSNV_prelimConsCNAallStar/2_subclones/0040b1b6-b07a-4b6e-90ef-133523eaf412_subclonal_structure.txt.gz", header=TRUE, sep="\t")
#' purityPloidy <- read.table("dp/20161213_vanloo_wedge_consSNV_prelimConsCNAallStar/1_purity_ploidy/purity_ploidy.txt, header=TRUE, sep="\t")
#' purity <- purityPloidy[2,2]
#' MCN <- computeMutCn(vcf[1:1000], bb, clusters, purity)
#' # Check output
#' # Mutation Annotation
#' head(MCN$D)
#' # Classify as basic clonal states
#' table(classifyMutations(MCN$D))
#' # Timing parameters
#' MCN$P[[1]]
#' # Extract timing of segments
#' bb$timing_param <- MCN$P
#' bbToTime(bb)
#' PRE: Purity must be equal to the main clone, otherwise spurious results can be generated
#' PRE: CNV segments don't have to overlap, otherwise an error is generated: "Error in if (!mixFlag[j]) { : missing value where TRUE/FALSE needed"

require(VariantAnnotation)
require(VGAM)



#' Extract tumour depth
#' @param vcf 
#' @return 
#' 
#' @author mg14
#' @export
getTumorDepth <- function(vcf){
    if("t_alt_count" %in% colnames(info(vcf))){ ## consensus data, snv and indel
        info(vcf)$t_alt_count + info(vcf)$t_ref_count
    }else{ ## older data
        if("FAZ" %in% rownames(geno(header(vcf)))){
            rowSums(getTumorCounts(vcf))
        }else{
            geno(vcf)$DEP[,2]
        }
    }
}


#' Get alt alleles counts 
#' @param vcf 
#' @return 
#' 
#' @author mg14
#' @export
getAltCount <- function(vcf){
    if("t_alt_count" %in% colnames(info(vcf))){ ## consensus data, snv and indel
        info(vcf)$t_alt_count
    }else{ ## older formats
        if("FAZ" %in% rownames(geno(header(vcf)))){ ## ie subs
            c <- getTumorCounts(vcf)
            t <- c[,1:4] + c[,5:8]
            colnames(t) <- substring(colnames(t),2,2)
            a <- as.character(unlist(alt(vcf)))
            a[!a%in%c('A','T','C','G')] <- NA
            sapply(seq_along(a), function(i) if(is.na(a[i])) NA else t[i, a[i]])
        }
        else{ ## ie indel
            #(geno(vcf)$PP + geno(vcf)$NP + geno(vcf)$PB + geno(vcf)$NB)[,"TUMOUR"]
            geno(vcf)$MTR[,2]
        }
    }
}

dtrbinom <- function(x, size, prob, xmin=0) dbinom(x,size,prob) / pbinom(xmin-1, size, prob, lower.tail=FALSE)
pbetabinom <- function(x, size, prob, rho){
    if(rho!=0)
        VGAM::pbetabinom(x, size, prob, rho)
    else
        pbinom(x, size, prob)
}
dbetabinom <- function(x, size, prob, rho){
    if(rho!=0)
        VGAM::dbetabinom(x, size, prob, rho)
    else
        dbinom(x, size, prob)
}
dtrbetabinom <- function(x, size, prob, rho, xmin=0) {y <- dbetabinom(x,size,prob,rho) / (1-pbetabinom(xmin-1, size, prob, rho))
    y[x<xmin] <- 0
    return(y)}
ptrbetabinom <- function(x, size, prob, rho, xmin=0) {
    pmin <- pbetabinom(xmin-1, size, prob, rho)
    pmax(0,(pbetabinom(x,size,prob,rho) - pmin) / (1-pmin))}


mergeClusters <- function(clusters, deltaFreq=0.05){
    if(nrow(clusters) <= 1) return(clusters)
    h <- hclust(dist(clusters$proportion))
    ct <- cutree(h, h=deltaFreq)
    cp <- as.matrix(cophenetic(h))
    Reduce("rbind",lapply(unique(ct), function(i) {
                        n_ssms <- sum(clusters$n_ssms[ct==i])
                        w <- max(cp[ct==i,ct==i])
                        data.frame(new.cluster=i, n_ssms=n_ssms, proportion=sum(clusters$proportion[ct==i]*clusters$n_ssms[ct==i])/n_ssms, width=w)
                    }
            ))
}

#' Compute possible Mutation copy number states
#' @param bb Copy number with consensus annotation meta data
#' @param clusters 
#' @param purity 
#' @param gender 
#' @param isWgd 
#' @return list of length nrow(bb), can be added to mcols(bb)
#' 
#' @author mg14
#' @export
defineMcnStates <- function(bb, clusters, purity, gender='female', isWgd= FALSE){
    P <- vector(mode='list', length(bb))
    uniqueBB <- unique(bb)
    overlaps <- findOverlaps(uniqueBB, bb)
    
    majorCN <- split(bb$major_cn[subjectHits(overlaps)], queryHits(overlaps))
    m <- bb$minor_cn #hack: minor_cn > 0 in male samples - Battenberg bug?
    if(gender=='male')
        m[as.character(seqnames(bb)) %in% c('X','Y')] <- 0
    minorCN <- split(m[subjectHits(overlaps)], queryHits(overlaps)) 
    h <- selectHits(overlaps, "first")
    H <- selectHits(overlaps, "last")
    
    cnNormal <- 2 - (gender=='male' & seqnames(uniqueBB)=="X" | seqnames(uniqueBB)=="Y")
    
    # Fix cluster and purity discrepancies
    clusters$proportion[which.max(clusters$proportion)] <- purity
    
    cloneFreq <- split(bb$clonal_frequency[subjectHits(overlaps)], queryHits(overlaps))
    cnStates <- matrix(0, nrow=10000, ncol=6)
    colnames(cnStates) <- c("state","m","f","n.m.s","pi.m.s","s")
    
    power.c <- rep(0, nrow(clusters))
    
    deltaFreq <- 0.05 # merge clusters withing deltaFreq
    
    
    for( i in seq_along(uniqueBB)){
        if(!i %in% names(majorCN)) next
        majcni <- majorCN[[as.character(i)]]
        mincni <- minorCN[[as.character(i)]]
        cfi <- cloneFreq[[as.character(i)]]
        effCnTumor <- sum((majcni + mincni)*cfi)
        effCnNormal <- as.numeric(cnNormal[i]) * (1-purity)
        
        if(any(is.na(majcni))) next
        
        mixFlag <- FALSE
        subclonalGainFlag <- FALSE
        clonalFlag <- TRUE
        majdelta <- 0
        mindelta <- 0
        
        majanc <- majder <- majcni
        minanc <- minder <- mincni
        
        if(length(cfi)>1){ # multiple (subclonal) CN states, if so add clonal option (ie. mixture of both states), subclonal states only change by 1..delta(CN)
            d <- colSums(abs(rbind(majcni, mincni) - c(1,1) * (1+ isWgd)))
            derived <- d == max(d) ## derived state further from diploid/tetraploid
            if(all(derived)) next 
            majanc <- majcni[!derived]
            minanc <- mincni[!derived]
            majder <- majcni[derived]
            minder <- mincni[derived]
            majdelta <- majcni[derived] - majcni[!derived]
            mindelta <- mincni[derived] - mincni[!derived]
            majcni <- c(min(majcni), # clonal, sub on allele that doesn't change
                    (majcni[!derived] + cfi[derived]/purity*majdelta), # clonal, sub on allele that does change
                    (majcni[derived] >0) + (majdelta > 0)) # subclonal, subs after or before CNA, m=1,delta
            mincni <- c(min(mincni), (mincni[!derived] + cfi[derived]/purity*mindelta), (mincni[derived] >0) + (mindelta > 0))
            majdelta <- c(0, cfi[derived]/purity*majdelta, majdelta)
            mindelta <- c(0, cfi[derived]/purity*mindelta, mindelta)
            cfi <- c(purity, purity,  cfi[derived])
            mixFlag <- c(FALSE, TRUE, FALSE)
            clonalFlag <- c(TRUE,TRUE,FALSE)
            subclonalGainFlag <- c(FALSE, FALSE, TRUE)
        }
        
        
        a <- sapply(clusters$proportion, function(p) all(abs(p-cfi) > deltaFreq)) # subclone(s) not coinciding with CN change
        if(any(a)){ # assume subclones have derived from most abundant CN state
            majcni <- c(majcni, rep(majcni[which.max(cfi)]>0, sum(a))+0)
            mincni <- c(mincni, rep(mincni[which.max(cfi)]>0, sum(a))+0)
            cfi <- c(cfi, clusters$proportion[a])
            mixFlag <- c(mixFlag, rep(FALSE, sum(a)))
            clonalFlag <- c(clonalFlag, rep(FALSE, sum(a)))
            subclonalGainFlag <- c(subclonalGainFlag, rep(FALSE, sum(a)))
            majdelta <- c(majdelta, rep(0,sum(a)))
            mindelta <- c(mindelta, rep(0,sum(a)))
        }
        totcni <- majcni+mincni
        if(all(totcni==0)) next
        
        k <- 0
        for( j in seq_along(majcni)){
            if(majcni[j]==0 & mincni[j]==0) {
                f <- m <- 0 # allele frequency
                pi.m.s <- n.m.s <- 1
                l <- 1
            }else{
                l <- 1:max(majcni[j], mincni[j]) # mincni>majcni can occur if minor allele changes subclonally
                m <- l
                n.m.s <- rep(1, length(l)) #multiplicity of cn states
                if(!mixFlag[j]){ # single subclone, or no subclonal cn
                    f <- m * cfi[j] / (effCnTumor + effCnNormal)
                    if(mincni[j] > 0)
                        n.m.s[1:min(majcni[j], mincni[j])] <- 2
                    pi.m.s <- n.m.s/sum(n.m.s)
                }else{ # coexisting cn subclones, use mixture
                    d <- if(majdelta[j] != 0) majdelta[j] else mindelta[j] 
                    M <- max(mincni[j]*(mindelta[j]!=0), majcni[j]*(majdelta[j]!=0))
                    m <- (d > 0):M + (M-floor(M))
                    l <- seq_along(m)
                    f <- m *cfi[j] / (effCnTumor + effCnNormal) # Variant on major allele
                    n.m.s <- rep(1, length(l))
                    pi.m.s <- n.m.s/sum(n.m.s)
                }
            }
            cnStates[k + l,"state"]=j
            cnStates[k + l,"m"]=m
            cnStates[k + l,"f"]=f
            cnStates[k + l,"pi.m.s"]=pi.m.s
            cnStates[k + l,"n.m.s"]=n.m.s
            k <- k + length(l)
        }
        whichStates <- (1:k)[cnStates[1:k,"f"]>0]
        
        # State probabilities - based on cell fractions
        cfi.s <- unique(cfi)
        pi.s <- sapply(cfi.s, function(p) ifelse(min(abs(clusters$proportion - p)) < deltaFreq, clusters$n_ssms[which.min(abs(clusters$proportion - p))], 1))
        pi.s <- pi.s/sum(pi.s)
        
        c.to.s <- sapply(cfi.s, function(p) ifelse(min(abs(clusters$proportion - p)) < deltaFreq, which.min(abs(clusters$proportion - p)), NA)) # map to cluster
        s.to.c <- sapply(clusters$proportion, function(c) which.min(abs(cfi.s - c)))
        
        cnStates[1:k,"s"] = as.numeric(factor(cfi, levels=cfi.s))[cnStates[1:k,"state"]]
        
        timing_param <- cbind(cnStates[whichStates,,drop=FALSE], cfi=cfi[cnStates[whichStates,"state"]], pi.s=pi.s[cnStates[whichStates,"s"]], P.m.sX=NA,P.m.sX.lo=NA, P.m.sX.up=NA, T.m.sX=NA, T.m.sX.lo=NA, T.m.sX.up=NA, power.s=NA, power.m.s = NA,
                majCN=majcni[cnStates[whichStates,"state"]], minCN=mincni[cnStates[whichStates,"state"]], 
                majDelta = majdelta[cnStates[whichStates,"state"]], minDelta = mindelta[cnStates[whichStates,"state"]], 
                clonalFlag=clonalFlag[cnStates[whichStates,"state"]], subclonalGainFlag=subclonalGainFlag[cnStates[whichStates,"state"]], mixFlag=mixFlag[cnStates[whichStates,"state"]], majCNanc=majanc, minCNanc=minanc, majCNder=majder, minCNder=minder)
        P[[h[i]]] <- timing_param
        if(H[i] != h[i]) P[[H[[i]]]] <- P[[h[i]]]
        
    }
    return(P)
} 


#' Compute Mutation copy numbers
#' @param vcf A vcf object of ssnms. See VariantAnnotation::readVcf()
#' @param bb The copy number as a GRanges() object, meta data in consensus format. See loadBB()
#' @param clusters A data.frame with the cluster proportion and n_ssms
#' @param purity The purity of the samples
#' @param gender 'male' or 'female'
#' @param isWgd TRUE/FALSE 
#' @param xmin min read support. Needed for power calculations
#' @param rho Dispersion parameter
#' @return A list with elements (D: Annotated Data.Frame, can be added to vcf object; P: Timing parameters to be added to CN Ranges; power.c power of each cluster).
#' 
#' @author mg14
#' @export
computeMutCn <- function(vcf, bb, clusters, purity, gender='female', isWgd= FALSE, xmin=3, rho=0, n.boot=200){
    n <- nrow(vcf)
    D <- DataFrame(MutCN=rep(NA,n), MutDeltaCN=rep(NA,n), MajCN=rep(NA,n), MinCN=rep(NA,n), MajDerCN=rep(NA,n), MinDerCN=rep(NA,n), CNF=rep(NA,n), CNID =as(vector("list", n),"List"), pMutCN=rep(NA,n), pGain=rep(NA,n),pSingle=rep(NA,n),pSub=rep(NA,n), pMutCNTail=rep(NA,n))    
    P <- defineMcnStates(bb,clusters, purity, gender, isWgd)
    if(n==0)
        return(list(D=D, P=P))
    
    altCount <- getAltCount(vcf)
    tumDepth <- getTumorDepth(vcf)
    names(altCount) <- names(tumDepth) <- NULL
    
    # Match VCF and CN
    overlaps <- findOverlaps(vcf, bb)
    D[["CNID"]] <- as(overlaps, "List")
    majorCN <- split(bb$major_cn[subjectHits(overlaps)], queryHits(overlaps))
    m <- bb$minor_cn #hack: minor_cn > 0 in male samples - Battenberg bug?
    if(gender=='male')
        m[as.character(seqnames(bb)) %in% c('X','Y')] <- 0
    minorCN <- split(m[subjectHits(overlaps)], queryHits(overlaps)) 
    h <- selectHits(overlaps, "first")
    H <- selectHits(overlaps, "last")
    
    cnNormal <- 2 - (gender=='male' & seqnames(vcf)=="X" | seqnames(vcf)=="Y")
    
    # Fix cluster and purity discrepancies
    clusters$proportion[which.max(clusters$proportion)] <- purity
    
    cloneFreq <- split(bb$clonal_frequency[subjectHits(overlaps)], queryHits(overlaps))
    
    power.c <- rep(0, nrow(clusters))
    
    deltaFreq <- 0.05 # merge clusters withing deltaFreq
    
    boundaryHits <- countOverlaps(vcf, unique(bb)) > 1 # indels overlapping with CN boundaries
    
    for(globalIt in 1:2){ # 2 iterations, fist local (ie per segment) fit, then global
        for( i in which( (diff(c(-1, h)) !=0 | is.na(diff(c(-1, h)) !=0) ) & ! boundaryHits )){
            if(!i %in% names(majorCN)) next
            if(is.na(h[i])) next
            if(if(i>1) h[i] != h[i-1] | is.na(h[i-1]) else TRUE){ #ie. new segment
                
                hh <- which(h==h[i] & !is.na(altCount) &! is.na(tumDepth))
                if(length(hh)==0) next
                
                if(is.null(bb$timing_param[[h[i]]])){
                    cnStates <- P[[h[i]]]
                    if(is.null(cnStates)) next
                    whichStates <- 1:nrow(cnStates)
                    
                    # State probabilities - based on cell fractions
                    cfi.s <- unique(cnStates[,"cfi"])
                    pi.s <- sapply(cfi.s, function(p) ifelse(min(abs(clusters$proportion - p)) < deltaFreq, clusters$n_ssms[which.min(abs(clusters$proportion - p))], 1))
                    pi.s <- pi.s/sum(pi.s)
                    
                    c.to.s <- sapply(cfi.s, function(p) ifelse(min(abs(clusters$proportion - p)) < deltaFreq, which.min(abs(clusters$proportion - p)), NA)) # map to cluster
                    s.to.c <- sapply(clusters$proportion, function(c) which.min(abs(cfi.s - c)))
                    
                    
                    # Likelihood
                    L <- matrix(sapply(pmin(cnStates[whichStates,"f"],1), function(pp) dtrbetabinom(altCount[hh],tumDepth[hh],pp, rho=rho, xmin=pmin(altCount[hh],0)) + .Machine$double.eps), ncol=length(whichStates))
                    
                    # Power
                    power.sm <- colMeans(matrix(sapply(pmin(cnStates[whichStates,"f"],1), function(pp) 1-ptrbetabinom(pmin(altCount[hh],xmin-1),tumDepth[hh],pp, rho=rho, xmin=0)), ncol=length(whichStates)), na.rm=TRUE)
                    if(globalIt==2){
                        P.m.sX <- P[[h[i]]][,"P.m.sX"]
                        power.s <- sapply(split(power.sm * P.m.sX, cnStates[whichStates,"s"]), sum) # Power for state
                        power.s[!is.na(c.to.s)] <- power.c[na.omit(c.to.s)]
                        power.m.s <- power.sm # Relative power of m states (local) conditioned on s (global).
                        for(s in unique(cnStates[whichStates,"s"])) power.m.s[cnStates[whichStates,"s"]==s] <- power.m.s[cnStates[whichStates,"s"]==s] / max(power.m.s[cnStates[whichStates,"s"]==s]) #power.s[s]
                    }else{ # First iteration
                        power.m.s <- power.sm
                        power.s <- rep(1,length(whichStates))
                    }
                    
                    mm <- function(x) {
                        x <- factor(x)
                        if(nlevels(x) > 1) t(model.matrix( ~ x + 0)) else matrix(1, ncol=length(x))
                    }
                    
                    # EM algorithm (mixture fitting) for pi
                    P.m.sX <- cnStates[whichStates,"pi.m.s"]
                    s.from.m <- mm(cnStates[whichStates,"s"]) # indicator matrix to map
                    for(em.it in 1:100){
                        P.xsm <- L * rep(pi.s[cnStates[whichStates,"s"]] * P.m.sX / power.m.s / power.s[cnStates[whichStates,"s"]], each=nrow(L)) # P(X,s,m)
                        P.sm.x <- P.xsm/rowSums(P.xsm) # P(s,m|Xi)
                        P.sm.X <- pmax(.Machine$double.xmin,colMeans(P.sm.x)) # P(s,m|X) / piState[cnStates[1:k,"state"]] / cnStates[1:k,"pi.m.s"]
                        if(em.it==100) break
                        P.s.X <- s.from.m %*% P.sm.X 
                        P.m.sX <- P.sm.X / P.s.X[cnStates[whichStates,"s"]]
                    }
                    
                    toTime <- function(cnStates, P.m.sX, s.m) {
                        mAnc <- cnStates[,"m"] - cnStates[,"minDelta"] - cnStates[,"majDelta"]
                        mAnc.s <- factor(paste(mAnc, cnStates[,"s"], sep="."))
                        n <- (mAnc <= cnStates[,"majCNanc"]) + (mAnc <= cnStates[,"minCNanc"] )
                        mAnc.s.from.m <- mm(x = mAnc.s)# indicator matrix to map
                        return((mAnc.s.from.m[mAnc.s,] %*% P.m.sX) / (s.m[cnStates[,"s"],] %*% (P.m.sX * mAnc)) *  (cnStates[,"majCNanc"] + cnStates[,"minCNanc"]) / n)
                    }
                    
                    T.m.sX <- toTime(cnStates, P.m.sX, s.from.m) 
                    
                    if(globalIt==1){
                        p <- (sapply(split(power.sm * P.m.sX, cnStates[whichStates,"s"]), sum) * nrow(L))[s.to.c]
                        if(!any(is.na(p) | is.nan(p)))
                            power.c <- power.c + p 
                    }
                    
                    # Bootstrapping for CIs
                    if(globalIt==2){
                        b.m.sX <- if(n.boot>0) sapply(1:n.boot, function(foo){
                                                L <- rbind(L, rep(1e-3, each=ncol(L))) #add an uniformative row
                                                L <- L[sample(1:nrow(L), replace=TRUE),,drop=FALSE]
                                                P.m.sX <- cnStates[whichStates,"pi.m.s"]
                                                for(em.it in 1:50){
                                                    P.xsm <- L * rep(pi.s[cnStates[whichStates,"s"]] * P.m.sX / power.m.s / power.s[cnStates[whichStates,"s"]], each=nrow(L)) # P(X,s,m)
                                                    P.sm.x <- P.xsm/rowSums(P.xsm) # P(s,m|Xi)
                                                    P.sm.X <- colMeans(P.sm.x) # P(s,m|X) / piState[cnStates[1:k,"state"]] / cnStates[1:k,"pi.m.s"]
                                                    P.s.X <- s.from.m %*% P.sm.X 
                                                    P.m.sX <- P.sm.X / P.s.X[cnStates[whichStates,"s"]]
                                                }
                                                return(P.m.sX)
                                            }) else NA
                        if(n.boot>0) try({
                                        CI.m.sX <- apply(b.m.sX, 1, quantile, c(0.025, 0.975))
                                        cnStates[,"P.m.sX.lo"] <- CI.m.sX[1,] 
                                        cnStates[,"P.m.sX.up"] <- CI.m.sX[2,]
                                        B.m.sX <- toTime(cnStates = cnStates, P.m.sX = b.m.sX, s.m = s.from.m)
                                        C.m.sX <- apply(B.m.sX, 1, quantile, c(0.025, 0.975))
                                        cnStates[,"T.m.sX.lo"] <- C.m.sX[1,] 
                                        cnStates[,"T.m.sX.up"] <- C.m.sX[2,]
                                    }, silent=TRUE)
                    }
                    
                    P.sm.x[apply(is.na(P.sm.x)|is.nan(P.sm.x),1,any),] <- NA
                    cnStates[,"P.m.sX"] <- P.m.sX
                    cnStates[,"T.m.sX"] <- T.m.sX
                    cnStates[,"power.s"] <- power.s[cnStates[whichStates,"s"]]
                    cnStates[,"power.m.s"] <- power.m.s
                    
                }else{
                    cnStates <- bb$timing_param[[h[i]]]
                    if(is.null(cnStates)) next
                    P.sm.x <- posteriorMutCN(x=altCount[hh],n=tumDepth[hh], cnStates=cnStates, xmin=0, rho=rho)
                }
                
                # Tail probs
                pMutCNTail <- matrix(sapply(pmin(cnStates[,"f"],1), function(pp) ptrbetabinom(altCount[hh],tumDepth[hh],pp, rho=rho, xmin=pmin(altCount[hh],xmin))), ncol=nrow(cnStates)) #%*% c(pi.s[cnStates[whichStates,"state"]] * P.m.sX)              
                
                P[[h[i]]] <- cnStates
                if(H[i] != h[i]) P[[H[[i]]]] <- P[[h[i]]]
                
                w <- apply(P.sm.x, 1, function(x) if(any(is.na(x))) NA else which.max(x) )
                if(all(is.na(w))) next
                
                D[hh, "pSub"] <- rowSums(P.sm.x[, !cnStates[,"clonalFlag"], drop=FALSE])
                D[hh, "pGain"] <- rowSums(P.sm.x[, cnStates[,"clonalFlag"] & cnStates[,"m"] > 1.00001 + cnStates[,"majDelta"] + cnStates[,"minDelta"], drop=FALSE])
                #D[hh, "pSingle"] <- rowSums(P.sm.x[, cnStates[1:k,"state"] %in% which(clonalFlag) & cnStates[1:k,"m"]<=1, drop=FALSE])
                D[hh, "pSingle"] <-  1 - D[hh, "pSub"] - D[hh, "pGain"]         
                
                D[hh,"MutCN"]  <- cnStates[w,"m"]
                D[hh,"MutDeltaCN"]  <- cnStates[w,"majDelta"] + cnStates[w,"minDelta"]
                D[hh,"MinCN"] <- cnStates[w,"minCNanc"]
                D[hh,"MajCN"] <- cnStates[w,"majCNanc"]
                D[hh,"MinDerCN"] <- cnStates[w,"minCNder"]
                D[hh,"MajDerCN"] <- cnStates[w,"majCNder"]
                
                D[hh,"CNF"]  <- cnStates[w,"cfi"]
                D[hh,"pMutCN"] <- sapply(seq_along(w), function(i) P.sm.x[i,w[i]])
                D[hh,"pMutCNTail"] <- sapply(seq_along(w), function(i) pMutCNTail[i,w[i]])
            }       
        }
        if(globalIt==1){
            power.c <- power.c / sum(!is.na(D[,"pSub"]))
            if(any(is.na(power.c) | power.c==0)) {
                break # Cancel 2nd iteration
                warning("Power calculation yielded NA, aborting.")
            }
            if(any(power.c > 1)) {
                warning("Calculated power > 1, rounding down.")
                power.c <- pmin(1, power.c)
            }
        }
    }
    return(list(D=D,P=P, power.c=power.c))
}

mcnHeader <- function() {
    DataFrame(Number=c(1,1,1,1,1,1,1,1,".",1,1,1,1),Type=c("Float","Float","Integer","Integer","Integer","Integer","Float","Float","Integer","Float","Float","Float","Float"), 
            Description=c("Mutation copy number","Change in MutCN between ancestral and derived state","Major copy number (ancestral)","Minor copy number (ancestral)","Major copy number (derived)","Minor copy number (derived)","Copy number frequency (relative to all cancer cells)", "MutCN probability","BB segment ids","Posterior prob: Early clonal","Posterior prob: Late clonal","Posterior prob: Subclonal", "Tail prob of mixture model"),
            row.names=c("MutCN","MutDeltaCN","MajCN","MinCN","MajDerCN","MinDerCN","CNF","pMutCN","CNID","pGain","pSingle","pSub", "pMutCNTail"))
}

addMutCn <- function(vcf, bb=allBB[[meta(header(vcf))["ID",]]], clusters=allClusters[[meta(header(vcf))["ID",]]]){
    i = info(header(vcf))
    info(header(vcf)) <- rbind(i, mcnHeader())
    info(vcf) <- cbind(info(vcf), computeMutCn(vcf, bb, clusters)$D)
    return(vcf)
}

classifyMutations <- function(x, reclassify=c("missing","all","none")) {
    reclassify <- match.arg(reclassify)
    if(nrow(x) ==0 )
        return(factor(NULL, levels=c("clonal [early]", "clonal [late]", "clonal [NA]", "subclonal")))
    if(class(x)=="CollapsedVCF")
    x <- info(x)
    .clsfy <- function(x) {
        cls <- x$CLS
        if(reclassify %in% c("missing", "none") &! is.null(cls)){
            if(all(unique(cls) %in% c("early", "late", "clonal", "subclonal")))
                cls <- factor(cls, levels=c("early", "late", "clonal", "subclonal"), labels=c("clonal [early]", "clonal [late]", "clonal [NA]", "subclonal"))
            cls <- as.character(cls)
            cls[cls=="NA"] <- NA
            if(reclassify=="missing" & any(is.na(cls)))
                cls[is.na(cls)] <- paste(factor(apply(as.matrix(x[is.na(cls), c("pGain","pSingle","pSub")]), 1, function(x) if(all(is.na(x))) NA else which.max(x)), levels=1:3, labels=c("clonal [early]", "clonal [late]","subclonal"))) ## reclassify missing
        }else{
            cls <- paste(factor(apply(as.matrix(x[, c("pGain","pSingle","pSub")]), 1, function(x) if(all(is.na(x))) NA else which.max(x)), levels=1:3, labels=c("clonal [early]", "clonal [late]","subclonal"))) ## reclassify missing
            
        }
        cls[x$pGain==0 & cls!="subclonal"] <- "clonal [NA]"
        if(!is.null(x$MajCN))
            cls[cls!="subclonal" & (x$MajCN == 1 | x$MinCN == 1) & abs(x$MutCN - x$MutDeltaCN -1) <= 0.0001] <- "clonal [NA]"
        cls <- factor(cls, levels=c("clonal [early]", "clonal [late]", "clonal [NA]", "subclonal"))
    }
    cls <- .clsfy(x)
    return(cls)
}

posteriorMutCN <- function(x,n, cnStates, xmin=3, rho=0.01){
    whichStates <- 1:nrow(cnStates)
    L <- matrix(sapply(pmin(cnStates[whichStates,"f"],1), function(pp) dtrbetabinom(x,n,pp, rho=rho, xmin=pmin(x,xmin)) + .Machine$double.eps), ncol=length(whichStates))
    P.xsm <- L * rep(cnStates[whichStates,"pi.s"] * cnStates[whichStates,"P.m.sX"] / cnStates[whichStates,"power.s"] / cnStates[whichStates,"power.m.s"], each=nrow(L)) # P(X,s,m)
    P.sm.x <- P.xsm/rowSums(P.xsm) # P(s,m|Xi)
    return(P.sm.x)
}


loadBB <- function(file){
    tab <- read.table(file, header=TRUE, sep='\t')
    GRanges(tab$chromosome, IRanges(tab$start, tab$end), strand="*", tab[-3:-1])
}

pGainToTime <- function(vcf){
    P <- matrix(NA, nrow=nrow(vcf), ncol=4, dimnames=list(NULL, c("pEarly","pLate","pClonal[NA]","pSub")))
    P[,c("pEarly","pClonal[NA]","pSub")] <- as.matrix(info(vcf)[,c("pGain","pSingle","pSub")])
    biAllelicGain <- (info(vcf)$MajCN > 1 & (info(vcf)$MinCN > 1 | info(vcf)$MinCN == 0) & ! ((info(vcf)$MajCN == 1 | info(vcf)$MinCN == 1) & abs(info(vcf)$MutCN - info(vcf)$MutDeltaCN -1) <= 0.0001))
    w <- which(biAllelicGain)
    P[w, "pLate"] <- P[w, "pClonal[NA]"]
    P[w, "pClonal[NA]"] <- 0
    P[which(!biAllelicGain),"pLate"] <- 0
    return(P)
}

piToTime <- function(timing_param, type=c("Mono-allelic Gain","CN-LOH", "Bi-allelic Gain (WGD)")){
    type <- match.arg(type)
    evo <- NA
    w <- timing_param[,"s"]==1 &! timing_param[,"mixFlag"] ## Clonal states, not mixture (CN subclonal)
    M <- sum(w) ## Max multiplicity = Major copy number
    m <- sum(w & timing_param[,"n.m.s"]==2) ## Minor CN
    #evo <- paste0("1:1", paste0(2,":",m), if(M>2) paste0(3,":",) else "", collapse="->")
    t <- timing_param[(M:(M-1)),c("T.m.sX","T.m.sX.lo","T.m.sX.up"), drop=FALSE] ## Timing M and M-1
    if(nrow(t)==1) t <- rbind(t, NA)
    if(!any(is.na(t))){
        if(M==4) {
            if(timing_param[M-1,"P.m.sX"] < 0.02){ ## No MCN 3
                if(type=="CN-LOH"){ ## Hotfix for 4+0, treated at 1:1 -> 2:0 -> 4:0
                    t <- timing_param[c(M,M-2),c("T.m.sX","T.m.sX.lo","T.m.sX.up"), drop=FALSE]*c(1,0.5) ## Timing M and M-2
                    evo <- "1:1->2:0->4:0"
                }
                else if(type=="Bi-allelic Gain (WGD)"){         
                    if(m==2) {## Hotfix for 4+2 regions, treated at 1:1 -> 2:1 -> 4:2
                        t <- timing_param[c(M,M-2),c("T.m.sX","T.m.sX.lo","T.m.sX.up"), drop=FALSE] ## Timing M and M-2
                        t[2,] <- pmax(0,2*t[2,] - t[1,])/3
                        evo <- "1:1->2:1->4:2"
                    } else if(m==4) {## Hotfix for 4+4 regions, treated at 1:1 -> 2:2 -> 4:4
                        t <- timing_param[c(M,M-2),c("T.m.sX","T.m.sX.lo","T.m.sX.up"), drop=FALSE]*c(1,0.5) ## Timing M and M-2
                        evo <- "1:1->2:2->4:4"
                    }
                }           
            } else if(type=="Bi-allelic Gain (WGD)"){ ## Can't uniquely time second event
                t[2,] <- NA
            } 
            if(m==3) {
                t[2,] <- NA ## Don'time secondary 4+3 for now, needs more work
            } 
        } else {
            if(M==3 & type=="Bi-allelic Gain (WGD)") {## Hotfix for 3+2 regions, treated at 1:1 -> 2:2 -> 3:2
                t[2,] <- pmax(0,2*t[2,] - t[1,])
                evo <- "1:1->2:2->3:2"
            }
        }
    }
    colnames(t) <- c("","lo","up")
    t[,2] <- pmin(t[,1],t[,2])
    t[,3] <- pmax(t[,1],t[,3])
    t <- pmin(apply(t,2,cumsum),1) ## Times are actually deltas
    if(M < 3) t[2,] <- NA
    t[is.infinite(t)] <- NA
    rownames(t) <- c("",".2nd")
    return(c(t[1,],`.2nd`=t[2,])) ## Linearise
}

bbToTime <- function(bb, timing_param = bb$timing_param, pseudo.count=5){
    sub <- duplicated(bb) 
    covrg <- countQueryHits(findOverlaps(bb, bb)) 
    maj <- sapply(timing_param, function(x) if(length(x) > 0) x[1, "majCNanc"] else NA) #bb$major_cn
    min <- sapply(timing_param, function(x) if(length(x) > 0) x[1, "minCNanc"] else NA) #bb$minor_cn
    type <- sapply(seq_along(bb), function(i){
                if(maj[i] < 2 | is.na(maj[i]) | sub[i] | (maj[i] > 4 & min[i] >= 2)) return(NA)
                type <- if(min[i]==1){ "Mono-allelic Gain" 
                        }else if(min[i]==0){"CN-LOH"}
                        else "Bi-allelic Gain (WGD)"
                return(type)
            })
    time <- t(sapply(seq_along(bb), function(i){
                        if(sub[i] | is.na(type[i])) return(rep(NA,6)) 
                        else piToTime(timing_param[[i]],type[i])
                    }))
    
    res <- data.frame(type=factor(type, levels=c("Mono-allelic Gain","CN-LOH","Bi-allelic Gain (WGD)")), time=time)
    colnames(res) <- c("type","time","time.lo","time.up","time.2nd","time.2nd.lo","time.2nd.up")
    
    # posthoc adjustment of CI's
    res$time.up <- (pseudo.count + bb$n.snv_mnv * res$time.up)/(pseudo.count + bb$n.snv_mnv)
    res$time.lo <- (0 + bb$n.snv_mnv * res$time.lo)/(pseudo.count + bb$n.snv_mnv)
    res$time.2nd.up <- (pseudo.count + bb$n.snv_mnv * res$time.2nd.up)/(pseudo.count + bb$n.snv_mnv)
    res$time.2nd.lo <- (0 + bb$n.snv_mnv * res$time.2nd.lo)/(pseudo.count + bb$n.snv_mnv)
    
    res$time.star <- factor((covrg == 1) + (min < 2 & maj <= 2 | min==2 & maj==2) * (covrg == 1), levels=0:2, labels = c("*","**","***")) ## ***: 2+0, 2+1, 2+2; **: 2<n+1, {3,4}+2; *: subclonal gains
    res$time.star[is.na(res$time)] <- NA
    return(res)
}

simulateMutations <- function(bb, purity=max(bb$clonal_frequency, na.rm=TRUE),  n=40, rho=0.01, xmin=3){
    g <- (averagePloidy(bb)*purity + 2*(1-purity))
    V <- list(VRanges())#VRanges()
    for(i in which(!duplicated(bb)))
        if(bb$n.snv_mnv[i]>1 & !is.null( bb$timing_param[[i]]))try({
                        cnStates <- bb$timing_param[[i]]
                        p <- cnStates[,"pi.s"]* if(!any(is.na(cnStates[,"P.m.sX"]))) cnStates[,"P.m.sX"] else cnStates[,"pi.m.s"]
                        pwr <- cnStates[,"power.m.s"]#(cnStates[,"power.s"] * cnStates[,"power.m.s"])
                        s <- sample(1:nrow(cnStates), size=pmax(1,ceiling(bb$n.snv_mnv[i] * (p %*% (1/pwr)))), prob=p, replace=TRUE)
                        f <- cnStates[s,"f"]
                        mu.c <- (bb$total_cn[i]*purity + 2*(1-purity))/g * n
                        c <- rnbinom(length(f), size=1/rho, mu=mu.c)
                        x <- rbetabinom(n=length(f), size=c, prob=f, rho=rho)
                        pos <- round(runif(length(f), min=start(bb)[i], max=end(bb)[i]))
                        w <- which(x>=xmin)
                        V[[i]] <- VRanges(seqnames=seqnames(bb)[i], IRanges(pos, width=1), ref="N", alt="A", totalDepth=c, altDepth=x)[w]
                    })
    V <- do.call("c", V[!sapply(V, is.null)])
    sampleNames(V) <- "SAMPLE"
    v <- as(V, "VCF")
    info(header(v)) <- rbind(info(header(v)),info(header(finalSnv[[1]]))[c("t_ref_count","t_alt_count"),])
    info(v)$t_alt_count <- altDepth(V)
    info(v)$t_ref_count <- totalDepth(V) - altDepth(V)
    return(v)
}

14.2 PCAWG-functions.R

All basic functions

# This file contains a range of convenience functions for running a 
# range of timing analyses of the PCAWG-11 Evolution and Heterogeneity 
# working group, detailed in PCAWG-final.R
# 
# Author: Moritz Gerstung <moritz.gerstung@ebi.ac.uk>s
###############################################################################

library(Rsamtools)
library(VariantAnnotation)

vcfPath <- '../final/final_consensus_12oct_passonly/snv_mnv'
dpPath <- paste0('../final/consensus_subclonal_reconstruction_20170325')
purityPloidy <- read.table( '../final/consensus.20170218.purity.ploidy.txt', header=TRUE, row.names=1)

allGender <- read.table('../final/2016_12_09_inferred_sex_all_samples.txt', header=TRUE, sep='\t')
allGender <- allGender[!duplicated(allGender$tumourid) & allGender$tumourid != 'tumourid',]
#write.table(gender,'../gender/2016_12_09_inferred_sex_all_samples_CORRECTED_MG.txt', row.names=FALSE, col.names=TRUE, sep='\t', quote=FALSE)
rownames(allGender) <- allGender$tumourid

addTNC <- function(vcf){    
    r = "../ref/genome.fa.gz" #meta(header(v))["reference",]
    if(!"TNC" %in% rownames(header(vcf)@header$INFO)){
        tnc=scanFa(file=r, resize(granges(vcf), 3,fix="center"))
        i = header(vcf)@header$INFO
        info(header(vcf)) <- rbind(i, DataFrame(Number=1,Type="String",Description="Trinucleotide context", row.names="TNC"))
        info(vcf)$TNC <- as.character(tnc)
    }
    return(vcf)
}

dpFiles <- dir(dpPath, pattern="_subclonal_structure.txt", recursive=TRUE)
    
#bbFiles <- dir(bbPath, pattern="_segments.txt", recursive=TRUE)

wccTable <- read.table("../final/wcc_consensus_values_9_12.tsv", header=TRUE, sep='\t')
d <- data.frame(cluster=wccTable$sc_n, n_ssms=wccTable$consensus_mutation_number, proportion = round(wccTable$consensus_cluster_cp,3))
d[d$cluster==1,"proportion"] <- wccTable[d$cluster==1,"purity"]
wccClusters <- split(d, wccTable$sid)
wccPurity <- d[d$cluster==1,"proportion"] 
#plot(wccPurity, purityPloidy[,"purity"])

loadClusters <- function(ID){
    file <- paste0(dpPath,"/",grep(paste0(ID,"[[:punct:]]"), dpFiles, value=TRUE, perl=TRUE))
    if(grepl(".gz", file))
        file <- gzfile(file)
    read.table(file, header=TRUE, sep="\t")
}

loadConsensusClusters <- function(ID){
    file <- paste0(dpPath,"/",grep(paste0(ID,"[[:punct:]]"), dpFiles, value=TRUE, perl=TRUE))
    if(grepl(".gz", file))
        file <- gzfile(file)
    read.table(file, header=TRUE, sep="\t")
}

consensusClustersToOld <- function(clusters){
    data.frame(cluster=clusters$cluster, n_ssms=clusters$n_snvs, proportion=clusters$fraction_total_cells)
}

parseRegion <- function(regions){
    chr <- regmatches(regions, regexpr("^.+(?=:)",regions,perl=TRUE))
    start <- as.numeric(regmatches(regions, regexpr("(?<=:)[0-9]+(?=-)",regions,perl=TRUE)))
    end <- as.numeric(regmatches(regions, regexpr("(?<=-)[0-9]+$",regions,perl=TRUE)))
    data.frame(chr,start,end)
}

loadConsensusCNA <- function(ID, purity=1, path="../final/consensus.20170119.somatic.cna.annotated"){
    file <- grep(paste0(ID,"[[:punct:]]"), dir(path, pattern="cna.annotated.txt", recursive=TRUE, full.names=TRUE), value=TRUE)
    if(grepl(".gz", file))
        file <- gzfile(file)
    tab <- read.table(file, header=TRUE, sep='\t')
    subclonalIndex <- !is.na(tab$total_cn) & !is.na(tab$battenberg_nMaj2_A) & !is.na(tab$battenberg_nMin2_A) & !is.na(tab$battenberg_frac2_A) & (tab$battenberg_nMaj1_A == tab$major_cn & tab$battenberg_nMin1_A == tab$minor_cn | tab$battenberg_nMaj2_A == tab$major_cn & tab$battenberg_nMin2_A == tab$minor_cn)
    ix <- c(1:nrow(tab), which(subclonalIndex))
    gr <- GRanges(tab$chromosome, IRanges(tab$start, tab$end), strand="*", clonal_frequency=purity, tab[-3:-1])[ix]
    if(any(subclonalIndex)){
        gr$clonal_frequency[which(subclonalIndex)] <- tab$battenberg_frac1_A[subclonalIndex] * purity
        gr$major_cn[which(subclonalIndex)] <- tab$battenberg_nMaj1_A[subclonalIndex]
        gr$minor_cn[which(subclonalIndex)] <- tab$battenberg_nMin1_A[subclonalIndex]
        gr$total_cn[which(subclonalIndex)] <- tab$battenberg_nMaj1_A[subclonalIndex] + tab$battenberg_nMin1_A[subclonalIndex]
        gr$clonal_frequency[-(1:nrow(tab))] <- tab$battenberg_frac2_A[subclonalIndex] * purity
        gr$total_cn[-(1:nrow(tab))] <- tab$battenberg_nMaj2_A[subclonalIndex] + tab$battenberg_nMin2_A[subclonalIndex]
        gr$major_cn[-(1:nrow(tab))] <- tab$battenberg_nMaj2_A[subclonalIndex]
        gr$minor_cn[-(1:nrow(tab))] <- tab$battenberg_nMin2_A[subclonalIndex]
    }
    seqlevels(gr) <- c(1:22, "X","Y")
    sort(gr)
}

refFile = "../ref/genome.fa.gz" #meta(header(v))["reference",]
refLengths <- scanFaIndex(file=refFile)
chrOffset <- cumsum(c(0,as.numeric(width(refLengths))))
names(chrOffset) <- c(seqlevels(refLengths), "NA")

averagePloidy <- function(bb) {
    c <- if(!is.null(bb$copy_number)) bb$copy_number else bb$total_cn
    sum(width(bb) * c * bb$clonal_frequency, na.rm=TRUE) / sum(width(bb) * bb$clonal_frequency, na.rm=TRUE)
}

averageEvenPloidy <- function(bb){
    sum(width(bb) * (!bb$major_cn %% 2 & !bb$minor_cn %% 2) * bb$clonal_frequency, na.rm=TRUE) / sum(width(bb) * bb$clonal_frequency, na.rm=TRUE)
}

getTumorCounts <- function(vcf){
    sapply(grep("(F|R).Z", names(geno(vcf)), value=TRUE), function(i) geno(vcf)[[i]][,"TUMOUR"])
}

getTumorDepth <- function(vcf){
    if("t_alt_count" %in% colnames(info(vcf))){ ## consensus data, snv and indel
        info(vcf)$t_alt_count + info(vcf)$t_ref_count
    }else{ ## older data
        if("FAZ" %in% rownames(geno(header(vcf)))){
            rowSums(getTumorCounts(vcf))
        }else{
            geno(vcf)$DEP[,2]
        }
    }
}

getAltCount <- function(vcf){
    if("t_alt_count" %in% colnames(info(vcf))){ ## consensus data, snv and indel
        info(vcf)$t_alt_count
    }else{ ## older formats
        if("FAZ" %in% rownames(geno(header(vcf)))){ ## ie subs
            c <- getTumorCounts(vcf)
            t <- c[,1:4] + c[,5:8]
            colnames(t) <- substring(colnames(t),2,2)
            a <- as.character(unlist(alt(vcf)))
            a[!a%in%c('A','T','C','G')] <- NA
            sapply(seq_along(a), function(i) if(is.na(a[i])) NA else t[i, a[i]])
        }
        else{ ## ie indel
            #(geno(vcf)$PP + geno(vcf)$NP + geno(vcf)$PB + geno(vcf)$NB)[,"TUMOUR"]
            geno(vcf)$MTR[,2]
        }
    }
}



mergeClusters <- function(clusters, deltaFreq=0.05){
    if(nrow(clusters) <= 1) return(clusters)
    h <- hclust(dist(clusters$proportion), members=clusters$n_ssms)
    ct <- cutree(h, h=deltaFreq)
    cp <- as.matrix(cophenetic(h))
    Reduce("rbind",lapply(unique(ct), function(i) {
                        n_ssms <- sum(clusters$n_ssms[ct==i])
                        w <- max(cp[ct==i,ct==i])
                        data.frame(new.cluster=i, n_ssms=n_ssms, proportion=sum(clusters$proportion[ct==i]*clusters$n_ssms[ct==i])/n_ssms, width=w)
                    }
    ))
}


removeSuperclones <- function(clusters, min.frac=0.1, delta.prop=0.1) {
    m <- which(clusters$proportion == max(clusters$proportion[clusters$n_ssms >= 0.1 * sum(clusters$n_ssms)]))
    w <- clusters$proportion >= clusters$proportion[m] - delta.prop
    if(sum(w)>1){
        cl <- as.data.frame(rbind(if(any(!w)) clusters[!w,,drop=FALSE], if(any(w)) colSums(clusters[w,,drop=FALSE]*(clusters[w,"n_ssms"]/sum(clusters[w,"n_ssms"])))))
        cl[nrow(cl),"n_ssms"] <- sum(clusters[w,"n_ssms"])
        clusters <- cl
    }
    return(clusters)
}

clustersFromBB <- function(bb){
    w <- bb$clonal_frequency == max(bb$clonal_frequency, na.rm=TRUE) | bb$clonal_frequency < 0.5 * max(bb$clonal_frequency, na.rm=TRUE)
    t <- table(bb$clonal_frequency[w])
    cl <- data.frame(cluster=seq_along(t), n_ssms=as.numeric(t), proportion=as.numeric(names(t)))
    mergeClusters(cl, deltaFreq=0.2)
}



mergeClustersByMutreadDiff = function(clusters, purity, ploidy, vcf_snv, min_read_diff) {
    calc_exp_mutreads_ccf = function(ccf, purity, ploidy, mean_depth) {
        return(ccf / (purity*ploidy + (1-purity)*2) * mean_depth)
    }
    clusters_new = clusters
    exp_reads = sapply(clusters$ccf, calc_exp_mutreads_ccf, purity=purity, ploidy=ploidy, mean_depth=mean(getTumorDepth(vcf_snv), na.rm=T))
    ccf_diff = exp_reads[1:(length(exp_reads)-1)] - exp_reads[2:length(exp_reads)]
    
    
    if (any(ccf_diff < min_read_diff)) {
        
        # Iteratively merge a pair of clusters untill no more pairs within distance can be found
        merged = T
        while(merged) {
            merged = F
            
            exp_reads = sapply(clusters_new$ccf, calc_exp_mutreads_ccf, purity=purity, ploidy=ploidy, mean_depth=mean(getTumorDepth(vcf_snv), na.rm=T))
            ccf_diff = exp_reads[1:(length(exp_reads)-1)] - exp_reads[2:length(exp_reads)]
            to_merge = which(ccf_diff < min_read_diff)
            
            if (length(to_merge)==0) {
                merged = F
                break
            } else {
                i = to_merge[1]
                clusters_new$ccf[i] = sum(clusters_new$ccf[c(i, i+1)]*clusters_new$n_ssms[c(i, i+1)]) / sum(clusters_new$n_ssms[c(i, i+1)])
                clusters_new$n_ssms[i] = sum(clusters_new$n_ssms[c(i, i+1)])
                clusters_new = clusters_new[-(i+1),]
                merged = T
            }
            
            if (nrow(clusters_new)==1) {
                merged = F
                break
            }
        }
    }
    clusters_new$proportion = clusters_new$ccf * purity
    
    # sorting and renumbering clusters
    clusters_new = clusters_new[with(clusters_new, order(proportion, decreasing=T)),]
    clusters_new$cluster = 1:nrow(clusters_new)
    return(clusters_new)
}





probGenotype <- function(vcf){
    dg <- factor(paste(unlist(info(vcf)$DG)), levels=c("NA",as.character(CANCERGENES)))
    P <- pGainToTime(vcf)
    G <- matrix(0, ncol=5, nrow=nlevels(dg), dimnames=list(levels(dg), c(colnames(P),"NA")))
    t <- table(dg)
    for(g in names(t[t>0]))
        G[g,] <- c(colSums(P[dg==g,,drop=FALSE],na.rm=TRUE), "NA"=sum(is.na(P[dg==g,1])))
    return(G)
}

probGenotypeTail <- function(vcf){
    dg <- factor(paste(unlist(info(vcf)$DG)), levels=c("NA",as.character(CANCERGENES)))
    P <- info(vcf)$pMutCNTail
    G <- rep(NA, nlevels(dg))
    names(G) <- levels(dg)
    t <- table(dg)
    for(g in names(t[t>0]))
        G[g] <- mean(P[dg==g,drop=FALSE],na.rm=TRUE)
    return(G)
}

getGenotype <- function(vcf, reclassify='missing', ...){
    w <- c(TRUE,diff(start(vcf)) != 1)
    cls <- classifyMutations(vcf, reclassify=reclassify)
    t <- info(vcf)$TCN
    if(is.null(t))
        t <- info(vcf)$MinCN + info(vcf)$MajCN
    hom <- factor(info(vcf)$MutCN==t, levels=c(TRUE,FALSE))
    dg <- factor(unlist(info(vcf)$DG), levels=as.character(CANCERGENES))
    table(gene=dg[w], class=cls[w], homozygous=hom[w], ...)
}

tryExceptNull <- function(x) if(class(x)=="try-error") GRanges() else x

loadVcf <- function(ID){
    file <- dir(vcfPath, pattern=paste0(ID, ".+somatic.snv_mnv.TNC.vcf.bgz$"), full.names=TRUE)
    pos <- loadPositions(ID)
    vcf <- readVcf(file, genome="GRCh37") #, param=ScanVcfParam(which=pos))
    f <- findOverlaps(pos, vcf, select="first")
    vcf <- vcf[na.omit(f)]
    vcf <- addDriver(vcf, CANCERGENES)
    i = header(vcf)@header$INFO
    info(header(vcf)) <- rbind(i, DataFrame(Number=1,Type="Numeric",Description="DP cluster", row.names="DPC"))
    i = header(vcf)@header$INFO
    info(header(vcf)) <- rbind(i, DataFrame(Number=1,Type="Numeric",Description="DP cluster probability", row.names="DPP"))
    info(vcf)$DPC <- pos$cluster[!is.na(f)]
    info(vcf)$DPP <- pos$likelihood[!is.na(f)]  
    vcf
}

isDeamination <- function(vcf) grepl("(A.CG)|(T..CG)", paste(as.character(unlist(alt(vcf))),vcf@info$TNC))
isDeaminationNoUV <-  function(vcf) grepl("(A.CG[C,T])|(T.[A,G]CG)", paste(as.character(unlist(alt(vcf))),vcf@info$TNC))


testDriver <- function(vcf) sapply(info(vcf)$VC, function(x) if(length(x) ==0) FALSE  else any(x %in% c('nonsense','missense','ess_splice','frameshift','inframe','cds_distrupted')))

addDriver <- function(vcf, mutsigDrivers){
    i = header(vcf)@header$INFO
    info(header(vcf)) <- rbind(i, DataFrame(Number=1,Type="String",Description="Driver gene", row.names="DG"))
    if(nrow(vcf)==0){
        info(vcf)$DG <- CharacterList()
        return(vcf)
    }
    
    r <- paste(paste0("^",mutsigDrivers,"(?=\\|)"), collapse="|")
    rowIdx <- grepl(r, info(vcf)$VD, perl=TRUE) & testDriver(vcf)
    g <- sapply(info(vcf)$VD, function(x) sub("\\|.+","", x))
    d <- ifelse(rowIdx,g,character(0))
    #d[is.na(d)] <- character(0)
    info(vcf)$DG <- as(d,"CharacterList")
    vcf
}

loadAssignment <- function(ID){
    file <- paste0(dpPath,"/",ID,"_DPoutput_1250iters_250burnin/",ID,"_DP_and_cluster_info.txt")
    read.table(file, header=TRUE, sep="\t")
}

addAssignment <- function(vcf, ID){
    a <- loadAssignment(ID)
    i = header(vcf)@header$INFO
    info(header(vcf)) <- rbind(i, DataFrame(Number=ncol(a),Type="Numeric",Description="DP probability", row.names="DPP"))
    info(vcf)$DPP <- as.matrix(a)
    vcf
}

loadPositions <- function(ID){
    file <- gzfile(paste0(dpPath,"/",ID,"_mutation_assignments.txt.gz"))
    tmp <- read.table(file, header=TRUE, sep="\t")
    #GRanges(tmp$chr, IRanges(tmp$start+1, tmp$end), cluster=tmp$cluster, likelihood=tmp$likelihood)
    GRanges(tmp$chr, IRanges(tmp$pos, width=1), cluster=tmp$cluster)
}

tncToPyrimidine <- function(vcf){
    a <- unlist(alt(vcf))
    r <- ref(vcf)
    tnc <- DNAStringSet(info(vcf)$TNC)
    rc <- grepl("A|G", r)
    tnc[rc] <- reverseComplement(tnc[rc])
    a[rc] <- reverseComplement(a[rc])
    t <- paste0(substr(tnc,1,1), "[",substr(tnc,2,2), ">",a, "]", substr(tnc,3,3))
    n <- c("A","C","G","T")
    f <- paste0(rep(n, each=4), "[", rep(c("C","T"), each=96/2), ">", c(rep(c("A","G","T"), each=48/3), rep(c("A","C","G"), each=48/3)), "]", n)
    factor(t, levels=f)
} 


applyPigeonHole <- function(ID){
    c <- loadClusters(ID)
    p <- purityPloidy[ID,"purity"]
    mcf <- c$proportion#*p
    l <- sapply(1:length(mcf), function(i) mcf[i] > pmax(0,1-mcf))
    w <- which(l & upper.tri(l), arr.ind=TRUE)
    cbind(c$cluster[w[,1]], c$cluster[w[,2]])
}

reduceToCoverRelations <- function(rel){
    if(nrow(rel) ==0) return(rel)
    n <- max(rel)
    P <- matrix(FALSE,n,n)
    for(i in 1:nrow(rel))
        P[rel[i,1],rel[i,2]] <- TRUE
    for(i in 1:n){
        q <- list()
        visit <- logical(n)
        for(j in 1:n)
            if(P[i,j])
                q <- c(q,j)
        while(length(q)>0){
            j <- q[[1]]
            q[[1]] <- NULL
            for(k in 1:n){
                if(P[j,k] & !visit[k]){
                    visit[k] <- TRUE
                    q <- c(q,k)
                    if(P[i,k])
                        P[i,k] <- FALSE
                    if(P[k,i])
                        stop("Error.")
                    
                }
            }
        }
    }
    which(P, arr.ind=TRUE)
}

cnWeights <- function(vcf){
    t <- if(is.null(info(vcf)$TCN)) (info(vcf)$MajCN + info(vcf)$MinCN) else info(vcf)$TCN
    info(vcf)$MutCN / t
}

branchLengths <- function(vcf, type=c("all","deamination")){
    type <- match.arg(type)
    if(type=="deamination")
        w <- isDeamination(vcf)
    else
        w <- rep(TRUE, nrow(vcf))
    cnw <- cnWeights(vcf)
    u <- allClusters[[meta(header(vcf))$META["ID",1]]]$cluster
    b <- sapply(u, function(c) sum(2*cnw * (info(vcf)$DPC==c & w), na.rm=TRUE))
    #if(length(b)==0) b <- rep(0, length(u))
    names(b) <- u
    return(b)
}

avgWeights <- function(vcf, type=c("all","deamination")){
    type <- match.arg(type)
    if(type=="deamination")
        w <- isDeamination(vcf)
    else
        w <- rep(TRUE, nrow(vcf))
    cnw <- cnWeights(vcf)
    mean(2*cnw[w], na.rm=TRUE)
}

predictRealTime <- function(x, signatures=snmf$snmfFit$P[-1,]){
    snmf$snmfFit$P[1,1] / snmf$weight * snmf$nmSolve(x, signatures, maxIter=100)[1,]
}

#' ### Compute graphs (posets)
toGraph <- function(edgelist, branch.length, edge.labels, node.labels=1:max(edgelist)){
    g <- graph.edgelist(edgelist)
    E(g)$weight <- branch.length
    E(g)$name <- edge.labels
    V(g)$name <- node.labels
    return(g)   
}

na.rm <- function(x) x[!is.na(x)]

plotPoset <- function(g){
    c <- colorRampPalette(brewer.pal(9, "Spectral"))(10)
    plot(g, layout=layout.reingold.tilford(g), edge.label=E(g)$name, vertex.size = 25*pmin(1,V(g)$size), edge.width=E(g)$weight/100)
}

#' Distance in poset        
posetDist <- function(g) {
    e <- get.edgelist(g)
    w <-  c(0,E(g)$weight)
    names(w) <- c("Germline", e[,2])
    d <- shortest.paths(g, mode='out')
    d <- d - rep(w[colnames(d)], each=length(w))/2
    diag(d) <- NA
    d
}

getMutationCluster <- function(allMutations, vcf){
    m <- match(allMutations, unlist(info(vcf)$DG))
    info(vcf)$DPC[m]
}

distAsRange <- function(g){
    e <- get.edgelist(g)
    w <-  c(0,E(g)$weight)
    names(w) <- c("Germline", e[,2])
    d <- shortest.paths(g, mode='out')
    y <- shift(IRanges(-w[colnames(d)],0), d["Germline", ])
    names(y) <- paste0(colnames(d), ", genes=",E(g)$name[match(colnames(d), e[,2])])
    y
}


nmSolve <- function(D, P, maxIter = 500, tol=1e-3) {
    n <- nrow(D)
    m <- ncol(D)
    s <- ncol(P)
    tP <- t(P)
    rP <- rep(colSums(P), m)
    D <- as.matrix(D)
    E1 <- E2 <- matrix(runif(s * m, 1e-3, 1), ncol = m)
    err <- 2*tol
    
    iter <- 1
    while (iter < maxIter & err > tol) {
        E1 <- E2
        E2 <- E1 * (tP %*% (D/(P %*% (E1 + .Machine$double.eps))))/rP
        iter <- iter + 1
        err <- mean(abs(E2 - E1)/(E1+.Machine$double.eps), na.rm=TRUE)
        if(iter %% 100 == 0) cat(round(-log10(err)))
    }
    cat("\n")
    if(iter == maxIter) warning(paste("No convergence after",iter, "iterations."))
    E2
}

wnmSolve <- function(D, P, weights =  rep(0, ncol(P)), maxIter = 500, tol=1e-3) {
    D <- as.matrix(D)
    D <- rbind(D, matrix(weights, ncol=ncol(D), nrow=ncol(P)))
    P <- rbind(P, diag(rep(1,ncol(P))))
    n <- nrow(D)
    m <- ncol(D)
    s <- ncol(P)
    tP <- t(P)
    rP <- rep(colSums(P), m)
    E1 <- E2 <- matrix(runif(s * m, 1e-3, 1), ncol = m)
    err <- 2*tol
    
    iter <- 1
    while (iter < maxIter & err > tol) {
        E1 <- E2
        E2 <- E1 * (tP %*% (D/(P %*% (E1 + .Machine$double.eps))))/rP
        iter <- iter + 1
        err <- mean(abs(E2 - E1)/(E1+.Machine$double.eps), na.rm=TRUE)
        if(iter %% 100 == 0) cat(round(-log10(err)))
    }
    cat("\n")
    if(iter == maxIter) warning(paste("No convergence after",iter, "iterations."))
    E2
}



wgdTest <- function(vcf){
    id <- meta(header(vcf))$META["ID",1]
    bb <- allBB[[id]]
    ix <- which(bb$copy_number==4 & bb$minor_cn==2)
    v <- vcf[vcf %over% bb[ix]]
    #w <- sum(as.numeric(width(reduce(bb[ix]))))
    t <- table(info(v)$MutCN, info(v)$TCN, as.character(seqnames(v)), info(v)$DPC)
}

#' Power
power <- function(f,n, theta=6.3, err=1e-4) if(any(is.na(c(f,n,theta,err)))) NA else sum((log10(dbinom(0:n, n, 0:n/n) / dbinom(0:n,n,err)) > theta) * dbinom(0:n,n,f))

testIndel <- function(vcf) sapply(info(vcf)$VC, function(x) if(length(x) ==0) FALSE  else any(x %in% c('frameshift','inframe','ess_splice','SO:0001577:complex_change_in_transcript', 'SO:0001582:initiator_codon_change', 'splice_region')))

asum <- function(x, dim) apply(x, setdiff(seq_along(dim(x)), dim), sum)

#' official driver file
#d <- lapply(2:3, function(sheet) xlsx::read.xlsx2(file="../ref/TableS2_driver_point_mutations_annotation.xlsx", sheetIndex=sheet, colIndex=1:22, stringsAsFactors=FALSE, na.char="NaN"))
#colnames(d[[2]]) <- colnames(d[[1]])
#drivers <- do.call("rbind",d)
#drivers[drivers=="NaN" | drivers==""] <- NA
#drivers <- as.data.frame(sapply(drivers, function(x) if(all(!is.na(as.numeric(x[!is.na(x)])))) as.numeric(x) else x, simplify=FALSE))
finalData <- read.table("../final/ref/release_may2016.v1.4.tsv", header=TRUE, sep="\t")
#r <- gsub("-","",drivers$ref)
#i <- grepl("-",drivers$ref) | grepl("-",drivers$alt)  #drivers$mut_type=="indel" # need to fix indels
#r[i] <- paste0("N",r[i])
#a <- gsub("-","",drivers$alt)
#a[i] <- paste0("N",a[i])
#p <- drivers$pos
#p[i & !grepl("-", drivers$ref)] <- p[i & !grepl("-", drivers$ref)]-1
#m <- sapply(levels(drivers$sample), function(x) grep(x, finalData$sanger_variant_calling_file_name_prefix))
#finalDrivers <- VRanges(seqnames = drivers$chr, ranges=IRanges(p, width =  width(r)), ref=DNAStringSet(r), alt=DNAStringSet(a), sampleNames = finalData$icgc_donor_id[m[drivers$sample]])
#mcols(finalDrivers) <- cbind(sample=drivers$sample, samples=finalData$sanger_variant_calling_file_name_prefix[m[drivers$sample]], ID= drivers$gene_id, drivers[,8:22], mut_type=ifelse(i, "indel","snv"))
#save(finalDrivers, file="../ref/TableS2_driver_point_mutations_annotation.RData")
load(file="../ref/TableS2_driver_point_mutations_annotation.RData")
CANCERGENES <- levels(finalDrivers$ID)

matchDrivers <- function(vcf, finalDrivers) {
    ID <- meta(header(vcf))$META["ID",1]
    d <- finalDrivers[grep(ID, finalDrivers$samples)]
    g <- factor(rep(NA,nrow(vcf)), levels = levels(d$ID))
    if(length(d)==0)
        return(g)
    overlaps <- findOverlaps(vcf, d)
    g[queryHits(overlaps)] <- d$ID[subjectHits(overlaps)]
    return(g)
}

addFinalDriver <- function(vcf, finalDrivers){
    i = header(vcf)@header$INFO
    info(header(vcf)) <- rbind(i, DataFrame(Number=1,Type="String",Description="Driver mutation", row.names="DG"))
    info(vcf)$DG <- factor(rep(NA,nrow(vcf)), levels = levels(finalDrivers$ID))
    if(nrow(vcf)==0)
        return(vcf)
    g <- matchDrivers(vcf = vcf, finalDrivers = finalDrivers)
    info(vcf)$DG <- g
    return(vcf)
}


clinicalData <- read.table("../ref/pcawg_donor_clinical_August2016_v9.tsv", header=TRUE, sep="\t", comment="", quote="")

load("../ref/Sarcs_ages.RDa")
for(x in Sarcs_age)
    clinicalData$donor_age_at_diagnosis[match(as.character(x$icgc_donor_id), as.character(clinicalData$icgc_donor_id))] <- as.numeric(x$Age)
rm(Sarcs_age)
specimenData <- read.table("../ref/pcawg_specimen_histology_August2016_v9.tsv", header=TRUE, sep="\t", comment="", quote="")
specimenData$histology_abbreviation <- sub("CA$","Ca",specimenData$histology_abbreviation)

s <- strsplit(as.character(finalData$sanger_variant_calling_file_name_prefix),",")
sample2donor <- as.character(finalData$icgc_donor_id[unlist(sapply(seq_along(s), function(i) rep(i, length(s[[i]]))))])
names(sample2donor) <- unlist(s)

s <- unlist(strsplit(as.character(finalData$sanger_variant_calling_file_name_prefix),","))
sample2icgc <- unlist(strsplit(as.character(finalData$tumor_wgs_icgc_sample_id),",")) #as.character(finalData$tumor_wgs_icgc_sample_id[unlist(sapply(seq_along(s), function(i) rep(i, length(s[[i]]))))])
names(sample2icgc) <- s#unlist(s)


donor2type <- factor(specimenData$histology_abbreviation, levels=c(sort(unique(specimenData$histology_abbreviation))[-1], ""))
donor2type <- as.character(donor2type)
donor2type[donor2type=="Kidney-RCC" & grepl("clear cell", specimenData$histology_tier4)] <- "Kidney-CCRCC"
donor2type[donor2type=="Kidney-RCC" & grepl("papillary",specimenData$histology_tier4)] <- "Kidney-PapRCC"
donor2type <- factor(donor2type)
names(donor2type) <- specimenData$icgc_donor_id
levels(donor2type)[levels(donor2type)==""] <- "Other/NA"


t <- read.table("../ref/tumour_subtype_consolidation_map.tsv - Unique List of Tumour Types_August.tsv", sep='\t', header=TRUE, comment="")
c <- as.character(t$`Color..RGB.code.`)
names(c) <- sub("CA$","Ca",t$`Abbreviation`)
c <- c[c != ""  & !duplicated(names(c))]
tissueColors <- c(table(donor2type))*NA
tissueColors[names(c)] <- c
tissueColors["Lymph-CLL"] <- "#F4A35D"
tissueColors["Kidney-CCRCC"] <-  tissueColors["Kidney-RCC"]
tissueColors["Kidney-PapRCC"] <- "#E53E00"
tissueColors <- tissueColors[levels(donor2type)]

tissueBorder <- c("white","black")[names(tissueColors) %in% c("Lung-SCC","Lung-AdenoCa")+1]
names(tissueBorder) <- names(tissueColors)

tissueLines <- tissueColors
tissueLines[names(tissueColors) %in% c("Lung-SCC","Lung-AdenoCa")] <- "black"

tissueLty <- c(1,1)[names(tissueColors) %in% c("Lung-SCC","Lung-AdenoCa")+1]
names(tissueLty) <- names(tissueColors)
tissueLty["Lung-SCC"] <- 5
tissueLty["Lung-AdenoCa"] <- 4

tissueCex <- tissueLty
tissueCex[grep("Lung", names(tissueCex))] <- 0.8

averageHom <- function(bb){
    sum(width(bb) * (bb$minor_cn == 0) * bb$clonal_frequency, na.rm=TRUE) / sum(width(bb) * bb$clonal_frequency, na.rm=TRUE)
}

.classWgd <- function(ploidy, hom) 2.9 -2*hom <= ploidy

classWgd <- function(bb) .classWgd(averagePloidy(bb), averageHom(bb))

plotBB <- function(bb, ylim=c(0,max(max(bb$total_cn, na.rm=TRUE))), col=RColorBrewer::brewer.pal(4,"Set2"), type=c("lines","bars"), legend=TRUE, lty.grid=1, col.grid="grey", xaxt=TRUE, xlim=c(min(chrOffset[as.character(seqnames(bb))]+start(bb)),max(chrOffset[as.character(seqnames(bb))]+end(bb))), add=FALSE){
    type <- match.arg(type)
    s <- c(1:22, "X","Y")
    l <- as.numeric(width(refLengths[seqnames(refLengths) %in% s]))
    names(l) <- s
    c <- cumsum(l)
    if(add==FALSE){
        plot(NA,NA, ylab="Copy number",xlab="",xlim=xlim, ylim=ylim, xaxt="n")
        axis(side=1, at=c(0,c), labels=rep('', length(l)+1))
        if(length(regions) == 1)
            if(xaxt) axis(side=1, at=pretty(c(start(regions), end(regions)))+chrOffset[as.character(seqnames(regions))], labels=sitools::f2si(pretty(c(start(regions), end(regions)))), las=1)
        if(xaxt) mtext(side=1, at= cumsum(l) - l/2, text=names(l), line=1)
    }
    if(type=="lines"){
    x0 <- start(bb) + cumsum(l)[as.character(seqnames(bb))] - l[as.character(seqnames(bb))]
    x1 <- end(bb) + cumsum(l)[as.character(seqnames(bb))] - l[as.character(seqnames(bb))]
    lwd <- 5* bb$clonal_frequency / max(bb$clonal_frequency)
    segments(x0=x0, bb$major_cn ,x1, bb$major_cn, col=col[1], lwd=lwd)
    segments(x0=x0, bb$minor_cn -.125,x1, bb$minor_cn-.125, col=col[2], lwd=lwd)
    segments(x0=x0, bb$total_cn+.125,x1, bb$total_cn+.125, col=1, lwd=lwd)
#   cv <- coverage(bb)
#   cv <- cv[s[s%in%names(cv)]]
#   par(xpd=NA)
#   for(n in names(cv)){
#       cc <- cv[[n]]
#       segments(start(cc) + cumsum(l)[n] - l[n] ,-runValue(cc)/2,end(cc)+ cumsum(l)[n] - l[n], -runValue(cc)/2, col=4)
#   }
    }else{
        ub <- unique(bb)
        f <- findOverlaps(ub,bb)
        m <- t(model.matrix( ~ 0 + factor(queryHits(f))))
        ub$total_cn <- m %*% mg14::na.zero(bb$total_cn * bb$clonal_frequency) / max(bb$clonal_frequency)
        ub$major_cn <- m %*% mg14::na.zero(bb$major_cn * bb$clonal_frequency) / max(bb$clonal_frequency)
        ub$minor_cn <- m %*% mg14::na.zero(bb$minor_cn * bb$clonal_frequency) / max(bb$clonal_frequency)
        ub$clonal_frequency <- max(bb$clonal_frequency)
        x0 <- start(ub) + cumsum(l)[as.character(seqnames(ub))] - l[as.character(seqnames(ub))]
        x1 <- end(ub) + cumsum(l)[as.character(seqnames(ub))] - l[as.character(seqnames(ub))]
        rect(x0,0,x1, ub$major_cn, col=col[2], lwd=NA)
        rect(x0,ub$major_cn,x1, ub$total_cn, col=col[1], lwd=NA)
        abline(h = 1:floor(ylim[2]), lty=lty.grid, col=col.grid)
    }
    abline(v = chrOffset[1:25], lty=lty.grid, col=col.grid)
    #if(xaxt) mtext(side=1, line=1, at=chrOffset[1:24] + diff(chrOffset[1:25])/2, text=names(chrOffset[1:24]))
    if(legend){
        if(type=="lines") legend("topleft", c("Total CN","Major CN","Minor CN"), col=c("black", col[1:2]), lty=1, lwd=2, bg='white')
        else legend("topleft", c("Major CN","Minor CN"), fill=col[1:2], bg='white')
    }
}

plotVcf <- function(vcf, bb, clusters, col = RColorBrewer::brewer.pal(9, "Set1")[c(3,4,2,1,9)], ID = meta(header(vcf))[[1]]["ID",1], IS_WGD=classWgd(bb), NO_CLUSTER=FALSE, title=TRUE, legend=TRUE, lty.grid=1, col.grid="grey", xaxt=TRUE, pch=16, pch.out=pch, cex=0.66, xlim=c(0,chrOffset["MT"])) {
    cls <- factor(paste(as.character(info(vcf)$CLS)), levels = c("clonal [early]","clonal [late]","clonal [NA]","subclonal" , "NA"))
    plot(NA,NA, xlab='', ylab="VAF", ylim=c(0,1), xlim=xlim, xaxt="n", cex=cex)
    if(title){
        title(main=paste0(ID,", ", donor2type[sample2donor[ID]], "\nploidy=",round(averagePloidy(bb),2), ", hom=",round(averageHom(bb),2), if(IS_WGD) ", WGD" else "", if(NO_CLUSTER) ", (No clusters available)" else(paste0(", clusters=(",paste(round(clusters$proportion, 2), collapse="; "),")"))), font.main=1, line=1, cex.main=1)
    } 
    abline(v = chrOffset[1:25], lty=lty.grid, col=col.grid)
    if(xaxt) mtext(side=1, line=1, at=chrOffset[1:24] + diff(chrOffset[1:25])/2, text=names(chrOffset[1:24]))
    for(i in which(!sapply(bb$timing_param, is.null))) {
                    s <- start(bb)[i]
                    e <- end(bb)[i]
                    x <- chrOffset[as.character(seqnames(bb)[i])]
                    y <- bb$timing_param[[i]][,"f"]
                    l <- bb$timing_param[[i]][,"pi.s"] * bb$timing_param[[i]][,"P.m.sX"]
                    l[is.na(l)] <- 0
                    if(any(is.na(c(s,e,x,y,l)))) next
                    segments(s+x,y,e+x,y, lwd=l*4+.1)
                    #text(x=(s+e)/2 +x, y=y, paste(signif(bb$timing_param[[i]][,"m"],2),signif(bb$timing_param[[i]][,"cfi"]/purityPloidy[meta(header(vv))["ID",1],"purity"],2), sep=":"), pos=3, cex=0.5)
                }
    points(start(vcf) + chrOffset[as.character(seqnames(vcf))], getAltCount(vcf)/getTumorDepth(vcf),col=col[cls],  pch=ifelse(info(vcf)$pMutCNTail < 0.025 | info(vcf)$pMutCNTail > 0.975, pch.out , pch),  cex=cex)                
    if(legend) legend("topleft", pch=19, col=col, legend=paste(as.numeric(table(cls)), levels(cls)), bg='white')
}

timeToBeta <- function(time){
    mu <- time[,1]
    #if(any(is.na(time))) return(c(NA,NA))
    mu <- pmax(1e-3, pmin(1 - 1e-3, mu))
    v <- (0.5 * (pmax(mu,time[,3])-pmin(mu,time[,2])))^2
    alpha <- mu * (mu * (1-mu) / v - 1)
    beta <- (1-mu) *  (mu * (1-mu) / v - 1)
    return(cbind(alpha, beta))
}

plotTiming <- function(bb, time=mcols(bb), col=paste0(RColorBrewer::brewer.pal(5,"Set2")[c(3:5)],"88"), legend=TRUE, col.grid='grey', lty.grid=1, xlim=c(0,chrOffset["MT"]), plot=2){
    plot(NA,NA, xlab='', ylab="Time [mutations]", ylim=c(0,1), xlim=xlim, xaxt="n")
    if(any(!is.na(bb$time)))
        tryCatch({
                    bb <- bb[!is.na(bb$time)]
                    s <- start(bb)
                    e <- end(bb)
                    x <- chrOffset[as.character(seqnames(bb))]
                    y <- time[,"time"]
                    rect(s+x,time[,"time.lo"],e+x,time[,"time.up"], border=NA, col=col[time[,"type"]], angle = ifelse(bb$time.star=="*" | is.na(bb$time.star),45,135), density=ifelse(bb$time.star == "***", -1, 72))
                    segments(s+x,y,e+x,y)
                    
                    if("time.2nd" %in% colnames(time)){ 
                        w <- !is.na(time[,"time.2nd"])
                        if(sum(w) != 0 & plot==2){
                            s <- start(bb)[w]
                            e <- end(bb)[w]
                            x <- chrOffset[as.character(seqnames(bb))][w]
                            y <- time[w,"time.2nd"]
                            rect(s+x,time[w,"time.2nd.lo"],e+x,time[w,"time.2nd.up"], border=NA, col=sub("88$","44",col)[as.numeric(time[w,"type"])], angle = ifelse(bb$time.star[w]=="*" | is.na(bb$time.star[w]),45,135), density=ifelse(bb$time.star[w] == "***", -1, 72))
                            segments(s+x,y,e+x,y)
                        }
                    }
                }, error=function(x) warning(x))
    abline(v = chrOffset[1:25], lty=lty.grid, col=col.grid)
    s <- c(1:22, "X","Y")
    l <- as.numeric(width(refLengths[seqnames(refLengths) %in% s]))
    names(l) <- s
    c <- cumsum(l)
    axis(side=1, at=c(0,c), labels=rep('', length(l)+1))
    mtext(side=1, line=1, at=chrOffset[1:24] + diff(chrOffset[1:25])/2, text=names(chrOffset[1:24]))
    if(legend) legend("topleft", levels(time[,"type"]), fill=col, bg="white")
}

source("../modules/MutationTime.R/MutationTime.R")

findMainCluster <- function(bb, min.dist=0.05){
    w <- which(bb$n.snv_mnv > 20 & !is.na(bb$time))
#   d <- dist(bb$time[w])
#   ci <- weighted.mean((bb$time.up - bb$time.lo)[w], width(bb)[w])
#   h <- hclust(d, method='average', members=bb$n.snv_mnv[w])
#   c <- cutree(h, h=ci)
#   ww <- c==which.max(table(c))
#   weighted.mean(bb$time[w][ww], 1/((bb$time.up - bb$time.lo + min.dist)[w][ww]), na.rm=TRUE)
    s <- seq(0,1,0.01)
    l2 <- pmin(bb$time.lo, bb$time - min.dist)[w]
    u2 <- pmax(bb$time.up, bb$time + min.dist)[w]
    l1 <- (l2 +  bb$time[w])/2
    u1 <- (u2+  bb$time[w])/2
    wd <- as.numeric(width(bb)[w])
    o <- sapply(s, function(i) sum(wd * ( (l2 <= i & u2 >=i) + (l1 <= i & u1 >= i))))
    s[which.max(o)]
}

fractionGenomeWgdCompatible <- function(bb, min.dist=0.05){
    m <- findMainCluster(bb)
    l <- pmin(bb$time.lo, bb$time - min.dist)
    u <- pmax(bb$time.up, bb$time + min.dist)
    w <- which(l <= m & u >= m)
    avgCi <- weighted.mean(bb$time.up- bb$time.lo, width(bb), na.rm=TRUE)
    sd.wgd <- sqrt(weighted.mean((bb$time[w] - m)^2, width(bb)[w], na.rm=TRUE))
    sd.all <- sqrt(weighted.mean((bb$time - m)^2, width(bb), na.rm=TRUE))
    c(nt.wgd=sum(as.numeric(width(bb))[w]), nt.total=sum(as.numeric(width(bb))[!is.na(bb$time)]), time.wgd=m, n.wgd=length(w), n.all = sum(!is.na(bb$time)), chr.wgd = length(unique(seqnames(bb)[w])), chr.all = length(unique(seqnames(bb)[!is.na(bb$time)])), sd.wgd=sd.wgd, avg.ci=avgCi, sd.all=sd.all) 
}

flattenBB <- function(bb){
    u <- unique(bb)
    d <- duplicated(bb)
    mcols(u) <- mcols(u)[1:7]
    u$total_cn_2 <- u$major_cn_2 <- u$minor_cn_2 <- as.integer(NA)
    u$clonal_frequency_2 <- as.numeric(0)
    if(any(d)){
        s <- bb[d]
        f <- findOverlaps(s, u, select='first')
        mcols(u)[f, c("total_cn_2","major_cn_2","minor_cn_2","clonal_frequency_2")] <- mcols(s)[, c("total_cn","major_cn","minor_cn","clonal_frequency")]
    }
    u
}

reduceBB <- function(bb){
    b <- split(bb, do.call("paste", mcols(bb)[c("clonal_frequency","major_cn","minor_cn")]))
    r <- reduce(b)
    s <- sort(unlist(r))
    d <- DataFrame(t(sapply(strsplit(names(s), " "), as.numeric)))
    names(d) <- c("clonal_frequency","major_cn","minor_cn")#names(mcols(bb))
    mcols(s) <- d
    names(s) <- NULL
    u <- unique(bb)
    f <- findOverlaps(s, u)
    t <- table(subjectHits(f), queryHits(f))
    s$n.snv_mnv <- u$n.snv_mnv %*% as.matrix(t)
    s$total_cn <- s$major_cn + s$minor_cn
    s$timing_param <- vector(mode="list", length=length(s))
    s$timing_param[subjectHits(f)] <- u$timing_param[queryHits(f)]
    return(s)
}

stackTime <- function(bb, time="time", t=seq(0,1,0.01)){
    u <- unique(bb)
    cols <- paste0(time,c("",".up",".lo"))
    w <- as.numeric(width(u))
    u <- mcols(u)
    f <- function(x) pmin(pmax(x,0.01),0.99)
    ut <- f((0.5*5+u[,cols[1]] * u$n.snv_mnv)/(5+u$n.snv_mnv))
    uu <- f(u[,cols[2]])
    ul <- f(u[,cols[3]])
    diff(car::logit(f(t))) * rowSums(sapply(which(!is.na(ut)), function(i) w[i]*dnorm(car::logit(t[-1] - diff(t)/2), mean=car::logit(ut[i]), sd= (car::logit(uu[i]) - car::logit(ul[i]) + 0.05)/4)))#(t <= u$time.up[i] & t >= u$time.lo[i])))
    #rowSums(sapply(which(!is.na(ut)), function(i) w[i]*(t <= u$time.up[i] & t >= u$time.lo[i])))
}

betaFromCi <- function(x, weight.mode=5){
    if(any(is.na(x))) return(rep(NA,2))
    f <- function(par,x) {
        beta <- exp(par)
        sum((qbeta(c(0.025,0.975), beta[1], beta[2])-x[-1])^2)+weight.mode*((beta[1]-1)/(beta[1]+beta[2]-2)-x[1])^2
    }
    tryCatch(exp(optim(c(0.1,0.1), fn=f,x=x)$par), error=c(1,1))
}

histBeta <- function(bb, time="time",n.min=10, s=seq(0.005,0.995,0.01)){
    s <- pmax(0.001,pmin(0.999, s))
    cols <- paste0(time,c("",".lo",".up"))
    w <- which(bb$n.snv_mnv > n.min & !is.na(mcols(bb)[cols[1]]) & !duplicated(bb))
    if(length(w)==0) return(rep(NA, length(s)))
    d <- apply(as.matrix(mcols(bb)[w,c(cols, "n.snv_mnv")]), 1, function(x){
                beta <- betaFromCi(x[1:3])
                beta <- (beta * x[4] + 5*c(1,1))/(x[4]+5) # "posterior" with prior B(1,1)
                dbeta(s,beta[1],beta[2])
            })
    wd <- as.numeric(width(bb)[w])
    o <- d %*% wd
}



plotSample <- function(w, vcf = finalSnv[[w]],  bb = finalBB[[w]], sv=finalSv[[w]], title=w, regions=refLengths[1:24], grid.bb='white',col.bb=c("lightgrey", "darkgrey"), ylim.bb=c(0,5), layout.height=c(4,1.2,3.5), y1=ylim.bb[2]-1) {
    p <- par()
    layout(matrix(1:3, ncol=1), height=layout.height)
    par(mar=c(0.5,3,0.5,0.5), mgp=c(2,0.25,0), bty="L", las=2, tcl=-0.25, cex=1)
    xlim=c(min(chrOffset[as.character(seqnames(regions))]+start(regions)),max(chrOffset[as.character(seqnames(regions))]+end(regions)))
    bbb <- bb[bb %over% regions]
    plotVcf(vcf[vcf %over% regions], bbb, finalClusters[[w]], title=FALSE, legend=FALSE, col.grid='white',  xaxt=FALSE, cex=0.33, xlim=xlim)
    mtext(line=-1, side=3, title, las=1)
    tryCatch({
        par(xpd=NA)
        plotSv(sv, y1=y1, ylim=ylim.bb, regions=regions, add=FALSE, xaxt=FALSE)
        par(xpd=FALSE)
    }, error=function(x) warning(x))
    plotBB(bbb, ylim=ylim.bb, legend=FALSE, type='bar', col.grid=grid.bb, col=col.bb, xaxt=FALSE, xlim=xlim, add=TRUE)
    par(mar=c(3,3,0.5,0.5))
    plotTiming(bbb, xlim=xlim, legend=FALSE, col.grid=NA)
    if(length(regions) == 1)
        axis(side=1, at=pretty(c(start(regions), end(regions)))+chrOffset[as.character(seqnames(regions))], labels=sitools::f2si(pretty(c(start(regions), end(regions)))), las=1)
    if(any(!is.na(bb$time))){
        y0 <- seq(0.005,0.995,0.01)
        s <- histBeta(bb)
        g <- colorRampPalette(RColorBrewer::brewer.pal(4,"Set1")[c(3,2,4)])(100)
        segments(x0=chrOffset["MT"] ,y0=y0,x1=chrOffset["MT"] + s/max(s) * 1e8, col=g, lend=3)
        getMode <- function(s){
            if(all(is.na(s))) return(NA)
            w <- which.max(s)
            if(w %in% c(1, length(s))){
                m <- which(c(0,diff(s))>0 & c(diff(s),0)<0)
                if(length(m)==0) return(w)
                m <- m[which.max(s[m])]
                return(if(s[w] > 2*s[m]) w else m) 
            } else return(w)
        }
        abline(h=y0[getMode(s)], lty=5)
        if("time.2nd" %in% colnames(mcols(bb))) if(any(!is.na(bb$time.2nd))){
        s2 <- histBeta(bb, time="time.2nd")
        segments(x0=chrOffset["MT"] + s/max(s) * 1e8 ,y0=y0,x1=chrOffset["MT"] + s/max(s) * 1e8 + s2/max(s) * 1e8, col=paste0(g,"44"), lend=3)
        abline(h=y0[getMode(s2)], lty=3)
        
    }
    }
    #print(w)
    par(p[setdiff(names(p), c("cin","cra","csi","cxy","din","page"))])
}

plotSv <- function(sv, y0=0,y1=y0, h=1, col=paste0(RColorBrewer::brewer.pal(5,"Set1"),"44"), regions=refLengths[1:24], ylim=c(0,1), xaxt=TRUE,xlim=c(min(chrOffset[as.character(seqnames(regions))]+start(regions)),max(chrOffset[as.character(seqnames(regions))]+end(regions))), add=FALSE){
    if(add==FALSE){
        s <- c(1:22, "X","Y")
        l <- as.numeric(width(refLengths[seqnames(refLengths) %in% s]))
        names(l) <- s
        plot(NA,NA, ylab="Copy number",xlab="",xlim=xlim, ylim=ylim, xaxt="n")
        c <- cumsum(l)
        #axis(side=1, at=c(0,c), labels=rep('', length(l)+1))
        if(length(regions) == 1)
            if(xaxt) axis(side=1, at=pretty(c(start(regions), end(regions)))+chrOffset[as.character(seqnames(regions))], labels=sitools::f2si(pretty(c(start(regions), end(regions)))), las=1)
        if(xaxt) mtext(side=1, at= cumsum(l) - l/2, text=names(l), line=1)
    }
    #r <- rowRanges(sv)
    #a <- unlist(alt(sv))
    vs <- GRanges(info(sv)$MATECHROM, IRanges(info(sv)$MATEPOS, width=1))
    l <- 20
    x0 <- seq(0,1,l=l) 
    y2 <- x0*(1-x0)*4*h
    cls <- factor(as.character(info(sv)$SVCLASS), levels=c("DEL", "DUP", "h2hINV","t2tINV","TRA"))
    w <- which(sv %over% regions | vs %over% regions)
    for(i in w)
        try({
                    x <- seq(start(sv)[i] + chrOffset[as.character(seqnames(sv)[i])], start(vs)[i] + chrOffset[as.character(seqnames(vs)[i])], length.out=l)
                    x <- c(x[1], x, x[length(x)])
                    y <- y1 + y2 * if(grepl("INV", cls[i])) -1 else 1
                    y <- c(y0, y , y0)
                    lines(x, y, col=col[cls[i]])
                    #segments(x0=c(x[1], x[l]), x1=c(x[1],x[l]), y0=y0, y1=y1, col=col[cls[i]])
    })
}

t <- read.table("../ref/release_may2016.v1.1.TiN__donor.TiNsorted.20Jul2016.tsv", header=TRUE, sep="\t")
TiN <- t$TiN_donor
names(TiN) <- t$icgc_donor_id

w <- read.table("../final/structure_weme_released_consensus_merged.txt", header=TRUE)
wemeClustersMerged <- split(w[,1:4], w$sample)

cosineDist <- function(x,y){
    t(x)%*%y/(sqrt(colSums(x^2)  %*% t(colSums(y^2))) )
}

14.3 VCF-annotate.R

# This file contains the commands to time copy number gains using point mutations 
# for a given cancer sample. It runs an earlier version of MutationTimeR and is
# invoked via the shell, passing on arguments about input and output file name.
# 
# Author: Moritz Gerstung <moritz.gerstung@ebi.ac.uk>
###############################################################################

set.seed(42)

args <- commandArgs(trailingOnly = TRUE)

source("PCAWG-functions.R")

vcfFileIn <- args[1]
vcfFileOut <- args[2]

print(vcfFileIn)
print(vcfFileOut)

library(VariantAnnotation)
library(Matrix)

s <- strsplit(vcfFileIn,"/")[[1]]
ID <- sub("\\..+", "", s[length(s)])


print(ID)

#' ## CLUSTERS
# Load clusters
clusters <- consensusClustersToOld(loadConsensusClusters((ID))) # consensus clusters
clusters$proportion <- wccClusters[[ID]]$proportion # WCC adjusted CP
clusters$n_ssms <- wemeClustersMerged[[ID]]$n_ssms # WEME prevalence to fix consensus bug
purity <- purityPloidy[ID,'purity']

#' ## COPYNUMBER
bb <- loadConsensusCNA(ID, purity=purityPloidy[ID, 'purity'])
IS_WGD <- classWgd(bb)

#' ## VCF 
#' Load vcf
vcf <- readVcf(vcfFileIn, genome="GRCh37") #, param=ScanVcfParam(which=pos))

# Add ID & gender
meta(header(vcf))$META <- rbind(meta(header(vcf))$META, DataFrame(Value=c(ID, as.character(allGender[ID, "pred_gender"])), row.names=c("ID", "gender")))

# Add driver genes
vcf <- addFinalDriver(vcf, finalDrivers)

# Add TNC
if(!"TNC" %in% rownames(info(header(vcf)))){
    tnc=scanFa(file=refFile, resize(granges(vcf), 3,fix="center"))
    i = info(header(vcf))
    info(header(vcf)) <- rbind(i, DataFrame(Number=1,Type="String",Description="Trinucleotide context", row.names="TNC"))
    info(vcf)$TNC <- as.character(tnc)
}

#' Add mutation copy numbers
# vcf <-  addMutCn(vcf, bb, clusters)
i = info(header(vcf))
info(header(vcf)) <- rbind(i,mcnHeader())
L <- computeMutCn(vcf, bb, clusters=clusters, purity=purity, xmin=3, gender=as.character(allGender[ID, "pred_gender"]), isWgd=IS_WGD, n.boot=500)
info(vcf) <- cbind(info(vcf), L$D)
bb$timing_param <- L$P 

#' Classify mutations
cls <- classifyMutations(vcf, reclassify='all')
info(vcf)$CLS <- cls
info(header(vcf)) <- rbind(info(header(vcf)), DataFrame(Number="1",Type="String",Description="Mutation classification: {clonal [early/late/NA], subclonal}", row.names="CLS"))

#' Timing
bb$n.snv_mnv <- countOverlaps(bb, vcf)
t <- bbToTime(bb)   
mcols(bb) <- DataFrame(mcols(bb), t)

#' Drivers
info(vcf)$DG <- matchDrivers(vcf, finalDrivers)

#' Save output
writeVcf(vcf, file=vcfFileOut)
bgzip(vcfFileOut, overwrite=TRUE)
unlink(vcfFileOut)
save(vcf, file=paste0(vcfFileOut,".RData"))


#' ## INDEL
vcfIndelFileIn <- sub("20160830","20161006",gsub("snv_mnv","indel", vcfFileIn))
vcfIndelFileOut <-  sub("20160830","20161006",gsub("snv_mnv","indel", vcfFileOut))
#' Load vcf
vcfIndel <- readVcf(vcfIndelFileIn, genome="GRCh37") #, param=ScanVcfParam(which=pos))
#' Add ID & gender
meta(header(vcfIndel))$META <- rbind(meta(header(vcfIndel))$META, DataFrame(Value=c(ID, as.character(allGender[ID, "pred_gender"])), row.names=c("ID", "gender")))
#' Add driver genes
vcfIndel <- addFinalDriver(vcfIndel, finalDrivers)
#' Add mutation copy numbers
i = info(header(vcfIndel))
info(header(vcfIndel)) <- rbind(i,mcnHeader())
L <- computeMutCn(vcfIndel, bb, clusters=clusters, purity=purity, xmin=3, gender=as.character(allGender[ID, "pred_gender"]), isWgd=IS_WGD)
info(vcfIndel) <- cbind(info(vcfIndel), L$D)
#' Classify mutation
clsIndel <- classifyMutations(vcfIndel, reclassify='all')
info(vcfIndel)$CLS <- clsIndel
info(header(vcfIndel)) <- rbind(info(header(vcfIndel)), DataFrame(Number="1",Type="String",Description="Mutation classification: {clonal [early/late/NA], subclonal}", row.names="CLS"))
#'Drivers
info(vcfIndel)$DG <- matchDrivers(vcfIndel, finalDrivers)


#' Save
writeVcf(vcfIndel, file=vcfIndelFileOut)
bgzip(vcfIndelFileOut, overwrite=TRUE)
unlink(vcfIndelFileOut)
save(vcfIndel, file=paste0(vcfIndelFileOut,".RData"))

#' Save BB
bb$n.indel <- countOverlaps(bb, vcfIndel)
seqlevels(bb) <- c(1:22, "X","Y")
bb <- sort(bb)
save(bb, file=sub("snv_mnv","cn",sub(".vcf$",".bb_granges.RData",vcfFileOut)))

#' Save clusters & purity
save(clusters, purity, file=sub("snv_mnv","clusters",sub(".vcf$",".clusters_purity.RData",vcfFileOut)))

#' ## PLOT
pdf(file=sub("snv_mnv","other",sub(".vcf$",".pdf",vcfFileOut)), 12,18)
par(mar=c(1,3,3,1), bty="L", mgp=c(2,.5,0), mfrow=c(4,1),cex=1, las=2)
j <- 1
for(v in c('vcf','vcfIndel')){
    vv <- get(v)
    col <- RColorBrewer::brewer.pal(9, "Set1")[c(3,4,2,1,9)]
    plotVcf(vcf = vv, bb = bb, clusters = clusters, col = col, ID = ID,  IS_WGD = IS_WGD, NO_CLUSTER = FALSE, title=j==1)
    j <- j+1
}
plotBB(bb, ylim=c(0,10))
try(plotTiming(bb))
dev.off()
#plot(start(vcf) + w[as.character(seqnames(vcf))], qnorm(info(vcf)$pMutCNTail), col=col[cls], xlab='Position', ylab="pTail", pch=16)